Claudin‑1 expression in cervical cancer
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- Published online on: August 25, 2017 https://doi.org/10.3892/mco.2017.1391
- Pages: 880-884
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Abstract
Claudin‑1 is a tight junction protein that has been demonstrated to be involved in tumorigenesis and tumor progression in various types of solid tumors. In the present study, the protein expression of claudin‑1 in squamous cervical cancer tissues obtained from 106 patients was analyzed by immunohistochemistry. In addition, the grade of claudin‑1 expression was analyzed for associations with certain clinicopathological parameters. A significant overexpression of claudin‑1 was detected in the tumor cells, when compared with that in the peritumoral stroma. There was no significant association between claudin‑1 expression and FIGO stage, tumor size, grading or the appearance of distant metastases. Cervical cancer patients scoring positive for claudin‑1 protein expression tended to exhibit more lymph node metastasis (28.3%), compared with claudin‑1‑negative patients (7.1%). Regarding overall survival, the results of the present study suggest a better prognosis for claudin‑1‑negative patients. In order to elucidate whether claudin‑1 overexpression has a significant prognostic impact on squamous cervical cancer, further studies are required.