Schwannoma of the vagina - a common tumor but a rare location: A case report

An,Xin; Zhu,Meng; Zhang,Ning; Lu,Sanjun; Wei,Pin; Jiang,Linna; Yang,Xueli

doi:10.3892/mco.2017.1420

November-2017 Volume 7 Issue 5

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November-2017 Volume 7 Issue 5

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Case Report Open Access

Schwannoma of the vagina - a common tumor but a rare location: A case report

Authors:
- Xin An
- Meng Zhu
- Ning Zhang
- Sanjun Lu
- Pin Wei
- Linna Jiang
- Xueli Yang
View Affiliations / Copyright

Affiliations: Department of Pathology, Handan First Hospital, Handan, Hebei 056002, P.R. China, Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China

Copyright: © An et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 783-786
|
Published online on: September 19, 2017

https://doi.org/10.3892/mco.2017.1420
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Abstract

Schwannomas are nerve sheath tumors arising from Schwann cells. These tumors usually present as benign, relatively slow-growing, solitary, encapsulated, painless masses. Schwannomas rarely occur in the vagina, and have not been fully recognized as gynecological tumors. We herein describe the case of a patient who presented with a schwannoma occurring in the wall of vagina, with non-specific symptoms lasting for ~1 year. The vaginal mass was incidentally detected during a sonographic examination and the patient was referred for surgical resection. The surgery was uncomplicated and the vaginal tumor was diagnosed as benign schwannoma. The immunohistochemical examination revealed positivity for vimentin, S-100 and glial fibrillary acidic protein, whereas discovered on GIST-1, CD117, CD34, desmin, smooth muscle actin and cytokeratin were negative. Tumors occurring in the vagina are common and are of variable histological types, with a wide range of pathological characteristics and complications. Schwannoma should be considered in the differential diagnosis in patients presenting with atypical symptoms from the gynecological tract. Immunohistochemical staining is required for confirmation of the diagnosis of schwannoma, and for distinguishing this entity from other homologous tumors.

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1	Hilton DA and Hanemann CO: Schwannomas and their pathogenesis. Brain Pathol. 24:205–220. 2014. View Article : Google Scholar : PubMed/NCBI
2	Berlucchi M, Piazza C, Blanzuoli L, Battaglia G and Nicolai P: Schwannoma of the nasal septum: a case report with review of the literature. Eur Arch Otorhinolaryngol. 257:402–405. 2000. View Article : Google Scholar : PubMed/NCBI
3	Hanemann CO and Evans DG: News on the genetics, epidemiology, medical care and translational research of Schwannomas. J Neurol. 253:1533–1541. 2006. View Article : Google Scholar : PubMed/NCBI
4	Abreu I, Roriz D, Rodrigues P, Moreira A, Marques C and Alves FC: Schwannoma of the tongue-A common tumour in a rare location: A case report. Eur J Radiol Open. 4:1–3. 2017. View Article : Google Scholar : PubMed/NCBI
5	Romdhane H, Cheikh M, Mzoughi Z, Slama SB, Ennaifer R and Belhadj N: Gastric Schwannoma: A Case Report. Clin Pract. 6:8492016. View Article : Google Scholar : PubMed/NCBI
6	Wang WB, Chen WB, Lin JJ, Xu JH, Wang JH and Sheng QS: Schwannoma of the colon: A case report and review of the literature. Oncol Lett. 11:2580–2582. 2016.PubMed/NCBI
7	Öz TT, Aktaş B, Özkan K, Özturan B, Kilic B and Demiroğlu M: A Case of Schwannoma of the Common Peroneal Nerve in the Knee. Orthop Rev (Pavia). 9:68252017. View Article : Google Scholar : PubMed/NCBI
8	Loeser A, Katzenberger T, Meuller JG, Riedmiller H and Gerharz EW: Solitary schwannoma of the glans penis. Urology. 70:1007.e5–1007.e6. 2007. View Article : Google Scholar
9	Biswas D, Marnane CN, Mal R and Baldwin D: Extracranial head and neck schwannomas-a 10-year review. Auris Nasus Larynx. 34:353–359. 2007. View Article : Google Scholar : PubMed/NCBI
10	Hornick JL and Fletcher CD: Cellular neurothekeoma: Detailed characterization in a series of 133 cases. Am J Surg Pathol. 31:329–340. 2007. View Article : Google Scholar : PubMed/NCBI
11	Terada S, Suzuki N, Tomimatsu N and Akasofu K: Vaginal schwannoma. Arch Gynecol Obstet. 251:203–206. 1992. View Article : Google Scholar : PubMed/NCBI
12	Obeidat BR, Amarin ZO and Jallad MF: Vaginal schwannoma: A case report. J Reprod Med. 52:341–342. 2007.PubMed/NCBI
13	Park JW, Hwang SO, Choi SJ, Lee BI, Park JH and Song E: Incidental diagnosis of vaginal schwannoma in a patient with thigh pain. Obstet Gynecol Sci. 57:86–88. 2014. View Article : Google Scholar : PubMed/NCBI
14	Sharma NS and Lynch MJ: Intrapelvic neurilemmoma presenting with bladder outlet obstruction. Br J Urol. 82:9171998. View Article : Google Scholar : PubMed/NCBI
15	Samarakoon L, Weerasekera A, Sanjeewa R and Kollure S: Giant presacral schwannoma presenting with constipation: A case report. J Med Case Reports. 6:2852012. View Article : Google Scholar
16	Melvin WS and Wilkinson MG: Gastric schwannoma. Clinical and pathologic considerations. Am Surg. 59:293–296. 1993.PubMed/NCBI
17	Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, et al: Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Mod Pathol. 28:187–200. 2015. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Schwannoma of the vagina - a common tumor but a rare location: A case report

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