Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2017 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 7 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Follow-up study of liver metastasis from breast cancer treated by proton beam therapy

  • Authors:
    • Nobuyoshi Fukumitsu
    • Toshiyuki Okumura
    • Haruko Numajiri
    • Daichi Takizawa
    • Kayoko Ohnishi
    • Masashi Mizumoto
    • Teruhito Aihara
    • Hitoshi Ishikawa
    • Koji Tsuboi
    • Hideyuki Sakurai
  • View Affiliations / Copyright

    Affiliations: Proton Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki 305‑8575, Japan
  • Pages: 56-60
    |
    Published online on: June 1, 2017
       https://doi.org/10.3892/mco.2017.1283
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Liver metastasis from breast cancer (LMBC) is an incurable, fatal disease with a very poor prognosis. Although various local treatments have been applied, their clinical utility has not been established. The purpose of this study was to investigate the safety and effectiveness of proton beam therapy (PBT) for the treatment of patients with LMGC. A total of 8 female patients (aged 38‑63 years) with LMBC who received PBT between 2002 and 2012 were retrospectively reviewed. Patients who had tumors confined to the liver were investigated, whereas patients with extrahepatic tumors were excluded. A total of 5 patients had solitary tumors and 3 had multiple tumors. The total irradiation dose was 66‑72.6 Gray equivalent [Gy relative biological effectiveness (RBE)] and 2 patients received concurrent chemotherapy or hormone therapy. The overall and progression‑free survival (OS and PFS) rates, local control (LC) rate and adverse effects were investigated. All the patients completed treatment without interruption and late adverse effects of grade >3 were not observed. The OS rate was 88/73/58%, the PFS rate was 50/25/0% and the LC rate was 86/86/86% at 1/3/5 years, respectively. Thus, PBT is a safe treatment and the OS and PFS rates are comparable to those with other local treatments. PBT may be considered as an effective local treatment option for the treatment of LMBC patients.
View Figures

Figure 1

Figure 2

View References

1 

Hoe AL, Royle GT and Taylor I: Breast liver metastases-incidence, diagnosis and outcome. J R Soc Med. 84:714–716. 1991.PubMed/NCBI

2 

Zinser JW, Hortobagyi GN, Buzdar AU, Smith TL and Fraschini G: Clinical course of breast cancer patients with liver metastases. J Clin Oncol. 5:773–782. 1987. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ and Thun MJ: Cancer statistics, 2005. CA Cancer J Clin. 55:10–30. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Inoue K, Ogawa M, Horikoshi N, Aiba K, Mukaiyama T, Mizunuma N, Itami S, Hirano A, Matsuoka A and Matsumura T: Evaluation of prognostic factors for 233 patients with recurrent advanced breast cancer. Jpn J Clin Oncol. 21:334–339. 1991.PubMed/NCBI

5 

O'Reilly SM, Richards MA and Rubens RD: Liver metastases from breast cancer: The relationship between clinical, biochemical and pathological features and survival. Eur J Cancer. 26:574–577. 1990. View Article : Google Scholar : PubMed/NCBI

