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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2017 Volume 7 Issue 5

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Review

Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review)

  • Authors:
    • Megumi Yanokura
    • Kouji Banno
    • Yusuke Kobayashi
    • Hiroyuki Nomura
    • Shigenori Hayashi
    • Eiichiro Tominaga
    • Daisuke Aoki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160‑8582, Japan
  • Pages: 733-737
    |
    Published online on: September 20, 2017
       https://doi.org/10.3892/mco.2017.1428
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Abstract

Selective aberrant genetic effects that do not depend on abnormal DNA sequences are referred to as epigenetic abnormalities and are involved in carcinogenesis. In uterine cancer, various genes involved in apoptosis, cell cycle, DNA repair, cell proliferation and cell adhesion are abnormally methylated, resulting in gene silencing. Reversal of such epigenetic abnormalities in cancer cells is a potential strategy for cancer therapy, and studies on epigenetic abnormalities and treatment methods in uterine cancer are in progress. These include the evaluation of 5‑hydroxymethylcytosine, which is present in cancer tissues at lower levels compared with those in normal tissues, as a prognostic marker in cervical cancer; combination therapy with 5‑azacytidine and cisplatin; combination treatment focusing on tumor necrosis factor‑related apoptosis‑inducing ligand in cervical cancer; studies focusing on DNA mismatch repair in endometrial cancer; and use of a demethylating agent to reactivate tumor suppressor genes and inhibit tumor proliferation. Detection of epigenetic changes using biomarkers may be used for histological classification, evaluation of disease progression and identification of compounds that are able to modulate epigenetic changes and may be useful for uterine cancer treatment.
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1 

Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: GLOBOCAN 2012 v1.1Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 (Internet). Lyon, France: International Agency for Research on Cancer; 2014 http://globocan.iarc.frAccessed. August 10–2016

2 

Bhat S, Kabekkodu SP, Noronha A and Satyamoorthy K: Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer. Biochimie. 121:298–311. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Banzai C, Nishino K, Quan J, Yoshihara K, Sekine M, Yahata T and Tanaka K: Gynecological Cancer Registry of Niigata: Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma. Int J Clin Oncol. 19:127–132. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC and Ngan HY: p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy. Clin Cancer Res. 10:3309–3316. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Roz L, Gramegna M, Ishii H, Croce CM and Sozzi G: Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines. Proc Natl Acad Sci USA. 99:3615–3320. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Snellenberg S, Cillessen SA, Van Criekinge W, Bosch L, Meijer CJ, Snijders PJ and Steenbergen RD: Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers. Carcinogenesis. 35:2611–2618. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Wu Q, Shi H, Suo Z and Nesland JM: 5′-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas. Ultrastruct Pathol. 27:417–422. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Kitkumthorn N, Yanatatsanajit P, Kiatpongsan S, Phokaew C, Triratanachat S, Trivijitsilp P, Termrungruanglert W, Tresukosol D, Niruthisard S and Mutirangura A: Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer. BMC Cancer. 6:552006. View Article : Google Scholar : PubMed/NCBI

9 

Chujan S, Kitkumthorn N, Siriangkul S and Mutirangura A: CCNA1 promoter methylation: A potential marker for grading Papanicolaou smear cervical squamous intraepithelial lesions. Asian Pac J Cancer Prev. 15:7971–7975. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kabekkodu SP, Bhat S, Radhakrishnan R, Aithal A, Mascarenhas R, Pandey D, Rai L, Kushtagi P, Mundyat GP and Satyamoorthy K: DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. J Biol Chem. 289:10637–10649. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Aoki K and Taketo MM: Adenomatous polyposis coli (APC): A multi-functional tumor suppressor gene. J Cell Sci. 120:3327–3335. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Lin YW, Chung MT, Lai HC, De Yan M, Shih YL, Chang CC and Yu MH: Methylation analysis of SFRP genes family in cervical adenocarcinoma. J Cancer Res Clin Oncol. 135:1665–1674. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Narayan G, Arias-Pulido H, Nandula SV, Basso K, Sugirtharaj DD, Vargas H, Mansukhani M, Villella J, Meyer L, Schneider A, et al: Promoter hypermethylation of FANCF: Disruption of Fanconi Anemia-BRCA pathway in cervical cancer. Cancer Res. 64:2994–2997. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Henken FE, Wilting SM, Overmeer RM, van Rietschoten JG, Nygren AO, Errami A, Schouten JP, Meijer CJ, Snijders PJ and Steenbergen RD: Sequential gene promoter methylation during HPV-induced cervical carcinogenesis. Br J Cancer. 97:1457–1464. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Virmani AK, Muller C, Rathi A, Zoechbauer-Mueller S, Mathis M and Gazdar AF: Aberrant methylation during cervical carcinogenesis. Clin Cancer Res. 7:584–589. 2001.PubMed/NCBI

