Chemoprevention using folic acid for dysplastic lesions of the larynx

Mesolella,Massimo; Iengo,Maurizio; Testa,Domenico; Ricciardiello,Filippo; Iorio,Brigida

doi:10.3892/mco.2017.1424

November-2017 Volume 7 Issue 5

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November-2017 Volume 7 Issue 5

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Article

Chemoprevention using folic acid for dysplastic lesions of the larynx

Authors:
- Massimo Mesolella
- Maurizio Iengo
- Domenico Testa
- Filippo Ricciardiello
- Brigida Iorio
View Affiliations / Copyright

Affiliations: Department of Neuroscience, Reproductive and Odontostomatologic Science, ENT Division, University ‘Federico II’, I‑80122 Naples, Italy, Department of Anesthesiology, Surgery and Emergency Science, University ‘Luigi Vanvitelli’, I‑80122 Naples, Italy
Pages: 843-846
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Published online on: September 19, 2017

https://doi.org/10.3892/mco.2017.1424
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Abstract

Folate deficiency may be directly associated with carcinogenesis. Folate supplementation may reduce the risk of progression in a mucosa that is already genetically altered. The aim of the present study was to determine the role of folic acid in the treatment of mild and moderate laryngeal dysplasia recurring after surgery. The data obtained by laryngoscopy, measurement of serum folate levels and functional vocal assessment with the GIRBAS scale and VHI questionnaire were compared in patients who had received folic acid with a homogeneous group of patients with dysplasia who had not undergone any therapy. A total of 24 patients suffering from recurrence of mild or moderate laryngeal dysplasia (n=12, group A) were treated with 400 mg folic acid per os, once daily for 6 months. The patients in group B (n=12) received no treatment and were used as the control group. In group A, 7 (58%) patients exhibited a complete response, with clinically evident regression of leukoplakia, 3 (25%) displayed a partial decrease in the lesions with reduced volume of the area involved, whereas 2 patients exhibited no change. As regards patients in control group B, 8 (67%) exhibited no change, in 1 case there was a spontaneous regression, and in 3 (25%) there was disease progression with suspected malignant transformation, leading to repeat surgery. Therefore, folate deficiency may be considered to be a factor predisposing to precancerous lesions, and dietary folate supplementation may prevent and reduce the emergence of cancer.

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