Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2017 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 7 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis

  • Authors:
    • Wang Fugang
    • Yu Zhaopeng
    • Zhao Meng
    • Song Maomin
  • View Affiliations / Copyright

    Affiliations: The Fifth Clinical Medical College, Capital Medical University, Beijing 100069, P.R. China, Department of General Surgery, Beijing Tiantan Hospital, Beijing 100050, P.R. China
    Copyright: © Fugang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 771-776
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/mco.2017.1419
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The long-term outcome of laparoscopic surgery for geriatric patients with colorectal cancer remains unclear due to decreased functional reserves and increased medical comorbidities. A meta‑analysis was performed in the present study to compare the long-term outcome between laparoscopy and laparotomy. Randomized controlled trials and comparative studies regarding laparoscopy vs. open surgery for colorectal cancer in elderly patients were searched in Pubmed, Embase, and Cochrane library between inception and April 20, 2017. The methodological quality of the cohort studies was evaluated using the Newcastle‑Ottawa Scale. The meta‑analysis was performed using Stata v12.0 software. Eight cohort studies were enrolled in the meta‑analysis. Laparoscopic surgery was associated with a higher 3‑year survival rate compared with open surgery [risk ratio (RR), 0.74; 95% confidence interval (CI), 0.61‑0.90; P=0.003]. No significant difference was identified between laparoscopy and laparotomy regarding the 5‑year survival rate (RR, 0.93; 95% CI, 0.78‑1.11, P=0.424). The results of the meta‑analysis indicated that the use of laparoscopic surgery on geriatric patients with colorectal cancer should be increased due to more improved long-term outcomes. All the studies included in the meta‑analysis were case‑control studies with selection bias and other confounding factors. Thus, larger sample sizes and multicenter randomized controlled trials are required to further validate the use of laparoscopic surgery as the preferred therapeutic option for elderly patients with colorectal cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Winther Braendegaard S, Baatrup G, Pfeiffer P and Qvortrup C: Academy of Geriatric Cancer Research (AgeCare): Trends in colorectal cancer in the elderly in Denmark, 1980–2012. Acta Oncol. 55 Suppl 1:S29–S39. 2016. View Article : Google Scholar

3 

Hermans E, van Schaik PM, Prins HA, Ernst MF, Dautzenberg PJ and Bosscha K: Outcome of colonic surgery in elderly patients with colon cancer. J Oncol. 2010:8659082010. View Article : Google Scholar : PubMed/NCBI

4 

Bayar R, Mzoughi Z, Djebbi A, Halek G and Khalfallah MT: Laparoscopic colectomy versus colectomy performed via laparotomy in the treatment of non-metastatic colic adenocarcinomas. Pan Afr Med J. 25:1652016.(In French). View Article : Google Scholar : PubMed/NCBI

5 

Bonjer HJ, Deijen CL, Abis GA, Cuesta MA, van der Pas MH, de Lange-de Klerk ES, Lacy AM, Bemelman WA, Andersson J, Angenete E, et al: A randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med. 372:1324–1332. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Grailey K, Markar SR, Karthikesalingam A, Aboud R, Ziprin P and Faiz O: Laparoscopic versus open colorectal resection in the elderly population. Surg Endosc. 27:19–30. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Li Y, Wang S, Gao S, Yang C, Yang W and Guo S: Laparoscopic colorectal resection versus open colorectal resection in octogenarians: A systematic review and meta-analysis of safety and efficacy. Tech Coloproctol. 20:153–162. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Xie M, Qin H, Luo Q, He X, Lan P and Lian L: laparoscopic colorectal resection in octogenarian patients: Is it Safe? A systematic review and meta-analysis. Medicine (Baltimore). 94:e17652015. View Article : Google Scholar : PubMed/NCBI

9 

Altuntas YE, Gezen C, Vural S, Okkabaz N, Kement M and Oncel M: Laparoscopy for sigmoid colon and rectal cancers in septuagenarians: A retrospective, comparative study. Tech Coloproctol. 16:213–219. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Cummings LC, Delaney CP and Cooper GS: Laparoscopic versus open colectomy for colon cancer in an older population: A cohort study. World J Surg Oncol. 10:312012. View Article : Google Scholar : PubMed/NCBI

11 

Hinoi T, Kawaguchi Y, Hattori M, Okajima M, Ohdan H, Yamamoto S, Hasegawa H, Horie H, Murata K, Yamaguchi S, et al: Laparoscopic versus open surgery for colorectal cancer in elderly patients: A multicenter matched case-control study. Ann Surg Oncol. 22:2040–2050. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Moon SY, Kim S, Lee SY, Han EC, Kang SB, Jeong SY, Park KJ and Oh JH: SEoul COlorectal Group (SECOG): Laparoscopic surgery for patients with colorectal cancer produces better short-term outcomes with similar survival outcomes in elderly patients compared to open surgery. Cancer Med. 5:1047–1054. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Robinson CN, Balentine CJ, Marshall CL, Wilks JA, Anaya D, Artinyan A, Berger DH and Albo D: Minimally invasive surgery improves short-term outcomes in elderly colorectal cancer patients. J Surg Res. 166:182–188. 2011. View Article : Google Scholar : PubMed/NCBI

