Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature

Yokomizo,Ryo; Yamada,Kyosuke; Iida,Yasushi; Kiyokawa,Takako; Ueda,Kazu; Saito,Motoaki; Yanaihara,Nozomu; Nakamura,Mayo; Okamoto,Aikou

doi:10.3892/mco.2017.1437

December-2017 Volume 7 Issue 6

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December-2017 Volume 7 Issue 6

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Article

Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature

Authors:
- Ryo Yokomizo
- Kyosuke Yamada
- Yasushi Iida
- Takako Kiyokawa
- Kazu Ueda
- Motoaki Saito
- Nozomu Yanaihara
- Mayo Nakamura
- Aikou Okamoto
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo 105‑8461, Japan, Department of Pathology, The Jikei University School of Medicine, Tokyo 105‑8461, Japan
Pages: 1008-1012
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Published online on: October 3, 2017

https://doi.org/10.3892/mco.2017.1437
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Abstract

Dedifferentiated endometrial carcinoma, which is defined microscopically as the co‑existence of undifferentiated carcinoma and grade 1 or 2 endometrioid adenocarcinoma, is an aggressive type of cancer regardless of the percentage of undifferentiated components. It is reported that undifferentiated carcinoma comprises 9% of endometrial carcinoma. The percentage of dedifferentiated endometrial carcinoma has been hypothesized to be 40% of undifferentiated carcinoma. A precise pathological diagnosis is essential for defining the appropriate therapeutic approach and prognosis. Furthermore, since there is an association between dedifferentiated endometrial carcinoma and Lynch syndrome, it is important to identify the patient's genetic background. The current case report presents three cases of dedifferentiated endometrial carcinoma treated in our hospital. In immunohistochemical staining for DNA mismatch‑repair (MMR) proteins in dedifferentiated endometrial carcinoma, the components of undifferentiated carcinoma demonstrated a loss of MMR protein expression, and it is suspected that there may be a germline mutation in these cases. Therefore, Lynch syndrome should be suspected and the appropriate genetic approaches in cases of dedifferentiated endometrial carcinoma should be considered.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Dedifferentiated endometrial carcinoma: A report of three cases and review of the literature

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