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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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October-2017 Volume 7 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Case Report

Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report

  • Authors:
    • Kaname Sakuma
    • Ryuki Tamura
    • Naoto Noda
    • Masutaka Mizutani
    • Akira Yamaguchi
    • Akira Tanaka
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Niigata Hospital, The Nippon Dental University, Niigata 951‑8580, Japan, Department of Oral and Maxillofacial Surgery, The Nippon Dental University School of Life Dentistry at Niigata, Niigata 951‑8580, Japan
  • Pages: 637-641
    |
    Published online on: August 8, 2017
       https://doi.org/10.3892/mco.2017.1367
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Abstract

In vitro anticancer drug sensitivity assessments have been performed for various types of cancer, and an association with clinical response has been observed. The collagen gel droplet‑embedded culture drug sensitivity test (CD‑DST) is an in vitro anticancer drug sensitivity test that has recently reported to be useful in oral squamous cell carcinoma (OSCC). CD‑DST allows for the analysis of a smaller number of cells compared with other anticancer drug sensitivity tests. The present study reported a successful analysis of anticancer drug sensitivity using CD‑DST on cervical lymph node tissue dissected following neoadjuvant chemotherapy from a 55‑year‑old man with advanced hard palate cancer. Tumor resection and bilateral neck dissection were performed following neoadjuvant chemotherapy (docetaxel + cisplatin + 5‑fluorouracil; TPF) for hard palate cancer T2N2cM0. Local recurrence and cervical multiple skin metastasis occurred ~8 months after surgery, and the patient received six doses of cetuximab (C‑mab) + cisplatin + 5‑fluorouracil (C‑mab + PF) administration, which is a type of molecular‑targeted therapy. Following the use of the CD‑DST method, the clinical response was noted as stable disease following execution of TPF and partial response following execution of C‑mab + PF. In addition, low sensitivity by TPF and high sensitivity by C‑mab + PF were reported. The CD‑DST method reflected the clinical response for the patient, and the results of the current study indicate that CD‑DST is a useful tool for selecting chemotherapeutic drugs for patients with OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Sakuma K, Tamura R, Noda N, Mizutani M, Yamaguchi A and Tanaka A: Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Mol Clin Oncol 7: 637-641, 2017.
APA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., & Tanaka, A. (2017). Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Molecular and Clinical Oncology, 7, 637-641. https://doi.org/10.3892/mco.2017.1367
MLA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7.4 (2017): 637-641.
Chicago
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7, no. 4 (2017): 637-641. https://doi.org/10.3892/mco.2017.1367
Copy and paste a formatted citation
x
Spandidos Publications style
Sakuma K, Tamura R, Noda N, Mizutani M, Yamaguchi A and Tanaka A: Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Mol Clin Oncol 7: 637-641, 2017.
APA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., & Tanaka, A. (2017). Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report. Molecular and Clinical Oncology, 7, 637-641. https://doi.org/10.3892/mco.2017.1367
MLA
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7.4 (2017): 637-641.
Chicago
Sakuma, K., Tamura, R., Noda, N., Mizutani, M., Yamaguchi, A., Tanaka, A."Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer‑predicted antitumor efficacy of cetuximab: A case report". Molecular and Clinical Oncology 7, no. 4 (2017): 637-641. https://doi.org/10.3892/mco.2017.1367
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