6 

Insa A, Lluch A, Prosper F, Marugan I, Martinez-Agullo A and Garcia-Conde J: Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: Analysis of 439 patients. Breast Cancer Res Treat. 56:67–78. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Goldhirsch A, Gelber RD and Castiglione M: Relapse of breast cancer after adjuvant treatment in premenopausal and perimenopausal women: Patterns and prognoses. J Clin Oncol. 6:89–97. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Wyld L, Gutteridge E, Pinder SE, James JJ, Chan SY, Cheung KL, Robertson JF and Evans AJ: Prognostic factors for patients with hepatic metastases from breast cancer. Br J Cancer. 89:284–290. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Folprecht G, Gruenberger T, Bechstein W, Raab HR, Weitz J, Lordick F, Hartmann JT, Stoehlmacher-Williams J, Lang H, Trarbach T, et al: Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann Oncol. 25:1018–1025. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Fukumitsu N, Sugahara S, Nakayama H, Fukuda K, Mizumoto M, Abei M, Shoda J, Thono E, Tsuboi K and Tokuuye K: A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 74:831–836. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ookawa A, et al: Proton beam therapy for hepatocellular carcinoma: A comparison of three treatment protocols. Int J Radiat Oncol Biol Phys. 81:1039–1045. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bush DA, Hillebrand DJ, Slater JM and Slater JD: High-dose proton beam radiotherapy of hepatocellular carcinoma: Preliminary results of a phase II trial. Gastroenterology. 127 5 Suppl 1:S189–S193. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Kawashima M, Furuse J, Nishio T, Konishi M, Ishii H, Kinoshita T, Nagase M, Nihei K and Ogino T: Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol. 23:1839–1846. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Qi WX, Fu S, Zhang Q and Guo XM: Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: A systematic review and meta-analysis. Radiother Oncol. 114:289–295. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kanemoto A, Ishikawa H, Mizumoto M, Okumura T, Hashimoto T, Oshiro Y, Fukumitsu N, Tsuboi K, Sakae T and Sakurai H: Proton beam therapy for liver metastasis from breast cancer: Five case reports and a review of the literature. Int Canc Conf J. 1:pp. 210–214. 2012; View Article : Google Scholar

16 

Fukumitsu N, Hashimoto T, Okumura T, Mizumoto M, Tohno E, Fukuda K, Abei M, Sakae T and Sakurai H: Investigation of the geometric accuracy of proton beam irradiation in the liver. Int J Radiat Oncol Biol Phys. 82:826–833. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS and Suit HD: Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 53:407–421. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

19 

National Cancer Institute, . Common terminology criteria for adverse events (CTCAE). https://ctep.cancer.gov/protocoldevelopment/electronic_applications/ctc.htmMay 28–2009

20 

Adam R, Aloia T, Krissat J, Bralet MP, Paule B, Giacchetti S, Delvart V, Azoulay D, Bismuth H and Castaing D: Is liver resection justified for patients with hepatic metastases from breast cancer? Ann Surg. 244:897–908. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Hoffmann K, Franz C, Hinz U, Schirmacher P, Herfarth C, Eichbaum M, Büchler MW and Schemmer P: Liver resection for multimodal treatment of breast cancer metastases: Identification of prognostic factors. Ann Surg Oncol. 17:1546–1554. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Vlastos G, Smith DL, Singletary SE, Mirza NQ, Tuttle TM, Popat RJ, Curley SA, Ellis LM, Roh MS and Vauthey JN: Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol. 11:869–874. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Abbott DE, Brouquet A, Mittendorf EA, Andreou A, Meric-Bernstam F, Valero V, Green MC, Kuerer HM, Curley SA, Abdalla EK, et al: Resection of liver metastases from breast cancer: Estrogen receptor status and response to chemotherapy before metastasectomy define outcome. Surgery. 151:710–716. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Pocard M, Pouillart P, Asselain B and Salmon R: Hepatic resection in metastatic breast cancer: Results and prognostic factors. Eur J Surg Oncol. 26:155–159. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Duan XF, Dong NN, Zhang T and Li Q: Treatment outcome of patients with liver-only metastases from breast cancer after mastectomy: A retrospective analysis. J Cancer Res Clin Oncol. 137:1363–1370. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Vogl TJ, Naguib NN, Nour-Eldin NE, Eichler K, Zangos S and Gruber-Rouh T: Transarterial chemoembolization (TACE) with mitomycin C and gemcitabine for liver metastases in breast cancer. Eur Radiol. 20:173–180. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Li XP, Meng ZQ, Guo WJ and Li J: Treatment for liver metastases from breast cancer: Results and prognostic factors. World J Gastroenterol. 11:3782–3787. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Caralt M, Bilbao I, Cortés J, Escartín A, Lázaro JL, Dopazo C, Olsina JJ, Balsells J and Charco R: Hepatic resection for liver metastases as part of the ‘oncosurgical’ treatment of metastatic breast cancer. Ann Surg Oncol. 15:2804–2810. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Austin-Seymour MM, Chen GT, Castro JR, Saunders WM, Pitluck S, Woodruff KH and Kessler M: Dose volume histogram analysis of liver radiation tolerance. Int J Radiat Oncol Biol Phys. 12:31–35. 1986. View Article : Google Scholar : PubMed/NCBI

