Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
August-2017 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma

  • Authors:
    • Yakup Bozkaya
    • Nebi̇ Serkan Demi̇rci
    • Ali̇can Kurti̇pek
    • Gökmen   Umut Erdem
    • Nuri̇ye Yildirim Ozdemi̇r
    • Nurullah Zengi̇
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey, Department of Medical Oncology, Ankara Numune Education and Research Hospital, Ankara, Turkey, Department of Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey
  • Pages: 267-274
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/mco.2017.1288
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine whether there are any clinicopathological or prognostic differences between patients with α-fetoprotein-secreting gastric carcinoma (AFP-SGC) and non-AFP-SGC. Pathological parameters, clinical parameters, and treatment efficacy were compared in patients with AFP-SGC and non-AFP-SGC. In total, 362 patients (53 with AFP-SGC and 309 with non-AFP-SGC) were included in the present study. Patients with AFP-SGC had significantly higher levels of lymphovascular invasion, perineural invasion (PNI), rate of liver metastasis, and stage IV cancer compared with patients with non-AFP-SGC (P<0.05). The median overall survival (OS) rate was 12.6 months in the AFP-SGC group, and 22.1 months in the non-AFP-SGC group (P<0.001). The median OS and disease free survival (DFS) of patients with stage I-III AFP-SGC were 28.1 and 13.4 months, respectively, whereas for patients with non-AFP-SGC, the OS and DFS were 45.3 and 38.0 months, respectively (P=0.01; P=0.02). The median OS for the stage IV AFP-SGC and non-AFP-SGC groups was 9.3 and 11.5 months, respectively (P=0.14). Multivariate analysis of the entire patient group revealed that the Eastern Cooperative Oncology Group (ECOG) performance score of ≥2, lymph node involvement, presence of PNI, high levels of carcinoembryonic antigen, and distant metastasis were significantly correlated with OS. The lymph node involvement, ECOG performance score of ≥2, AFP-SGC type, and weight loss at diagnosis were also significant factors influencing the DFS in the stage I-III group. In conclusion, patients with AFP-SGC had more aggressive clinicopathological features and biological behavior with an increased tendency of liver metastasis compared with patients with non-AFP-SGC. In the near future, AFP may become an important surrogate marker to manage therapies of patients with gastric cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bergstrand CG and Czar B: Demonstration of a new protein fraction in serum from the human fetus. Scand J Clin Lab Invest. 8:174–179. 1956. View Article : Google Scholar : PubMed/NCBI

2 

Hamanaka W, Yoneda S, Shirakusa T, Shirahama H, Tashiro Y, Iwasaki A, Shiraishi T and Tsuru H: Alpha-fetoprotein (AFP)-producing adrenocortical carcinoma-long survival with various therapeutic strategies including a lung resection: Report of a case. Surg Today. 38:275–278. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Saito S, Hatano T, Hayakawa M, Koyama Y, Ohsawa A and Iwamasa T: Studies on alpha-fetoprotein produced by renal cell carcinoma. Cancer. 63:544–549. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Bourreille J, Metayer P, Sauger F, Matray F and Fondimare A: [Existence of alpha feto protein during gastric-origin secondary cancer of the liver]. Presse Med. 78:1277–1278. 1970.PubMed/NCBI

5 

Chang YC, Nagasue N, Abe S, Kohno H, Yamanoi A, Uchida M and Nakamura T: The characters of AFP-producing early gastric cancer. Nihon Geka Gakkai Zasshi. 91:1574–1580. 1990.(In Japanese). PubMed/NCBI

6 

Motoyama T, Aizawa K, Watanabe H, Fukase M and Saito K: alpha-Fetoprotein producing gastric carcinomas: A comparative study of three different subtypes. Acta Pathol Jpn. 43:654–661. 1993.PubMed/NCBI

7 

Chang YC, Nagasue N, Abe S, Taniura H, Kumar DD and Nakamura T: Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol. 87:321–325. 1992.PubMed/NCBI

