Claudin‑1 expression in cervical cancer

Hoellen,Friederike; Waldmann,Annika; Banz‑Jansen,Constanze; Holtrich,Uwe; Karn,Thomas; Oberländer,Martina; Habermann,Jens K.; Hörmann,Mareike; Köster,Frank; Ribbat‑Idel,Julika; Thill,Marc; Rody,Achim; El‑Balat,Ahmed; Hanker,Lars

doi:10.3892/mco.2017.1391

November-2017 Volume 7 Issue 5

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November-2017 Volume 7 Issue 5

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Article

Claudin‑1 expression in cervical cancer

Authors:
- Friederike Hoellen
- Annika Waldmann
- Constanze Banz‑Jansen
- Uwe Holtrich
- Thomas Karn
- Martina Oberländer
- Jens K. Habermann
- Mareike Hörmann
- Frank Köster
- Julika Ribbat‑Idel
- Marc Thill
- Achim Rody
- Ahmed El‑Balat
- Lars Hanker
View Affiliations / Copyright

Affiliations: Department of Gynecology and Obstetrics, University of Lübeck, D‑23538 Lübeck, Germany, Institute for Social Medicine and Epidemiology, University of Lübeck, D‑23538 Lübeck, Germany, Department of Gynecology and Obstetrics, University Hospital Oldenburg, D‑26133 Oldenburg, Germany, Department of Obstetrics and Gynecology, Goethe‑University, D‑60590 Frankfurt, Germany, Section for Translational Surgical Oncology and Biobanking, Department of Surgery, University of Lübeck and University Medical Center Schleswig‑Holstein, Campus Lübeck, D‑23538 Lübeck, Germany, Institute for Pathology, University of Düsseldorf, D‑40225 Düsseldorf, Germany, Institute for Pathology, University of Lübeck, D‑23538 Lübeck, Germany, Department of Gynecology and Obstetrics, Agaplesion Markus Krankenhaus, D‑60431 Frankfurt, Germany
Pages: 880-884
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Published online on: August 25, 2017

https://doi.org/10.3892/mco.2017.1391
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Abstract

Claudin‑1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin‑1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin‑1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin‑1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin‑1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin‑1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin‑1‑negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin‑1‑negative patients. In order to elucidate whether claudin‑1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required.

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1	Cunniffe C, Ryan F, Lambkin H and Brankin B: Expression of tight and adherens junction proteins in cervical neoplasia. Br J Biomed Sci. 69:147–153. 2012.PubMed/NCBI
2	Kominsky SL: Claudins: Emerging targets for cancer therapy. Expert Rev Mol Med. 8:1–11. 2006. View Article : Google Scholar : PubMed/NCBI
3	Szabó I, Kiss A, Schaff Z and Sobel G: Claudins as diagnostic and prognostic markers in gynecological cancer. Histol Histopathol. 24:1607–1615. 2009.PubMed/NCBI
4	Swisshelm K, Macek R and Kubbies M: Role of claudins in tumorigenesis. Adv Drug Deliv Rev. 57:919–928. 2005. View Article : Google Scholar : PubMed/NCBI
5	Kwon MJ: Emerging roles of claudins in human cancer. Int J Mol Sci. 14:18148–18180. 2013. View Article : Google Scholar : PubMed/NCBI
6	Cunniffe C, Brankin B, Lambkin H and Ryan F: The role of claudin-1 and claudin-7 in cervical tumorigenesis. Anticancer Res. 34:2851–2857. 2014.PubMed/NCBI
7	Lee JW, Lee SJ, Seo J, Song SY, Ahn G, Park CS, Lee JH, Kim BG and Bae DS: Increased expressions of claudin-1 and claudin-7 during the progression of cervical neoplasia. Gynecol Oncol. 97:53–59. 2005. View Article : Google Scholar : PubMed/NCBI
8	Benczik M, Galamb Á, Koiss R, Kovács A, Járay B, Székely T, Szekerczés T, Schaff Z, Sobel G and Jeney C: Claudin-1 as a biomarker of cervical cytology and histology. Pathol Oncol Res. 22:179–188. 2016. View Article : Google Scholar : PubMed/NCBI
9	Oberländer M, Alkemade H, Bünger S, Ernst F, Thorns C, Braunschweig T and Habermann JK: A ‘waterfall’ transfer-based workflow for improved quality of tissue microarray construction and processing in breast cancer research. Pathol Oncol Res. 20:719–726. 2014. View Article : Google Scholar : PubMed/NCBI
10	Remmele W and Stegner HE: Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 8:138–140. 1987.(In German). PubMed/NCBI
11	Zhang WN, Li W, Wang XL, Hu Z, Zhu D, Ding WC, Liu D, Li KZ, Ma D and Wang H: CLDN1 expression in cervical cancer cells is related to tumor invasion and metastasis. Oncotarget. 7:87449–87461. 2016.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Claudin‑1 expression in cervical cancer

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