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Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases

  • Authors:
    • Marco Massani
    • Giovanni Capovilla
    • Cesare Ruffolo
    • Roberta Bonariol
    • Paola Maccatrozzo
    • Francesco Tuci
    • Giuseppe Battistella
    • Gian Luca Grazi
    • Nicolò Bassi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Regional Center for HPB Surgery, Regional Hospital of Treviso, I-31100 Treviso, Italy, Department of Surgical, Oncological and Gastroenterological Sciences, Padova University Hospital, University of Padova, I-35128 Padova, Italy, Department of Statistics and Epidemiology, Azienda ULSS 9, I-31100 Treviso, Italy, Department of Surgery, Regina Elena National Cancer Institute, I-00144 Rome, Italy
    Copyright: © Massani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 529-538
    |
    Published online on: August 1, 2017
       https://doi.org/10.3892/mco.2017.1358
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Abstract

The aim of the present study was to evaluate the risk factors for postoperative complications following liver resection for colorectal cancer liver metastases. Patients who underwent hepatic resection for colorectal cancer liver metastases were stratified according to chemotherapy administration and body mass index (BMI) to eliminate potential confounding factors. A univariate analysis was conducted to identify potential risk factors for postoperative complications following liver resection. Variables that exhibited a potential association were evaluated by multivariable logistic regression analysis to identify those independently associated with postoperative morbidity. Between January 2012 and March 2012, 100 patients underwent hepatic resection for liver metastases from colorectal carcinoma at the Treviso Regional Hospital (Treviso, Italy) and at the Regina Elena National Cancer Institute (Rome, Italy). Of the 100 patients, 61 received preoperative oxaliplatin‑ or irinotecan‑based chemotherapy. A total of 25 the patients had a BMI of ≥28 kg/m2. On univariate analysis, BMI ≥28 kg/m2 was found to be positively correlated with the presence of steatosis (P<0.01) and steatohepatitis (P<0.01). The administration of preoperative chemotherapy was correlated with the development of steatosis (P<0.01), steatohepatitis (P=0.02) and postoperative complications (P=0.03). Even following stratification for the use of preoperative chemotherapy, BMI ≥28 kg/m2 maintained its positive association with steatohepatitis. On multivariate analysis, steatohepatitis (P=0.005, HR=0.118, 95% CI: 0.027‑0.518) and blood transfusions (P=0.001, HR=0.131, 95% CI: 0.038‑0.452) were independently associated with postoperative complications. BMI ≥28 kg/m2 (P=0.004, HR=8.30, 95% CI: 2.39‑28.7) and irinotecan treatment (P=0.016, HR=0.16, 95% CI: 0.037‑0.711) were independent risk factors for steatohepatitis. In conclusion, steatohepatitis and perioperative blood transfusions were found to be the main determinant of postoperative complications following liver resection for colorectal liver metastases. Overweight patients may be more prone to the cytotoxic effects of irinotecan, harboring a higher risk of developing steatohepatitis.
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Copy and paste a formatted citation
Spandidos Publications style
Massani M, Capovilla G, Ruffolo C, Bonariol R, Maccatrozzo P, Tuci F, Battistella G, Grazi GL and Bassi N: Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases. Mol Clin Oncol 7: 529-538, 2017.
APA
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F. ... Bassi, N. (2017). Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases. Molecular and Clinical Oncology, 7, 529-538. https://doi.org/10.3892/mco.2017.1358
MLA
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F., Battistella, G., Grazi, G. L., Bassi, N."Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases". Molecular and Clinical Oncology 7.4 (2017): 529-538.
Chicago
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F., Battistella, G., Grazi, G. L., Bassi, N."Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases". Molecular and Clinical Oncology 7, no. 4 (2017): 529-538. https://doi.org/10.3892/mco.2017.1358
Copy and paste a formatted citation
x
Spandidos Publications style
Massani M, Capovilla G, Ruffolo C, Bonariol R, Maccatrozzo P, Tuci F, Battistella G, Grazi GL and Bassi N: Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases. Mol Clin Oncol 7: 529-538, 2017.
APA
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F. ... Bassi, N. (2017). Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases. Molecular and Clinical Oncology, 7, 529-538. https://doi.org/10.3892/mco.2017.1358
MLA
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F., Battistella, G., Grazi, G. L., Bassi, N."Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases". Molecular and Clinical Oncology 7.4 (2017): 529-538.
Chicago
Massani, M., Capovilla, G., Ruffolo, C., Bonariol, R., Maccatrozzo, P., Tuci, F., Battistella, G., Grazi, G. L., Bassi, N."Blood transfusions and steatohepatitis are independent risk factors for complications following liver resection for colorectal cancer liver metastases". Molecular and Clinical Oncology 7, no. 4 (2017): 529-538. https://doi.org/10.3892/mco.2017.1358
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