8 

Koide N, Nishio A, Igarashi J, Kajikawa S, Adachi W and Amano J: Alpha-fetoprotein-producing gastric cancer: Histochemical analysis of cell proliferation, apoptosis, and angiogenesis. Am J Gastroenterol. 94:1658–1663. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Greene FL, Page DL and Fleming ID: AJCC cancer staging manual. 6th. Springer; New York: 2002, View Article : Google Scholar

10 

Laurén PA and Nevalainen TJ: Epidemiology of intestinal and diffuse types of gastric carcinoma. A time-trend study in Finland with comparison between studies from high- and low-risk areas. Cancer. 71:2926–2933. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Yamagata T, Yamagata Y, Nakanishi M, Matsunaga K, Minakata Y and Ichinose M: A case of primary lung cancer producing alpha-fetoprotein. Can Respir J. 11:504–506. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Matsueda K, Yamamoto H, Yoshida Y and Notohara K: Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP). J Gastroenterol. 41:1011–1019. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Kinjo T, Taniguchi H, Kushima R, Sekine S, Oda I, Saka M, Gotoda T, Kinjo F, Fujita J and Shimoda T: Histologic and immunohistochemical analyses of α-fetoprotein-producing cancer of the stomach. Am J Surg Pathol. 36:56–65. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Cappetta A, Bergamo F, Mescoli C, Lonardi S, Rugge M and Zagonel V: Hepatoid adenocarcinoma of the colon: What should we target? Pathol Oncol Res. 18:93–96. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Kawamura N, Hatano K, Kakuta Y, Takada T, Hara T and Yamaguchi S: [A case of hepatoid adenocarcinoma of the urinary bladder]. Hinyokika Kiyo. 55:619–622. 2009.PubMed/NCBI

16 

Isonishi S, Ogura A, Kiyokawa T, Suzuki M, Kunito S, Hirama M, Tachibana T, Ochiai K and Tanaka T: Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman. Int J Clin Oncol. 14:70–73. 2009. View Article : Google Scholar : PubMed/NCBI

17 

McIntire KR, Waldmann TA, Moertel CG and Go VL: Serum alpha-fetoprotein in patients with neoplasms of the gastrointestinal tract. Cancer Res. 35:991–996. 1975.PubMed/NCBI

18 

Deng J, You Q, Gao Y, Yu Q, Zhao P, Zheng Y, Fang W, Xu N and Teng L: Prognostic value of perineural invasion in gastric cancer: A systematic review and meta-analysis. PLoS One. 9:e889072014. View Article : Google Scholar : PubMed/NCBI

19 

Dicken BJ, Graham K, Hamilton SM, Andrews S, Lai R, Listgarten J, Jhangri GS, Saunders LD, Damaraju S and Cass C: Lymphovascular invasion is associated with poor survival in gastric cancer: An application of gene-expression and tissue array techniques. Ann Surg. 243:64–73. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Talamonti MS, Kim SP, Yao KA, Wayne JD, Feinglass J, Bennett CL and Rao S: Surgical outcomes of patients with gastric carcinoma: The importance of primary tumor location and microvessel invasion. Surgery. 134:720–727; discussion 727–729. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Liu X, Cheng Y, Sheng W, Lu H, Xu Y, Long Z, Zhu H and Wang Y: Clinicopathologic features and prognostic factors in alpha-fetoprotein-producing gastric cancers: Analysis of 104 cases. J Surg Oncol. 102:249–255. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Matsumoto K and Nakamura T: Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. Biochem Biophys Res Commun. 239:639–644. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Halaban R, Rubin JS, Funasaka Y, Cobb M, Boulton T, Faletto D, Rosen E, Chan A, Yoko K, White W, et al: Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene. 7:2195–2206. 1992.PubMed/NCBI

24 

Tajima H, Matsumoto K and Nakamura T: Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species. Exp Cell Res. 202:423–431. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Matsumoto K and Nakamura T: Hepatocyte growth factor: Molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog. 3:27–54. 1992.PubMed/NCBI