16 

Bai LX, Wang JT, Ding L, Jiang SW, Kang HJ, Gao CF, Chen X, Chen C and Zhou Q: Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization. Asian Pac J Cancer Prev. 15:9313–9317. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ivanova T, Petrenko A, Gritsko T, Vinokourova S, Eshilev E, Kobzeva V, Kisseljov F and Kisseljova N: Methylation and silencing of the retinoic acid receptor-beta 2 gene in cervical cancer. BMC Cancer. 2:42002. View Article : Google Scholar : PubMed/NCBI

18 

De Strooper LM, van Zummeren M, Steenbergen RD, Bleeker MC, Hesselink AT, Wisman GB, Snijders PJ, Heideman DA and Meijer CJ: CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer. J Clin Pathol. 67:1067–1071. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim JH, Choi YD, Lee JS, Lee JH, Nam JH and Choi C: Assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens. Gynecol Oncol. 116:99–104. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yadav SS, Prasad SB, Das M, Kumari S, Pandey LK, Singh S, Pradhan S and Narayan G: Epigenetic silencing of CXCR4 promotes loss of cell adhesion in cervical cancer. Biomed Res Int. 2014:5814032014. View Article : Google Scholar : PubMed/NCBI

21 

Overmeer RM, Henken FE, Snijders PJ, Claassen-Kramer D, Berkhof J, Helmerhorst TJ, Heideman DA, Wilting SM, Murakami Y, Ito A, et al: Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol. 215:388–397. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Bischoff J, Ignatov A, Semczuk A, Schwarzenau C, Ignatov T, Krebs T, Küster D, Przadka-Rabaniuk D, Roessner A, Costa SD and Schneider-Stock R: hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases. Clin Exp Metastasis. 29:889–900. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Guida M, Sanguedolce F, Bufo P, Di Spiezio Sardo A, Bifulco G, Nappi C and Pannone G: Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions. Eur J Gynaecol Oncol. 30:267–270. 2009.PubMed/NCBI

24 

Pallarés J, Velasco A, Eritja N, Santacana M, Dolcet X, Cuatrecasas M, Palomar-Asenjo V, Catasús L, Prat J and Matias-Guiu X: Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma. Mod Pathol. 21:691–699. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Banno K, Yanokura M, Susumu N, Kawaguchi M, Hirao N, Hirasawa A, Tsukazaki K and Aoki D: Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. Oncol Rep. 16:1189–1196. 2006.PubMed/NCBI

26 

Jo H, Kim JW, Kang GH, Park NH, Song YS, Kang SB and Lee HP: Association of promoter hypermethylation of the RASSF1A gene with prognostic parameters in endometrial cancer. Oncol Res. 16:205–209. 2006.PubMed/NCBI

27 

Lee KE: Immunohistochemical assessment of O(6)-methylguanine-DNA methyltransferase (MGMT) and Its relationship with p53 expression in endometrial cancers. J Cancer Prev. 18:351–354. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Ignatov A, Bischoff J, Ignatov T, Schwarzenau C, Krebs T, Kuester D, Costa SD, Roessner A, Semczuk A and Schneider-Stock R: APC promoter hypermethylation is an early event in endometrial tumorigenesis. Cancer Sci. 101:321–327. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Suehiro Y, Okada T, Okada T, Anno K, Okayama N, Ueno K, Hiura M, Nakamura M, Kondo T, Oga A, et al: Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation. Clin Cancer Res. 14:3354–3361. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Fiolka R, Zubor P, Janusicova V, Visnovsky J, Mendelova A, Kajo K, Lasabova Z, Plank L and Danko J: Promoter hypermethylation of the tumor-suppressor genes RASSF1A, GSTP1 and CDH1 in endometrial cancer. Oncol Rep. 30:2878–2886. 2013.PubMed/NCBI

31 

Park JH, Lee BI, Song ES, Whang SO, Lee WY and Cho SJ: Hypermethylation of E-cadherin in endometrial carcinoma. J Gynecol Oncol. 19:241–245. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Saito T, Nishimura M, Yamasaki H and Kudo R: Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma. Cancer. 97:1002–1009. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Yang HJ, Liu VW, Wang Y, Tsang PC and Ngan HY: Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. BMC Cancer. 6:2122006. View Article : Google Scholar : PubMed/NCBI

