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Case Report Open Access

A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report

  • Authors:
    • Masaru Miyazaki
    • Mikiko Aoki
    • Satoru Oba
    • Toshifumi Sakata
    • Takashi Nakagawa
    • Kazuki Nabeshima
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814‑0180, Japan, Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University School of Medicine, Fukuoka 814‑0180, Japan
    Copyright: © Miyazaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 539-542
    |
    Published online on: August 18, 2017
       https://doi.org/10.3892/mco.2017.1379
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Abstract

Sarcoma is an uncommon histopathological presentation of sinonasal tumors, comprising ~15% of all cases; liposarcoma is particularly uncommon. An analysis of the available medical literature revealed no prior reports of dedifferentiated liposarcoma (DDLPS) of the sinonasal cavity. This case report presents a rare case of DDLPS of the sinonasal cavity. A 40‑year old six‑week pregnant female was admitted with a left nasal obstruction. Endoscopic evaluation of the left nasal cavity revealed a polypoid lesion. A computed tomography scan indicated a mass invading the left nasal cavity, maxillary sinus and anterior ethmoid sinus with focal destruction of the surrounding bone. A biopsy of the tumor was performed and hematoxylin and eosin staining of the tissue sections revealed proliferation of atypical and pleomorphic spindle cells with enlarged or elongated hyperchromatic nuclei and occasional vacuolated cytoplasm arranged in short interlacing fascicles or storiform structures, accompanied by tumor necrosis. These findings were consistent with undifferentiated pleomorphic sarcoma. Immunohistochemically, the tumor cells were positive for cyclin dependent kinase 4, mouse double minute 2 homolog (MDM2) and adipophilin. Fluorescence in situ hybridization (FISH) analysis revealed amplification of the MDM2 gene. Recently, undifferentiated pleomorphic sarcoma without areas of well‑differentiated liposarcoma but with MDM2 amplification is regarded as conventional DDLPS. In the present case, the tumor was diagnosed as a DDLPS due to the results of histopathological, immunohistochemical and FISH analysis.
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Copy and paste a formatted citation
Spandidos Publications style
Miyazaki M, Aoki M, Oba S, Sakata T, Nakagawa T and Nabeshima K: A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. Mol Clin Oncol 7: 539-542, 2017.
APA
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., & Nabeshima, K. (2017). A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. Molecular and Clinical Oncology, 7, 539-542. https://doi.org/10.3892/mco.2017.1379
MLA
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., Nabeshima, K."A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report". Molecular and Clinical Oncology 7.4 (2017): 539-542.
Chicago
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., Nabeshima, K."A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report". Molecular and Clinical Oncology 7, no. 4 (2017): 539-542. https://doi.org/10.3892/mco.2017.1379
Copy and paste a formatted citation
x
Spandidos Publications style
Miyazaki M, Aoki M, Oba S, Sakata T, Nakagawa T and Nabeshima K: A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. Mol Clin Oncol 7: 539-542, 2017.
APA
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., & Nabeshima, K. (2017). A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report. Molecular and Clinical Oncology, 7, 539-542. https://doi.org/10.3892/mco.2017.1379
MLA
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., Nabeshima, K."A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report". Molecular and Clinical Oncology 7.4 (2017): 539-542.
Chicago
Miyazaki, M., Aoki, M., Oba, S., Sakata, T., Nakagawa, T., Nabeshima, K."A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case report". Molecular and Clinical Oncology 7, no. 4 (2017): 539-542. https://doi.org/10.3892/mco.2017.1379
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