Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Surgery is the preferred treatment for bile duct hamartomas

  • Authors:
    • Xiao‑Yu Yang
    • Hai‑Bo Zhang
    • Bin Wu
    • Ai‑Jun Li
    • Xiao‑Hui Fu
  • View Affiliations / Copyright

    Affiliations: Division of Special Treatment II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China, The First Department of General Surgery, Cixian People's Hospital, Handan, Hebei 056500, P.R. China
  • Pages: 649-653
    |
    Published online on: July 31, 2017
       https://doi.org/10.3892/mco.2017.1354
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bile duct hamartoma (BDH) is a rare liver disease with a rising incidence in recent years. A retrospective study on BDH patients between June 2007 and December 2015 was conducted. All the medical records, including clinical, imaging and pathological characteristics, were retrieved. Follow‑up data were obtained by telephone communication. The majority of the patients had no symptoms and the laboratory tests were normal. The appearance on ultrasound examination was variable. The lesion exhibited low density on plain computed tomography and no enhancement in 4 cases, and inhomogeneous enhancement in 1 case. Magnetic resonance imaging examination revealed hypointensity on T1-weighted imaging (WI), hyperintensity on T2WI, no enhancement in 1 case, and enhancement in 4 cases. Two patients underwent magnetic resonance cholangiopancreatography due to jaundice and intrahepatic bile duct dilation. The preoperative diagnosis was liver cancer in 4 cases, hepatic hilar biliary obstruction in 1, chronic calculous cholecystitis in 1, suspected hepatic abscess in 1, and benign liver tumor in 2 cases. All the patients underwent surgery. Nest‑like cell arrangements were observed in 2 patients, and in 1 patient the lesion transformed to intrahepatic cholangiocarcinoma, resulting in the patient's death 25 months after surgery. Thus, BDH may transform into a life‑threatening cholangiocarcinoma and it should be surgically removed. Furthermore, the mechanism underlying carcinogenesis in BDH requires further investigation.
View Figures

Figure 1

View References

1 

von Meyenburg H: Uber die Cystenleber. Beitr Pathol Anat. 64:477–532. 1918.(In German).

2 

Singh Y, Cawich SO, Ramjit C and Naraynsingh V: Rare liver tumor: Symptomatic giant von Meyenburg complex. J Surg Case Rep. 2016:pii: rjw1952017. View Article : Google Scholar

3 

Kim HK and Jin SY: Cholangiocarcinoma arising in von Meyenburg complexes. Korean J Hepatol. 17:161–164. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Parekh V and Peker D: Malignant transformation in von-meyenburg complexes: Histologic and immunohistochemical clues with illustrative cases. Appl Immunohistochem Molecul Morphol: AIMM. 23:607–614. 2015. View Article : Google Scholar

5 

Gupta A, Pattnaik B, Das A and Kaman L: Von Meyenburg complex and complete ductal plate malformation along with Klatskin tumour: A rare association. BMJ Case Reports. 2016:10.1136/bcr-2016-215220, 2016.

6 

Chandramouleeswari K, Anita S and Shivali B: Mesenchymal hamartoma of the liver: A case report. J Clin Diagn Res. 6:1552–1554. 2012.PubMed/NCBI

7 

Hashimoto M, Ouchi M, Norose J, Suda FS, Suzuki K, Matsumura N, Lgari Y, Suzuki T, Nakano H, Mizuse M, et al: Bile duct hamartomas (von Meyenburg complexes) associated with a bacterial infection: Case report of elderly diabetic patient. Geriatr Geront Int. 11:534–536. 2011. View Article : Google Scholar

8 

Sinakos E, Papalavrentios L, Chourmouzi D, Dimopoulou D, Drevelegas A and Akriviadis E: The clinical presentation of Von Meyenburg complexes. Hippokratia. 15:170–173. 2011.PubMed/NCBI

9 

Cnossen WR and Drenth JP: Polycystic liver disease: An overview of pathogenesis, clinical manifestations and management. Orphanet J Rare Dis. 9:692014. View Article : Google Scholar : PubMed/NCBI

10 

Xu AM, Xian ZH, Zhang SH and Chen XF: Intrahepatic cholangiocarcinoma arising in multiple bile duct hamartomas: Report of two cases and review of the literature. Eur J Gastroenterol Hepatol. 21:580–584. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Lung PF, Jaffer OS, Akbar N, Sidhu PS and Ryan SM: Appearances of von meyenburg complex on cross sectional imaging. J Clin Imaging Sci. 3:222013. View Article : Google Scholar : PubMed/NCBI

12 

Shin YM: Biliary hamartoma presented as a single mass. Korean J Hepatol. 17:331–334. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Shi QS, Xing LX, Jin LF, Wang H, Lv XH and Du LF: Imaging findings of bile duct hamartomas: A case report and literature review. Int J Clin Exp Med. 8:13145–13153. 2015.PubMed/NCBI