26 

Amemiya H, Kono K, Mori Y, Takahashi A, Ichihara F, Iizuka H, Sekikawa T and Matsumoto Y: High frequency of c-Met expression in gastric cancers producing alpha- fetoprotein. Oncology. 59:145–151. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Zhang JF, Shi SS, Shao YF and Zhang HZ: Clinicopathological and prognostic features of hepatoid adenocarcinoma of the stomach. Chin Med J (Engl). 124:1470–1476. 2011.PubMed/NCBI

28 

Chun H and Kwon SJ: Clinicopathological characteristics of alpha-fetoprotein-producing gastric cancer. J Gastric Cancer. 11:23–30. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Ucar E, Semerci E, Ustun H, Yetim T, Huzmeli C and Gullu M: Prognostic value of preoperative CEA CA 19-9, CA 72-4, and AFP levels in gastric cancer. Adv Ther. 25:1075–1084. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Liu X, Cheng Y, Sheng W, Lu H, Xu X, Xu Y, Long Z, Zhu H and Wang Y: Analysis of clinicopathologic features and prognostic factors in hepatoid adenocarcinoma of the stomach. Am J Surg Pathol. 34:1465–1471. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Hirajima S, Komatsu S, Ichikawa D, Kubota T, Okamoto K, Shiozaki A, Fujiwara H, Konishi H, Ikoma H and Otsuji E: Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer. World J Gastroenterol. 19:6055–6061. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Adachi Y, Tsuchihashi J, Shiraishi N, Yasuda K, Etoh T and Kitano S: AFP-producing gastric carcinoma: Multivariate analysis of prognostic factors in 270 patients. Oncology. 65:95–101. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Chang YC, Nagasue N, Kohno H, Taniura H, Uchida M, Yamanoi A, Kimoto T and Nakamura T: Clinicopathologic features and long-term results of alpha-fetoprotein-producing gastric cancer. Am J Gastroenterol. 85:1480–1485. 1990.PubMed/NCBI

34 

Wang D, Li C, Xu Y, Xing Y, Qu L, Guo Y, Zhang Y, Sun X and Suo J: Clinicopathological characteristics and prognosis of alpha-fetoprotein positive gastric cancer in Chinese patients. Int J Clin Exp Pathol. 8:6345–6355. 2015.PubMed/NCBI

35 

Chen T, Xu XY and Zhou PH: Emerging molecular classifications and therapeutic implications for gastric cancer. Chin J Cancer. 35:492016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bozkaya Y, Demi̇rci NS, Kurti̇pek A, Erdem GU, Ozdemi̇r NY and Zengi̇ N: Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Mol Clin Oncol 7: 267-274, 2017.
APA
Bozkaya, Y., Demi̇rci, N.S., Kurti̇pek, A., Erdem, G.U., Ozdemi̇r, N.Y., & Zengi̇, N. (2017). Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Molecular and Clinical Oncology, 7, 267-274. https://doi.org/10.3892/mco.2017.1288
MLA
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7.2 (2017): 267-274.
Chicago
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7, no. 2 (2017): 267-274. https://doi.org/10.3892/mco.2017.1288
Copy and paste a formatted citation
x
Spandidos Publications style
Bozkaya Y, Demi̇rci NS, Kurti̇pek A, Erdem GU, Ozdemi̇r NY and Zengi̇ N: Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Mol Clin Oncol 7: 267-274, 2017.
APA
Bozkaya, Y., Demi̇rci, N.S., Kurti̇pek, A., Erdem, G.U., Ozdemi̇r, N.Y., & Zengi̇, N. (2017). Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma. Molecular and Clinical Oncology, 7, 267-274. https://doi.org/10.3892/mco.2017.1288
MLA
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7.2 (2017): 267-274.
Chicago
Bozkaya, Y., Demi̇rci, N. S., Kurti̇pek, A., Erdem, G. U., Ozdemi̇r, N. Y., Zengi̇, N."Clinicopathological and prognostic characteristics in patients with AFP-secreting gastric carcinoma". Molecular and Clinical Oncology 7, no. 2 (2017): 267-274. https://doi.org/10.3892/mco.2017.1288
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team