Gastrointestinal tract‑like muscular walls in ovarian mature cystic teratomas: A histopathological study

Matsukuma,Susumu; Takahashi,Oh; Utsumi,Yoshitaka; Miyai,Kosuke; Takeo,Hiroaki

doi:10.3892/mco.2017.1381

October-2017 Volume 7 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October-2017 Volume 7 Issue 4

Full Size Image

Article

Gastrointestinal tract‑like muscular walls in ovarian mature cystic teratomas: A histopathological study

Authors:
- Susumu Matsukuma
- Oh Takahashi
- Yoshitaka Utsumi
- Kosuke Miyai
- Hiroaki Takeo
View Affiliations / Copyright

Affiliations: Department of Pathology, Japan Self‑Defense Forces Central Hospital, Tokyo 154‑8532, Japan
Pages: 642-648
|
Published online on: August 18, 2017

https://doi.org/10.3892/mco.2017.1381
Expand metrics +

Abstract

To elucidate the frequency and histopathological features of gastrointestinal (GI) tract‑like muscular walls developing in ovarian mature cystic teratoma (MCT), the present study examined 149 MCTs surgically removed from 126 females, including 23 bilateral cases. GI tract‑like muscular walls were identified in 9 (7.1%) cases, and were accompanied by mucosa in 5 cases, muscularis mucosae in 5 cases, serosa in 5 cases and all of these components in 3 cases. The mean size of the GI tract‑like structures was 0.6 cm. The presence of MCT‑related GI tract‑like muscular walls was not significantly associated with patient age, size of MCTs or bilateral presence of MCT. The detected mucosae and muscular walls commonly demonstrated incomplete or anomalous features. Immunohistochemically, a few weakly KIT+ spindle and/or stellate cells were identified in 7 cases (77.8% of the 9 cases of MCT‑related GI tracts); these cells were presented chiefly near conspicuous or inconspicuous S‑100 protein+ neural tissues between the conspicuous or inconspicuous two muscular wall layers, indicating interstitial cells of Cajal (ICCs). Discovered on gastrointestinal stromal tumors 1 co‑expression in KIT+ ICCs was observed in only 1 case. Neural cell‑related intramuscular cluster of differentiation 34+ cells were occasionally observed; however, no hyperplastic ICCs were observed in the present study.

View Figures

View References

1	Scully RE, Young RH and Clement PB: Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. In: Atlas of Tumor Pathology. 3rd edition. fascicle 23Rosai J and Sobin LH: American Registry of Pathology. Washington: 1998
2	Russel P and Bannatyne P: Surgical Pathology of the Ovaries. Churchill Livingstone; New York, NY: pp. 416–452. 1989
3	Rosai J: Rosai and Ackerman's Surgical Pathology. 10th. Mosby/Elsevier; Philadelphia, PA: 2011, View Article : Google Scholar
4	Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO Classification of Tumours of Female Reproductive Organs. 4th. IARC Press; Lyon: pp. 60–61. 2014
5	Gundersen JH and Greene RR: Vermiform appendix in benign cystic teratoid tumor of the ovary. Am J Obstet Gynecol. 89:534–535. 1964. View Article : Google Scholar : PubMed/NCBI
6	Woodfield B, Kats DA, Cantrell CJ and Bogard PJ: A benign cystic teratoma with gastrointestinal tract development. Am J Clin Pathol. 83:236–240. 1985. View Article : Google Scholar : PubMed/NCBI
7	Sahin AA, Ro JY, Chen J and Ayala AG: Spindle cell nodule and peptic ulcer arising in a fully developed gastric wall in a mature cystic teratoma. Arch Pathol Lab Med. 114:529–531. 1990.PubMed/NCBI
8	Fujiwara K, Ginzan S and Silverberg SG: Mature cystic teratomas of the ovary with intestinal wall structures harboring intestinal-type epithelial neoplasms. Gynecol Oncol. 56:97–101. 1995. View Article : Google Scholar : PubMed/NCBI
9	Tang P, Soukkary S and Kahn E: Mature cystic teratoma of the ovary associated with complete colonic wall and mucinous cystadenoma. Ann Clin Lab Sci. 33:465–470. 2003.PubMed/NCBI
10	Ki EY, Jang DG, Jeong DJ, Kim CJ and Lee SJ: Rare case of complete colon structure in a mature cystic teratoma of the ovary in menopausal woman: A case report. BMC Women's Health. 16:702016. View Article : Google Scholar : PubMed/NCBI
11	Agaimy A, Lindner M and Wuensch PH: Interstitial cells of Cajal (ICC) in mature cystic teratoma of the ovary. Histopathology. 48:208–209. 2006. View Article : Google Scholar : PubMed/NCBI
12	Agaimy A and Wünsch PH: Coexistence of interstitial cell of Cajal hyperplasia and microcarcinoidosis in a mature cystic teratoma. Histopathology. 52:260–262. 2008.PubMed/NCBI
13	Blackwell WJ, Dockerty MB, Masson JC and Mussey RD: Dermoid cysts of the ovary: Their clinical and pathologic significance. Am J Obstet Gynecol. 51:151–172. 1946. View Article : Google Scholar : PubMed/NCBI
14	Mills SE: Histology for pathologists. 4th. Lippincott Williams & Wilkins; Philadelphia PA: pp. 605–708, pp1255-1276. 2012
15	Espinosa I, Lee CH, Kim MK, Rouse BT, Subramanian S, Montgomery K, Varma S, Corless CL, Heinrich MC, Smith KS, et al: A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal tumors. Am J Surg Pathol. 32:210–218. 2008. View Article : Google Scholar : PubMed/NCBI
16	Miettinen M, Wang ZF and Lasota J: DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors. A study of 1840 cases. Am J Surg Pathol. 33:1401–1408. 2009. View Article : Google Scholar : PubMed/NCBI
17	Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: WHO Classification of Tumours of Soft tissues and Bone. 4th. IARC Press; Lyon: pp. 170–186. 2013
18	Dabbs: Diagnostic immunohistochemistry. 2nd. Churchill Livingston/Elsevier; Philadelphia, PA: pp. 2632006
19	Hirota S and Isozaki K: Pathology of gastrointestinal stromal tumors. Pathol Int. 56:1–9. 2006. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gastrointestinal tract‑like muscular walls in ovarian mature cystic teratomas: A histopathological study

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles