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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Review

Triple‑negative breast cancer and its association with obesity (Review)

  • Authors:
    • Heng Sun
    • Jing Zou
    • Ling Chen
    • Xuyu Zu
    • Gebo Wen
    • Jing Zhong
  • View Affiliations / Copyright

    Affiliations: Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China, Department of Neurological Medicine, Hunan Institute of Gerontology, Hunan Geriatric Hospital, Changsha, Hunan 410016, P.R. China
  • Pages: 935-942
    |
    Published online on: September 29, 2017
       https://doi.org/10.3892/mco.2017.1429
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Abstract

Triple‑negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of the estrogen and progesterone receptor and does not overexpress human epidermal growth factor 2 receptor protein. TNBC is associated with special characteristics, including aggressiveness, poor prognosis and poor response to treatment, and has been attracting increasing attention worldwide. Obesity is a well‑documented factor exerting a significant effect on the development of breast cancer, including TNBC. The purpose of the present review was to focus on the association between obesity and TNBC and provide a summary of novel research findings. The aim was to highlight the association between TNBC and obesity and provide an overview of novel outlooks on clinical issues, biological rationale, novel targeted therapies and prognosis, in order to draw attention to the significance of weight management, primary prevention, early diagnosis and treatment of this intractable disease.
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Copy and paste a formatted citation
Spandidos Publications style
Sun H, Zou J, Chen L, Zu X, Wen G and Zhong J: Triple‑negative breast cancer and its association with obesity (Review). Mol Clin Oncol 7: 935-942, 2017.
APA
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., & Zhong, J. (2017). Triple‑negative breast cancer and its association with obesity (Review). Molecular and Clinical Oncology, 7, 935-942. https://doi.org/10.3892/mco.2017.1429
MLA
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., Zhong, J."Triple‑negative breast cancer and its association with obesity (Review)". Molecular and Clinical Oncology 7.6 (2017): 935-942.
Chicago
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., Zhong, J."Triple‑negative breast cancer and its association with obesity (Review)". Molecular and Clinical Oncology 7, no. 6 (2017): 935-942. https://doi.org/10.3892/mco.2017.1429
Copy and paste a formatted citation
x
Spandidos Publications style
Sun H, Zou J, Chen L, Zu X, Wen G and Zhong J: Triple‑negative breast cancer and its association with obesity (Review). Mol Clin Oncol 7: 935-942, 2017.
APA
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., & Zhong, J. (2017). Triple‑negative breast cancer and its association with obesity (Review). Molecular and Clinical Oncology, 7, 935-942. https://doi.org/10.3892/mco.2017.1429
MLA
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., Zhong, J."Triple‑negative breast cancer and its association with obesity (Review)". Molecular and Clinical Oncology 7.6 (2017): 935-942.
Chicago
Sun, H., Zou, J., Chen, L., Zu, X., Wen, G., Zhong, J."Triple‑negative breast cancer and its association with obesity (Review)". Molecular and Clinical Oncology 7, no. 6 (2017): 935-942. https://doi.org/10.3892/mco.2017.1429
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