30 

Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ and Wesson M: Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 21:109–122. 1991. View Article : Google Scholar : PubMed/NCBI

31 

Mizumoto M, Tokuuye K, Sugahara S, Nakayama H, Fukumitsu N, Ohara K, Abei M, Shoda J, Tohno E and Minami M: Proton beam therapy for hepatocellular carcinoma adjacent to the porta hepatis. Int J Radiat Oncol Biol Phys. 71:462–467. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ohkawa A, et al: Evaluation of liver function after proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 82:e529–e535. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Hashimoto T, Tokuuye K, Fukumitsu N, Igaki H, Hata M, Kagei K, Sugahara S, Ohara K, Matsuzaki Y and Akine Y: Repeated proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 65:196–202. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Fukumitsu N, Okumura T, Takizawa D, Makishima H, Numajiri H, Murofushi K, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, et al: Proton beam therapy for metastatic liver tumors. Radiother Oncol. 117:322–327. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fukumitsu N, Okumura T, Numajiri H, Takizawa D, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H, Sakurai H, et al: Follow-up study of liver metastasis from breast cancer treated by proton beam therapy. Mol Clin Oncol 7: 56-60, 2017.
APA
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M. ... Sakurai, H. (2017). Follow-up study of liver metastasis from breast cancer treated by proton beam therapy. Molecular and Clinical Oncology, 7, 56-60. https://doi.org/10.3892/mco.2017.1283
MLA
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M., Aihara, T., Ishikawa, H., Tsuboi, K., Sakurai, H."Follow-up study of liver metastasis from breast cancer treated by proton beam therapy". Molecular and Clinical Oncology 7.1 (2017): 56-60.
Chicago
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M., Aihara, T., Ishikawa, H., Tsuboi, K., Sakurai, H."Follow-up study of liver metastasis from breast cancer treated by proton beam therapy". Molecular and Clinical Oncology 7, no. 1 (2017): 56-60. https://doi.org/10.3892/mco.2017.1283
Copy and paste a formatted citation
x
Spandidos Publications style
Fukumitsu N, Okumura T, Numajiri H, Takizawa D, Ohnishi K, Mizumoto M, Aihara T, Ishikawa H, Tsuboi K, Sakurai H, Sakurai H, et al: Follow-up study of liver metastasis from breast cancer treated by proton beam therapy. Mol Clin Oncol 7: 56-60, 2017.
APA
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M. ... Sakurai, H. (2017). Follow-up study of liver metastasis from breast cancer treated by proton beam therapy. Molecular and Clinical Oncology, 7, 56-60. https://doi.org/10.3892/mco.2017.1283
MLA
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M., Aihara, T., Ishikawa, H., Tsuboi, K., Sakurai, H."Follow-up study of liver metastasis from breast cancer treated by proton beam therapy". Molecular and Clinical Oncology 7.1 (2017): 56-60.
Chicago
Fukumitsu, N., Okumura, T., Numajiri, H., Takizawa, D., Ohnishi, K., Mizumoto, M., Aihara, T., Ishikawa, H., Tsuboi, K., Sakurai, H."Follow-up study of liver metastasis from breast cancer treated by proton beam therapy". Molecular and Clinical Oncology 7, no. 1 (2017): 56-60. https://doi.org/10.3892/mco.2017.1283
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team