34 

Kang S, Lee JM, Jeon ES, Lee S, Kim H, Kim HS, Seo SS, Park SY, Sidransky D and Dong SM: RASSF1A hypermethylation and its inverse correlation with BRAF and/or KRAS mutations in MSI-associated endometrial carcinoma. Int J Cancer. 119:1316–1321. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Sánchez-Vega F, Gotea V, Petrykowska HM, Margolin G, Krivak TC, DeLoia JA, Bell DW and Elnitski L: Recurrent patterns of DNA methylation in the ZNF154, CASP8 and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines. Epigenetics. 8:1355–1372. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Chan QK, Khoo US, Chan KY, Ngan HY, Li SS, Chiu PM, Man LS, Ip PP, Xue WC and Cheung AN: Promoter methylation and differential expression of pi-class glutathione S-transferase in endometrial carcinoma. J Mol Diagn. 7:8–16. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Moreno-Bueno G, Fernandez-Marcos PJ, Collado M, Tendero MJ, Rodriguez-Pinilla SM, Garcia-Cao I, Hardisson D, Diaz-Meco MT, Moscat J, Serrano M and Palacios J: Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res. 67:1927–1934. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Wong OG, Huo Z, Siu MK, Zhang H, Jiang L, Wong ES and Cheung AN: Hypermethylation of SOX2 promoter in endometrial carcinogenesis. Obstet Gynecol Int. 2010:pii:6825042010. View Article : Google Scholar

39 

Muraki Y, Banno K, Yanokura M, Kobayashi Y, Kawaguchi M, Nomura H, Hirasawa A, Susumu N and Aoki D: Epigenetic DNA hypermethylation: Clinical applications in endometrial cancer (Review). Oncol Rep. 22:967–972. 2009.PubMed/NCBI

40 

Zhang QY, Yi DQ, Zhou L, Zhang DH and Zhou TM: Status and significance of CpG island methylator phenotype in endometrial cancer. Gynecol Obstet Invest. 72:183–191. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Semczuk A, Boltze C, Marzec B, Szczygielska A, Roessner A and Schneider-Stock R: p16INK4A alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas. J Cancer Res Clin Oncol. 129:589–596. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Sasaki M, Oh BR, Dharia A, Fujimoto S and Dahiya R: Inactivation of the human androgen receptor gene is associated with CpG hypermethylation in uterine endometrial cancer. Mol Carcinog. 29:59–66. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Sasaki M, Dharia A, Oh BR, Tanaka Y, Fujimoto S and Dahiya R: Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Res. 61:97–102. 2001.PubMed/NCBI

44 

Li R, Saito T, Tanaka R, Satohisa S, Adachi K, Horie M, Akashi Y and Kudo R: Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium. Cancer Lett. 219:33–40. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Dong R, Pu H, Wang Y, Yu J, Lian K and Mao C: TESTIN was commonly hypermethylated and involved in the epithelial-mesenchymal transition of endometrial cancer. APMIS. 123:394–400. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Chmelarova M, Kos S, Dvorakova E, Spacek J, Laco J, Ruszova E, Hrochova K and Palicka V: Importance of promoter methylation of GATA4 and TP53 genes in endometrioid carcinoma of endometrium. Clin Chem Lab Med. 52:1229–1234. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Catasus L, Pons C, Muñoz J, Espinosa I and Prat J: Promoter hypermethylation contributes to TIMP3 down-regulation in high stage endometrioid endometrial carcinomas. Histopathology. 62:632–641. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Boers A, Wang R, van Leeuwen RW, Klip HG, de Bock GH, Hollema H, van Criekinge W, de Meyer T, Denil S, van der Zee AGJ, et al: Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3. Clin Epigenetics. 8:292016. View Article : Google Scholar : PubMed/NCBI

49 

Zhang LY, Han CS, Li PL and Zhang XC: 5-Hydroxyme-thylcytosine expression is associated with poor survival in cervical squamous cell carcinoma. Jpn J Clin Oncol. 46:427–434. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Iyer LM, Tahiliani M, Rao A and Aravind L: Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle. 8:1698–1710. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Sood S and Srinivasan R: Alterations in gene promoter methylation and transcript expression induced by cisplatin in comparison to 5-azacytidine in HeLa and SiHa cervical cancer cell lines. Mol Cell Biochem. 404:181–191. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Chen CC, Lee KD, Pai MY, Chu PY, Hsu CC, Chiu CC, Chen LT, Chang JY, Hsiao SH and Leu YW: Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells. Cancer Cell Int. 15:982015. View Article : Google Scholar : PubMed/NCBI