14 

She WH, Poon JT, Fan JK, Lo OS and Law WL: Outcome of laparoscopic colectomy for cancer in elderly patients. Surg Endosc. 27:308–312. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Shigeta K, Baba H, Yamafuji K, Asami A, Takeshima K, Nagasaki K, Okamoto N, Murata T, Arai S, Kubochi K and Kitagawa Y: Effects of laparoscopic surgery on the patterns of death in elderly colorectal cancer patients: Competing risk analysis compared with open surgery. Surg Today. 46:422–429. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Zeng WG, Zhou ZX, Hou HR, Liang JW, Zhou HT, Wang Z, Zhang XM and Hu JJ: Outcome of laparoscopic versus open resection for rectal cancer in elderly patients. J Surg Res. 193:613–618. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Christensen K, Doblhammer G, Rau R and Vaupel JW: Ageing populations: The challenges ahead. Lancet. 374:1196–1208. 2009. View Article : Google Scholar : PubMed/NCBI

18 

van der Pas MH, Haglind E, Cuesta MA, Fürst A, Lacy AM, Hop WC and Bonjer HJ: COlorectal cancer Laparoscopic or Open Resection II (COLOR II) Study Group: Laparoscopic versus open surgery for rectal cancer (COLOR II): Short-term outcomes of a randomised, phase 3 trial. Lancet Oncol. 14:210–218. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Yamamoto S, Inomata M, Katayama H, Mizusawa J, Etoh T, Konishi F, Sugihara K, Watanabe M, Moriya Y and Kitano S: Japan Clinical Oncology Group Colorectal Cancer Study Group: Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404. Ann Surg. 260:23–30. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Jeong SY, Park JW, Nam BH, Kim S, Kang SB, Lim SB, Choi HS, Kim DW, Chang HJ, Kim DY, et al: Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): Survival outcomes of an open-label, non-inferiority, randomised controlled trial. Lancet Oncol. 15:767–774. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Niitsu H, Hinoi T, Kawaguchi Y, Ohdan H, Hasegawa H, Suzuka I, Fukunaga Y, Yamaguchi T, Endo S, Tagami S, et al: Laparoscopic surgery for colorectal cancer is safe and has survival outcomes similar to those of open surgery in elderly patients with a poor performance status: Subanalysis of a large multicenter case-control study in Japan. J Gastroenterol. 51:43–54. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Koh FH, Wong J, Tan JK, Tan KK, Cheong WK and Lieske B: Laparoscopic colorectal surgery is safe and benefits octogenarian patients with malignant disease: A matched case-control study comparing laparoscopic and open colorectal surgery. Int J Colorectal Dis. 30:963–968. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kim DH, Kim IY, Kim BR and Kim YW: Factors affecting the selection of minimally invasive surgery for stage 0/I colorectal cancer. Int J Surg. 16:44–48. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Jiang JB, Jiang K, Wang JJ, Dai Y, Xie FB and Li XM: Short-term and long-term outcomes regarding laparoscopic versus open surgery for low rectal cancer: A systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 25:286–296. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Feinberg AE, Chesney TR, Acuna SA, Sammour T and Quereshy FA: Oncologic outcomes following laparoscopic versus open resection of pT4 colon cancer: A systematic review and meta-analysis. Dis Colon Rectum. 60:116–125. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Miyasaka Y, Mochidome N, Kobayashi K, Ryu S, Akashi Y and Miyoshi A: Efficacy of laparoscopic resection in elderly patients with colorectal cancer. Surg Today. 44:1834–1840. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Nakamura T, Sato T, Miura H, Ikeda A, Tsutsui A, Naito M, Ogura N and Watanabe M: Feasibility and outcomes of surgical therapy in very elderly patients with colorectal cancer. Surg Laparosc Endosc Percutan Tech. 24:85–88. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Tominaga T, Takeshita H, Arai J, Takagi K, Kunizaki M, To K, Abo T, Hidaka S, Nanashima A, Nagayasu T and Sawai T: Short-term outcomes of laparoscopic surgery for colorectal cancer in oldest-old patients. Dig Surg. 32:32–38. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fugang W, Zhaopeng Y, Meng Z and Maomin S: Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis. Mol Clin Oncol 7: 771-776, 2017.
APA
Fugang, W., Zhaopeng, Y., Meng, Z., & Maomin, S. (2017). Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis. Molecular and Clinical Oncology, 7, 771-776. https://doi.org/10.3892/mco.2017.1419
MLA
Fugang, W., Zhaopeng, Y., Meng, Z., Maomin, S."Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis". Molecular and Clinical Oncology 7.5 (2017): 771-776.
Chicago
Fugang, W., Zhaopeng, Y., Meng, Z., Maomin, S."Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis". Molecular and Clinical Oncology 7, no. 5 (2017): 771-776. https://doi.org/10.3892/mco.2017.1419
Copy and paste a formatted citation
x
Spandidos Publications style
Fugang W, Zhaopeng Y, Meng Z and Maomin S: Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis. Mol Clin Oncol 7: 771-776, 2017.
APA
Fugang, W., Zhaopeng, Y., Meng, Z., & Maomin, S. (2017). Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis. Molecular and Clinical Oncology, 7, 771-776. https://doi.org/10.3892/mco.2017.1419
MLA
Fugang, W., Zhaopeng, Y., Meng, Z., Maomin, S."Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis". Molecular and Clinical Oncology 7.5 (2017): 771-776.
Chicago
Fugang, W., Zhaopeng, Y., Meng, Z., Maomin, S."Long-term outcomes of laparoscopy vs. open surgery for colorectal cancer in elderly patients: A meta‑analysis". Molecular and Clinical Oncology 7, no. 5 (2017): 771-776. https://doi.org/10.3892/mco.2017.1419
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team