Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 7 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors

  • Authors:
    • Wen'e Cai
    • Xiaoyu Chen
    • Qingdong Pan
    • Shijun Zhang
    • Luojiao Tan
    • Xuyong Sun
    • Renbin Huang
    • Aijun Xia
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacy, 303 Hospital of PLA, Nanning, Guangxi 530021, P.R. China, Department of Pharmacology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Diagnosis, Administration of Old Officer of Beiji Temple, Beijing 100191, P.R. China, Guangxi Key Laboratory for Transplantation Medicine, Institute of Transplantation Medicine, 303 Hospital of PLA, Nanning, Guangxi 530021, P.R. China
  • Pages: 716-720
    |
    Published online on: August 16, 2017
       https://doi.org/10.3892/mco.2017.1378
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sarcoma is one of the most prevalent pediatric tumors and the therapeutic role of chemotherapy has yet to be elucidated. It has been reported that extracts of Longyanshen (Yulangsan) may enhance the sensitivity of drug‑resistant cancer cell lines, and improve the immune dysfunction induced by cyclophosphamide (CTX) in mice. The present in vivo study investigated the antitumor effects of Yulangsan polysaccharides (YLSPS) and their interaction with CTX in murine sarcoma 180 (S180)‑bearing mice. Immunohistochemistry was used to detect the expression of apoptosis‑related proteins. The ultrastructure of sarcoma cells was examined by transmission electron microscopy and the tumor growth rate was determined by measuring the tumor weight. A dose‑dependent inhibition of sarcoma growth was observed in S180‑bearing mice following administration of YLSPS. In combination with CTX, an additive antitumor effect was obtained, which was accompanied by amelioration of immune function. YLSPS also potentiated the tumor suppression effect of CTX while avoiding cytotoxicity against immune cells. YLSPS inhibited sarcoma growth in S180‑bearing mice through the induction of apoptosis in S180 sarcoma cells. YLSPS also attenuated CTX‑induced cytotoxicity to the immune system while potentiating the tumor suppression effect. These results provide additional information regarding combination therapy with YLSPS and chemotherapy for the treatment of sarcoma.
View Figures

Figure 1

Figure 2

View References

1 

Lewin J, Puri A, Quek R, Ngan R, Alcasabas AP, Wood D and Thomas D: Management of sarcoma in the Asia-Pacific region: Resource-stratified guidelines. Lancet Oncol. 14:e562–e570. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Forscher C, Mita M and Figlin R: Targeted therapy for sarcomas. Biologics. 8:91–105. 2014.PubMed/NCBI

3 

Italiano A, Penel N, Robin YM, Bui B, Le Cesne A, Piperno-Neumann S, Tubiana-Hulin M, Bompas E, Chevreau C, Isambert N, et al: Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: A study of the French Sarcoma Group. Ann Oncol. 20:425–430. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Woll PJ, Reichardt P, Le Cesne A, Bonvalot S, Azzarelli A, Hoekstra HJ, Leahy M, Van Coevorden F, Verweij J, Hogendoorn PC, et al: Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): A multicentre randomised controlled trial. Lancet Oncol. 13:1045–1054. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A and Ghert M: A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 113:573–581. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Bramwell VH, Anderson D and Charette ML: Sarcoma Disease Site Group: Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma. Cochrane Database Syst Rev: CD003293. 2003. View Article : Google Scholar

7 

Region DoPHoGZA: Guangxi Chinese Materia Medica Standards. Guangxi Kexue Jishu Publishing House, Guangxi Zhuang Autonomous Region. 1990.(In Chinese).

8 

Kong X, Jiang W and Lin Z: Reversal effect of extract from Longyanshen on the resistance of human cancer cells MCF-7/ADR and KB/MIT. J Guangxi Med Univ. 20:495–496. 2003.(In Chinese).

9 

Kong X, Jiang W and Lin Z: Effect of extract of Longyanshen (EL) on immunodepression induced by cyclophosphamide in mice. China Pharmacy. 15:335–336. 2004.(In Chinese).