14 

Wohlgemuth WA, Böttger J and Bohndorf K: MRI, CT, US and ERCP in the evaluation of bile duct hamartomas (von Meyenburg complex): A case report. Eur Radiol. 8:1623–1626. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Luo TY, Itai Y, Eguchi N, Kurosaki Y, Onaya H, Ahmadi Y, Niitsu M and Tsunoda HS: Von Meyenburg complexes of the liver: imaging findings. J Comput Assist Tomogr. 22:372–378. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Zheng RQ, Zhang B, Kudo M, Onda H and Inoue T: Imaging findings of biliary hamartomas. World J Gastroenterol. 11:6354–6359. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Suzuki H, Tsurita G, Ishihara S, Akahane M, Kitayama J and Nagawa H: Resovist-enhanced MRI for preoperative assessment of colorectal hepatic metastases: A case of multiple bile duct hamartomas associated with colon cancer. Case Rep Gastroenterol. 2:509–516. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Patel S, Rajalakshmi BR and Manjunath GV: Histopathologic findings in autopsies with emphasis on interesting and incidental findings-a pathologist's perspective. J Clin Diagn Res. 10:EC08–EC12. 2016.PubMed/NCBI

19 

Gong J, Kang W and Xu J: MR imaging and MR Cholangiopancreatography of multiple biliary hamartomas. Quant Imaging Med Surg. 2:133–134. 2012.PubMed/NCBI

20 

Lin S, Weng Z, Xu J, Wang MF, Zhu YY and Jiang JJ: A study of multiple biliary hamartomas based on 1697 liver biopsies. Eur J Gastroenterol Hepatol. 25:948–952. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Saidi RF, Yoon V, Jabbour N, Shah SA and Bozorgzadeh A: Liver transplantation from a donor with multiple biliary hamartomata. Int J Organ Transplant Med. 4:35–37. 2013.PubMed/NCBI

22 

Barboi OB, Moisii LG, Albu-Soda A, Ciortescu I and Drug V: Biliary hamartoma. Clujul Med. 86:383–384. 2013.PubMed/NCBI

23 

Yamada N, Sanada Y, Katano T, Tashiro M, Hirata Y, Okada N, Ihara Y, Miki A, Sasanuma H, Urahashi T, et al: Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report. World J Gastroenterol. 22:9865–9870. 2016. View Article : Google Scholar : PubMed/NCBI

24 

van Vlerken LG, van Leeuwen MS, Schipper ME and van Erpecum KJ: The ‘Von Meyenburg complex’: An unusual cause of cholangitis? Clin Res Hepatol Gastroenterol. 35:762–764. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Ioannidis O, Iordanidis F, Paraskevas G, Ntoumpara M, Tsigkriki L, Chatzopoulos S, Kotronis A, Papadimitriou N, Konstantara A, Makrantonakis A, et al: Incidentally discovered white subcupsular liver nodules during laparoscopic surgery: Biliary hamartoma and peribiliary gland hamartoma. Klin Onkol. 25:468–470. 2012.PubMed/NCBI

26 

Patel SR, Misra V, Verma K, Gupta P and Dhingra V: Benign hepatic mesenchymal hamartoma (HMH) - A case report. J Clin Diagn Res. 8:119–120. 2014.PubMed/NCBI

27 

Ettel M, Eze O and Xu R: Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma. World J Hepatol. 7:2563–2570. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Liu S, Zhao B, Ma J, Li J and Li X: Lesions of biliary hamartoms can be diagnosed by ultrasonography, computed tomography and magnetic resonance imaging. Int J Clin Exp Med. 7:3370–3377. 2014.PubMed/NCBI

29 

Lee KB: Histopathology of a benign bile duct lesion in the liver: Morphologic mimicker or precursor of intrahepatic cholangiocarcinoma. Clin Mol Hepatol. 22:400–405. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang XY, Zhang HB, Wu B, Li AJ and Fu XH: Surgery is the preferred treatment for bile duct hamartomas. Mol Clin Oncol 7: 649-653, 2017.
APA
Yang, X., Zhang, H., Wu, B., Li, A., & Fu, X. (2017). Surgery is the preferred treatment for bile duct hamartomas. Molecular and Clinical Oncology, 7, 649-653. https://doi.org/10.3892/mco.2017.1354
MLA
Yang, X., Zhang, H., Wu, B., Li, A., Fu, X."Surgery is the preferred treatment for bile duct hamartomas". Molecular and Clinical Oncology 7.4 (2017): 649-653.
Chicago
Yang, X., Zhang, H., Wu, B., Li, A., Fu, X."Surgery is the preferred treatment for bile duct hamartomas". Molecular and Clinical Oncology 7, no. 4 (2017): 649-653. https://doi.org/10.3892/mco.2017.1354
Copy and paste a formatted citation
x
Spandidos Publications style
Yang XY, Zhang HB, Wu B, Li AJ and Fu XH: Surgery is the preferred treatment for bile duct hamartomas. Mol Clin Oncol 7: 649-653, 2017.
APA
Yang, X., Zhang, H., Wu, B., Li, A., & Fu, X. (2017). Surgery is the preferred treatment for bile duct hamartomas. Molecular and Clinical Oncology, 7, 649-653. https://doi.org/10.3892/mco.2017.1354
MLA
Yang, X., Zhang, H., Wu, B., Li, A., Fu, X."Surgery is the preferred treatment for bile duct hamartomas". Molecular and Clinical Oncology 7.4 (2017): 649-653.
Chicago
Yang, X., Zhang, H., Wu, B., Li, A., Fu, X."Surgery is the preferred treatment for bile duct hamartomas". Molecular and Clinical Oncology 7, no. 4 (2017): 649-653. https://doi.org/10.3892/mco.2017.1354
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team