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Article

There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival

  • Authors:
    • Chengdi Wang
    • Yang Liu
    • Jian Zhou
    • Lei Ye
    • Nan Chen
    • Min Zhu
    • Yulin Ji
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Vascular Surgery, West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Thoracic Surgery, West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 579-590
    |
    Published online on: August 14, 2017
       https://doi.org/10.3892/mco.2017.1376
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Abstract

Breast cancer is the most common diagnosed cancer among females worldwide. Superoxide dismutase 2 (SOD2), an antioxidant enzyme, may break the balance between the oxidant and antioxidant system to induce various diseases. The present study aimed to clarify the association between the SOD2 Val‑16Ala polymorphism and breast cancer risk or survival. Thus, a meta‑analysis of the relevant articles retrieved from PubMed and EMBASE databases was conducted to illuminate the association with odd ratios (ORs) or hazards ratios (HRs). A total of 26 eligible publications (n=38,008) were available in risk analysis and eight publications (n=5,746) in survival analysis. The results demonstrated a marginal association between breast cancer risk and SOD2 polymorphism in Caucasian patients [TT vs. CT + CC: (OR, 0.94; 95% confidence interval (CI), 0.88‑1.00)]. However, no other positive results were observed in risk and survival of breast cancer in the whole study [T vs. C: (OR, 0.99; 95% CI, 0.96‑1.02); CT vs. CC: (OR, 1.00; 95% CI, 0.95‑1.05); TT vs. CC: (OR, 0.98; 95% CI, 0.92‑1.05); TT vs. CT + CC: (OR, 1.00; 95% CI, 0.95‑1.05); CT + TT vs. CC: (OR, 0.99; 95% CI, 0.95‑1.05)]. The present meta‑analysis indicated that there was no significant relationship between SOD2 Val‑16Ala polymorphism and breast cancer risk or survival, although in Caucasian patients, the SOD2 TT genotype may marginally decrease the risk of breast cancer in comparison to the CT + CC genotype.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Liu Y, Zhou J, Ye L, Chen N, Zhu M and Ji Y: There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival. Mol Clin Oncol 7: 579-590, 2017.
APA
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., & Ji, Y. (2017). There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival. Molecular and Clinical Oncology, 7, 579-590. https://doi.org/10.3892/mco.2017.1376
MLA
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., Ji, Y."There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival". Molecular and Clinical Oncology 7.4 (2017): 579-590.
Chicago
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., Ji, Y."There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival". Molecular and Clinical Oncology 7, no. 4 (2017): 579-590. https://doi.org/10.3892/mco.2017.1376
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Liu Y, Zhou J, Ye L, Chen N, Zhu M and Ji Y: There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival. Mol Clin Oncol 7: 579-590, 2017.
APA
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., & Ji, Y. (2017). There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival. Molecular and Clinical Oncology, 7, 579-590. https://doi.org/10.3892/mco.2017.1376
MLA
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., Ji, Y."There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival". Molecular and Clinical Oncology 7.4 (2017): 579-590.
Chicago
Wang, C., Liu, Y., Zhou, J., Ye, L., Chen, N., Zhu, M., Ji, Y."There is no relationship between SOD2 Val-16Ala polymorphism and breast cancer risk or survival". Molecular and Clinical Oncology 7, no. 4 (2017): 579-590. https://doi.org/10.3892/mco.2017.1376
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