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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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September-2017 Volume 7 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Case Report

Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report

  • Authors:
    • Osamu Takakuwa
    • Tetsuya Oguri
    • Takehiro Uemura
    • Kazuki Sone
    • Satoshi Fukuda
    • Minami Okayama
    • Yoshihiro Kanemitsu
    • Hirotsugu Ohkubo
    • Masaya Takemura
    • Yutaka Ito
    • Ken Maeno
    • Akio Niimi
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467‑8601, Japan
  • Pages: 383-385
    |
    Published online on: July 25, 2017
       https://doi.org/10.3892/mco.2017.1349
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Abstract

Osimertinib (AZD9291) is a third‑generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor approved for EGFR‑T790M‑positive non‑small cell lung cancer. A high incidence of interstitial lung disease (ILD) during combination treatment with osimertinib and anti‑programmed cell death‑ligand 1 (PD‑L1) inhibitor has been reported. The current study presents a case of ILD develo­pment during osimertinib treatment following nivolumab (an anti‑PD‑1 antibody) treatment. The 59‑year‑old female was diagnosed with stage IV lung adenocarcinoma harboring a deletion in exon 19 of the EGFR gene. Following nivolumab as a sixth‑line treatment, an EGFR‑T790M‑encoding mutation in EGFR exon 20 was identified by re‑biopsy. Osimertinib was therefore initiated as a seventh‑line treatment. A partial response was subsequently noted; however, 63 days after initia­tion of the treatment the patient presented with dyspnea with decreased oxygenation in the absence of fever and sputum. A computed tomography scan revealed the emergence of ground‑glass opacities with bronchiectasis in both lungs, and a diagnosis of ILD due to osimertinib was made. Following steroid pulse therapy with discontinuation of osimertinib, the patient's chest findings and respiratory condition improved. Therefore, it is considered that anti‑PD‑1 therapies may be associated with a risk of ILD during subsequent osimertinib treatment.
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1 

Jänne PA, Yang JC, Kim DW, Planchard D, Ohe Y, Ramalingam SS, Ahn MJ, Kim SW, Su WC, Horn L, et al: AZD9291 in EGFR inhibitor-resistant non-small cell lung cancer. N Engl J Med. 372:1689–1699. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al: Nivolumab versus docetaxel in advanced squamous-cell non-small cell lung cancer. N Engl J Med. 373:123–135. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 361:947–957. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, et al: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 362:2380–2388. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, et al: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13:239–246. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, et al: Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 31:3327–3334. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yu HA, Arcila ME, Rekhtman N, Sima CS, Zakowski MF, Pao W, Kris MG, Miller VA, Ladanyi M and Riely GJ: Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res. 19:2240–2247. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Hotta K, Kiura K, Takigawa N, Yoshioka H, Harita S, Kuyama S, Yonei T, Fujiwara K, Maeda T, Aoe K, et al: Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer: The Okayama Lung Cancer Study Group experience. J Thorac Oncol. 5:179–184. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Ahn MJ, Yang J, Yu H, Saka H, Ramalingam S, Goto K, Kim SW, Yang L, Walding A and Oxnard GR: 136O: Osimertinib combined with durvalumab in EGFR-mutant non-small cell lung cancer: Results from the TATTON phase Ib trial. J Thorac Oncol. 11:S1152016. View Article : Google Scholar : PubMed/NCBI

10 

Gibbons DL, Chow LQ, Kim DW, Kim SW, Yeh T, Song X, Jiang H, Taylor R, Karakunnel J and Creelan B: 570 Efficacy, safety and tolerability of MEDI4736 (durvalumab [D]), a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib (G): A phase I expansion in TKI-naïve patients (pts) with EGFR mutant NSCLC. J Thorac Oncol. 11:S792016. View Article : Google Scholar : PubMed/NCBI

11 

Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, Powderly JD, Heist RS, Carvajal RD, Jackman DM, et al: Overall survival and long-term safety of nivolumab (anti-programmed death 1 Antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 33:2004–2012. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Lee CK, Man J, Lord S, Links M, Gebski V, Mok T and Yang JC: Checkpoint inhibitors in metastatic EGFR-mutated non-small cell lung cancer-A meta-analysis. J Thorac Oncol. 12:403–407. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zhang T, Xie J, Arai S, Wang L, Shi X, Shi N, Ma F, Chen S, Huang L, Yang L, et al: The efficacy and safety of anti-PD-1/PD-L1 antibodies for treatment of advanced or refractory cancers: A meta-analysis. Oncotarget. 7:73068–73079. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Takakuwa O, Oguri T, Uemura T, Sone K, Fukuda S, Okayama M, Kanemitsu Y, Ohkubo H, Takemura M, Ito Y, Ito Y, et al: Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report. Mol Clin Oncol 7: 383-385, 2017.
APA
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M. ... Niimi, A. (2017). Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report. Molecular and Clinical Oncology, 7, 383-385. https://doi.org/10.3892/mco.2017.1349
MLA
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M., Kanemitsu, Y., Ohkubo, H., Takemura, M., Ito, Y., Maeno, K., Niimi, A."Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report". Molecular and Clinical Oncology 7.3 (2017): 383-385.
Chicago
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M., Kanemitsu, Y., Ohkubo, H., Takemura, M., Ito, Y., Maeno, K., Niimi, A."Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report". Molecular and Clinical Oncology 7, no. 3 (2017): 383-385. https://doi.org/10.3892/mco.2017.1349
Copy and paste a formatted citation
x
Spandidos Publications style
Takakuwa O, Oguri T, Uemura T, Sone K, Fukuda S, Okayama M, Kanemitsu Y, Ohkubo H, Takemura M, Ito Y, Ito Y, et al: Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report. Mol Clin Oncol 7: 383-385, 2017.
APA
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M. ... Niimi, A. (2017). Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report. Molecular and Clinical Oncology, 7, 383-385. https://doi.org/10.3892/mco.2017.1349
MLA
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M., Kanemitsu, Y., Ohkubo, H., Takemura, M., Ito, Y., Maeno, K., Niimi, A."Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report". Molecular and Clinical Oncology 7.3 (2017): 383-385.
Chicago
Takakuwa, O., Oguri, T., Uemura, T., Sone, K., Fukuda, S., Okayama, M., Kanemitsu, Y., Ohkubo, H., Takemura, M., Ito, Y., Maeno, K., Niimi, A."Osimertinib‑induced interstitial lung disease in a patient with non‑small cell lung cancer pretreated with nivolumab: A case report". Molecular and Clinical Oncology 7, no. 3 (2017): 383-385. https://doi.org/10.3892/mco.2017.1349
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