10 

Lin X, Huang Z, Chen X, Rong Y, Zhang S, Jiao Y, Huang Q and Huang R: Protective effect of Millettia pulchra polysaccharide on cognitive impairment induced by D-galactose in mice. Carbohydr Polym. 101:533–543. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Wiens GD, Vallejo RL, Leeds TD, Palti Y, Hadidi S, Liu S, Evenhuis JP, Welch TJ and Rexroad CE III: Assessment of genetic correlation between bacterial cold water disease resistance and spleen index in a domesticated population of rainbow trout: Identification of QTL on chromosome Omy19. PLoS One. 8:e757492013. View Article : Google Scholar : PubMed/NCBI

12 

Fang JJ, Zhu ZY, Dong H, Zheng GQ, Teng AG and Liu AJ: Effect of spleen lymphocytes on the splenomegaly in hepatocellular carcinoma-bearing mice. Biomed Environ Sci. 27:17–26. 2014.PubMed/NCBI

13 

Decastel M, Ossondo M, Andrea AM, Tressieres B, Veronique-Baudin J, Deloumeaux J, Lubeth M and Smith-Ravin J: Colorectal cancer in patients seen at the teaching hospitals of Guadeloupe and Martinique: Discrepancies, similarities in clinicopathological features, and p53 status. BMC Clin Pathol. 14:122014. View Article : Google Scholar : PubMed/NCBI

14 

Alonso-Castro AJ, Ortiz-Sánchez E, Domínguez F, Arana-Argáez V, Juárez-Vázquez Mdel C, Chávez M, Carranza-Álvarez C, Gaspar-Ramírez O, Espinosa-Reyes G, López-Toledo G, et al: Antitumor and immunomodulatory effects of Justicia spicigera Schltdl (Acanthaceae). J Ethnopharmacol. 141:888–894. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Liu J, Su F and Sun J: The synergistic effect and mechanism of Agaricus blazei polysaccharides compound and Cytoxan. Chin J Clin Rehabil. 10:118–121. 2006.(In Chinese).

16 

Cormier JN and Pollock RE: Soft tissue sarcomas. CA Cancer J Clin. 54:94–109. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Wibmer C, Leithner A, Zielonke N, Sperl M and Windhager R: Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review. Ann Oncol. 21:1106–1111. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Dai LJ, Moniri MR, Zeng ZR, Zhou JX, Rayat J and Warnock GL: Potential implications of mesenchymal stem cells in cancer therapy. Cancer Lett. 305:8–20. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Sun XY, Nong J, Qin K, Warnock GL and Dai LJ: Mesenchymal stem cell-mediated cancer therapy: A dual-targeted strategy of personalized medicine. World J Stem Cells. 3:96–103. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Wang PY, Zhu XL and Lin ZB: Antitumor and immunomodulatory effects of polysaccharides from broken-spore of ganoderma lucidum. Front Pharmacol. 3:1352012. View Article : Google Scholar : PubMed/NCBI

21 

Zhang S, Nie S, Huang D, Huang J, Wang Y and Xie M: Polysaccharide from Ganoderma atrum evokes antitumor activity via Toll-like receptor 4-mediated NF-κB and mitogen-activated protein kinase signaling pathways. J Agric Food Chem. 61:3676–3682. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Ni W, Zhang X, Wang B, Chen Y, Han H, Fan Y, Zhou Y and Tai G: Antitumor activities and immunomodulatory effects of ginseng neutral polysaccharides in combination with 5-fluorouracil. J Med Food. 13:270–277. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cai W, Chen X, Pan Q, Zhang S, Tan L, Sun X, Huang R and Xia A: Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors. Mol Clin Oncol 7: 716-720, 2017.
APA
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X. ... Xia, A. (2017). Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors. Molecular and Clinical Oncology, 7, 716-720. https://doi.org/10.3892/mco.2017.1378
MLA
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X., Huang, R., Xia, A."Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors". Molecular and Clinical Oncology 7.4 (2017): 716-720.
Chicago
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X., Huang, R., Xia, A."Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors". Molecular and Clinical Oncology 7, no. 4 (2017): 716-720. https://doi.org/10.3892/mco.2017.1378
Copy and paste a formatted citation
x
Spandidos Publications style
Cai W, Chen X, Pan Q, Zhang S, Tan L, Sun X, Huang R and Xia A: Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors. Mol Clin Oncol 7: 716-720, 2017.
APA
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X. ... Xia, A. (2017). Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors. Molecular and Clinical Oncology, 7, 716-720. https://doi.org/10.3892/mco.2017.1378
MLA
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X., Huang, R., Xia, A."Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors". Molecular and Clinical Oncology 7.4 (2017): 716-720.
Chicago
Cai, W., Chen, X., Pan, Q., Zhang, S., Tan, L., Sun, X., Huang, R., Xia, A."Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors". Molecular and Clinical Oncology 7, no. 4 (2017): 716-720. https://doi.org/10.3892/mco.2017.1378
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team