Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-2017 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 7 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®

  • Authors:
    • Hideya Yamazaki
    • Mikio Ogita
    • Kengo Himei
    • Satoaki Nakamura
    • Gen Suzuki
    • Tadayuki Kotsuma
    • Ken Yoshida
    • Yasuo Yoshioka
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan, Radiotherapy Department, Fujimoto Hayasuzu Hospital, Miyakonojo, Miyazaki 885‑0055, Japan, Department of Radiology, Japanese Red Cross Okayama Hospital, Okayama 700‑8607, Japan, Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka 540‑0006, Japan, Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan
    Copyright: © Yamazaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 336-340
    |
    Published online on: July 24, 2017
       https://doi.org/10.3892/mco.2017.1339
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to elucidate the effect of intratumoral abscess/necrosis (AN) on the outcome of patients with recurrent head and neck cancer (HNC) treated by stereotactic radiotherapy. The records of 67 patients treated with CyberKnife® in four institutes between August 2000 and July 2010 were reviewed. The frequency of AN appeared to be increased in younger postoperative patients with large ulcerative tumors. The AN+ group exhibited a better initial response rate compared with the AN‑ group (64 vs. 33%, respectively; P=0.04). The 1‑year local control rate was 51 and 75% in the AN+ and AN‑ groups, respectively (P=0.01), while the respective 1-year overall survival rates were 53 and and 71% (P=0.0004). A total of 21 patients (31%) experienced grade ≥3 toxicities, and carotid blowout syndrome (CBOS) was found in 11 patients, resulting in 8 deaths. A significantly larger proportion of patients in the AN+ group developed CBOS (8/18; 44%) compared with the AN‑ group (3/49; 6%) (P=0.001). Therefore, AN may be an important prognostic factor for patients with recurrent HNC, as well as a predictor of lethal toxicity due to CBOS.
View Figures

Figure 1

Figure 2

View References

1 

Mazeron R, Tao Y, Lusinchi A and Bourhis J: Current concepts of management in radiotherapy for head and neck squamous-cell cancer. Oral Oncol. 45:402–408. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Vokes EE, Weichselbaum RR, Lippman SM and Hong WK: Head and neck cancer. N Eng J Med. 328:184–194. 1993. View Article : Google Scholar

3 

Temam S, Pape E, Janot F, Wibault P, Julieron M, Lusinchi A, Mamelle G, Marandas P, Luboinski B and Bourhis J: Salvage surgery after failure of very accelerated radiotherapy in advanced head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 62:1078–1083. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Wong SJ, Machtay M and Li Y: Locally recurrent, previously irradiated head and neck cancer: Concurrent re-irradiation and chemotherapy, or chemotherapy alone? J Clin Oncol. 24:2653–2658. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Lartigau EF, Tresch E, Thariat J, Graff P, Coche-Dequeant B, Benezery K, Schiappacasse L, Degardin M, Bondiau PY, Peiffert D, et al: Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer. Radiother Oncol. 109:281–285. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kress MA, Sen N, Unger KR, Lominska CE, Deeken JF, Davidson BJ, Newkirk KA, Hwang J and Harter KW: Safety and efficacy of hypofractionated stereotactic body reirradiation in head and neck cancer: Long-term follow-up of a large series. Head Neck. 37:1403–1409. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kodani N, Yamazaki H, Tsubokura T, Shiomi H, Kobayashi K and Nishimura T, Aibe N, Ikeno H and Nishimura T: Stereotactic body radiation therapy for head and neck tumor: Disease control and morbidity outcomes. J Radiat Res. 52:24–31. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cengiz M, Özyiğit G, Yazici G, Doğan A, Yildiz F, Zorlu F, Gürkaynak M, Gullu IH, Hosal S and Akyol F: Salvage reirradiaton with stereotactic body radiotherapy for locally recurrent head-and-neck tumors. Int J Radiat Oncol Biol Phys. 81:104–109. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Yamazaki H, Ogita M, Kodani N, Nakamura S, Inoue H, Himei K, Kotsuma T, Yoshida K, Yoshioka Y, Yamashita K and Udono H: Frequency, outcome and prognostic factors of carotid blowout syndrome after hypofractionated re-irradiation of head and neck cancer using CyberKnife®: A multi-institutional study. Radiother Oncol. 107:305–309. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Yamazaki H, Ogita M, Himei K, Nakamura S, Kotsuma T, Yoshida K and Yoshioka Y: Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife®: A multi-institutional matched-cohort analysis. Radiother Oncol. 115:67–71. 2015. View Article : Google Scholar : PubMed/NCBI

11 

King AD, Tse GM, Ahuja AT, Yuen EH, Vlantis AC, To EW and van Hasselt AC: Necrosis in metastatic neck nodes: Diagnostic accuracy of CT, MR imaging, and US. Radiology. 230:720–726. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Zoumalan RA, Kleinberger AJ, Morris LG, Ranade A, Yee H, DeLacure MD and Myssiorek D: Lymph node central necrosis on computed tomography as predictor of extracapsular spread in metastatic head and neck squamous cell carcinoma: Pilot study. J Laryngol Otol. 124:1284–1288. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ding ZX, Liang BL, Shen J, Xie BK, Huang SQ and Zhang B: Magnetic resonance imaging diagnosis of cervical lymph node metastasis from lingual squamous cell carcinoma. Chin J Cancer. 24:199–203. 2005.(In Chinese).

14 

Goldenberg D, Begum S, Westra WH, Khan Z, Sciubba J, Pai SI, Califano JA, Tufano RP and Koch WM: Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 30:898–903. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Esteller E, León X, de Juan M and Quer M: Delayed carotid blow-out syndrome: A new complication of chemoradiotherapy treatment in pharyngolaryngeal carcinoma. J Laryngol Otol. 126:1189–1191. 2012. View Article : Google Scholar : PubMed/NCBI

16 

McDonald MW, Moore MG and Johnstone PA: Risk of carotid blowout after reirradiation of the head and neck: A systematic review. Int J Radiat Oncol Biol Phys. 82:1083–1089. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Chen KC, Yen TT, Hsieh YL, Chen HC, Jiang RS, Chen WH and Liang KL: Postirradiated carotid blowout syndrome in patients with nasopharyngeal carcinoma: A case-control study. Head Neck. 37:794–799. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamazaki H, Ogita M, Himei K, Nakamura S, Suzuki G, Kotsuma T, Yoshida K and Yoshioka Y: Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Mol Clin Oncol 7: 336-340, 2017.
APA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T. ... Yoshioka, Y. (2017). Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Molecular and Clinical Oncology, 7, 336-340. https://doi.org/10.3892/mco.2017.1339
MLA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7.3 (2017): 336-340.
Chicago
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7, no. 3 (2017): 336-340. https://doi.org/10.3892/mco.2017.1339
Copy and paste a formatted citation
x
Spandidos Publications style
Yamazaki H, Ogita M, Himei K, Nakamura S, Suzuki G, Kotsuma T, Yoshida K and Yoshioka Y: Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Mol Clin Oncol 7: 336-340, 2017.
APA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T. ... Yoshioka, Y. (2017). Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®. Molecular and Clinical Oncology, 7, 336-340. https://doi.org/10.3892/mco.2017.1339
MLA
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7.3 (2017): 336-340.
Chicago
Yamazaki, H., Ogita, M., Himei, K., Nakamura, S., Suzuki, G., Kotsuma, T., Yoshida, K., Yoshioka, Y."Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re‑irradiation using CyberKnife®". Molecular and Clinical Oncology 7, no. 3 (2017): 336-340. https://doi.org/10.3892/mco.2017.1339
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team