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Molecular and Clinical Oncology
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Case Report

Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report

  • Authors:
    • Linna Xie
    • Fang Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The General Hospital of Jinan Military District, Jinan, Shandong 250031, P.R. China
  • Pages: 851-854
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/mco.2017.1414
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Abstract

Post‑transplantation lymphoproliferative disease (PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). The majority of the cases develop during the first year after the transplantation and are associated with reactivation of the Epstein‑Barr virus (EBV); the EBV‑induced lymphoproliferation usually includes donor‑derived B cells. We herein describe the case of a 28‑year‑old female patient who developed EBV‑negative PTLD, namely diffuse large B‑cell lymphoma (DLBCL), 6 months after receiving a haploidentical HSCT from her father. Chimerism analysis performed with XY fluorescence in situ hybridization revealed a B‑cell PTLD originating from the donor. Unfortunately, the donor also developed DLBCL 380 days after donating progenitor cells, although he was hematologically normal at the time of donation. The present case demonstrated that disease transmitted from the donor may be a possible cause of PTLD.
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Copy and paste a formatted citation
Spandidos Publications style
Xie L and Zhou F: Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report. Mol Clin Oncol 7: 851-854, 2017.
APA
Xie, L., & Zhou, F. (2017). Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report. Molecular and Clinical Oncology, 7, 851-854. https://doi.org/10.3892/mco.2017.1414
MLA
Xie, L., Zhou, F."Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report". Molecular and Clinical Oncology 7.5 (2017): 851-854.
Chicago
Xie, L., Zhou, F."Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report". Molecular and Clinical Oncology 7, no. 5 (2017): 851-854. https://doi.org/10.3892/mco.2017.1414
Copy and paste a formatted citation
x
Spandidos Publications style
Xie L and Zhou F: Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report. Mol Clin Oncol 7: 851-854, 2017.
APA
Xie, L., & Zhou, F. (2017). Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report. Molecular and Clinical Oncology, 7, 851-854. https://doi.org/10.3892/mco.2017.1414
MLA
Xie, L., Zhou, F."Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report". Molecular and Clinical Oncology 7.5 (2017): 851-854.
Chicago
Xie, L., Zhou, F."Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report". Molecular and Clinical Oncology 7, no. 5 (2017): 851-854. https://doi.org/10.3892/mco.2017.1414
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