53 

Narayan G, Xie D, Ishdorj G, Scotto L, Mansukhani M, Pothuri B, Wright JD, Kaufmann AM, Schneider A, Arias-Pulido H and Murty VV: Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer. Genes Chromosomes Cancer. 55:177–189. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Jascur T and Boland CR: Structure and function of the components of the human DNA mismatch repair system. Int J Cancer. 119:2030–2035. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Eto T, Zhao Y, Maruyama A, Miyashita K, Yasui A, Nakao S, Taguchi K, Shimokawa M, Oda S and Saito T: Modal variety of microsatellite instability in human endometrial carcinomas. J Cancer Res Clin Oncol. 142:353–363. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Bilbao C, Lara PC, Ramírez R, Henríquez-Hernández LA, Rodríguez G, Falcón O, León L, Perucho M, Díaz-Chico BN and Díaz-Chico JC: Microsatellite instability predicts clinical outcome in radiation-treated endometrioid endometrial cancer. Int J Radiat Oncol Biol Phys. 76:9–13. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Hampel H, Frankel W, Panescu J, Lockman J, Sotamaa K, Fix D, Comeras I, La Jeunesse J, Nakagawa H, Westman JA, et al: Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients. Cancer Res. 66:7810–7817. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Devor EJ, Schickling BM, Reyes HD, Warrier A, Lindsay B, Goodheart MJ, Santillan DA and Leslie KK: Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182. Oncol Rep. 35:2461–2465. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Zhou H, Xu X, Xun Q, Yu D, Ling J, Guo F, Yan Y, Shi J and Hu Y: microRNA-30c negatively regulates endometrial cancer cells by targeting metastasis-associated gene-1. Oncol Reports. 27:807–812. 2012.

60 

Boren T, Xiong Y, Hakam A, Wenham R, Apte S, Wei Z, Kamath S, Chen DT, Dressman H and Lancaster JM: MicroRNAs and their target messenger RNAs associated with endometrial carcinogenesis. Gynecol Oncol. 110:206–215. 2008. View Article : Google Scholar : PubMed/NCBI

61 

Lee H, Park CS, Deftereos G, Morihara J, Stern JE, Hawes SE, Swisher E, Kiviat NB and Feng Q: MicroRNA expression in ovarian carcinoma and its correlation with clinicopathological features. World J Surg Oncol. 10:1742012. View Article : Google Scholar : PubMed/NCBI

62 

Li S, Yang C, Zhai L, Zhang W, Yu J, Gu F, Lang R, Fan Y, Gong M, Zhang X and Fu L: Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the breast. Breast Cancer Res Treat. 136:77–87. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, et al: Relation between microRNA expression and progression and prognosis of gastric cancer: A microRNA expression analysis. Lancet Oncol. 11:136–146. 2010. View Article : Google Scholar : PubMed/NCBI

64 

Duenas-Gonzalez A, Medina-Franco JL, Chavez-Blanco A, Dominguez-Gomez G and Fernández-de Gortari E: Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers. Expert Opin Pharmacother. 17:323–338. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Song Y and Zhang C: Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression. Cancer Chemother Pharmacol. 63:605–613. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D and Inazawa J: miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res. 71:6450–6462. 2011. View Article : Google Scholar : PubMed/NCBI

67 

Zhao X, Zhu D, Lu C, Yan D, Li L and Chen Z: MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1. Oncol Lett. 11:1207–1212. 2016.PubMed/NCBI

68 

Ren J, Zhang J, Cai H, Li Y, Zhang Y, Zhang X, Zhao D, Li Z, Ma H, Wang J, et al: HDAC as a therapeutic target for treatment of endometrial cancers. Curr Pharm Des. 20:1847–1856. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Yi TZ, Li J, Han X, Guo J, Qu Q, Guo L, Sun HD and Tan WH: DNMT inhibitors and HDAC inhibitors regulate E-cadherin and bcl-2 expression in endometrial carcinoma in vitro and in vivo. Chemotherapy. 58:19–29. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yanokura M, Banno K, Kobayashi Y, Nomura H, Hayashi S, Tominaga E and Aoki D: Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review). Mol Clin Oncol 7: 733-737, 2017.
APA
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., & Aoki, D. (2017). Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review). Molecular and Clinical Oncology, 7, 733-737. https://doi.org/10.3892/mco.2017.1428
MLA
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., Aoki, D."Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review)". Molecular and Clinical Oncology 7.5 (2017): 733-737.
Chicago
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., Aoki, D."Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review)". Molecular and Clinical Oncology 7, no. 5 (2017): 733-737. https://doi.org/10.3892/mco.2017.1428
Copy and paste a formatted citation
x
Spandidos Publications style
Yanokura M, Banno K, Kobayashi Y, Nomura H, Hayashi S, Tominaga E and Aoki D: Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review). Mol Clin Oncol 7: 733-737, 2017.
APA
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., & Aoki, D. (2017). Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review). Molecular and Clinical Oncology, 7, 733-737. https://doi.org/10.3892/mco.2017.1428
MLA
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., Aoki, D."Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review)". Molecular and Clinical Oncology 7.5 (2017): 733-737.
Chicago
Yanokura, M., Banno, K., Kobayashi, Y., Nomura , H., Hayashi, S., Tominaga, E., Aoki, D."Recent findings on epigenetic gene abnormalities involved in uterine cancer (Review)". Molecular and Clinical Oncology 7, no. 5 (2017): 733-737. https://doi.org/10.3892/mco.2017.1428
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