Bilateral and multiple mixed epithelial and stromal tumors of the kidney: A case report

Minoda,Ryo; Takagi,Toshio; Toda,Naohiro; Itagaki,Hiroko; Kondo,Tsunenori; Ishida,Hideki; Nagashima,Yoji; Tanabe,Kazunari

doi:10.3892/mco.2017.1444

December-2017 Volume 7 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2017 Volume 7 Issue 6

Full Size Image

Case Report Open Access

Bilateral and multiple mixed epithelial and stromal tumors of the kidney: A case report

Authors:
- Ryo Minoda
- Toshio Takagi
- Naohiro Toda
- Hiroko Itagaki
- Tsunenori Kondo
- Hideki Ishida
- Yoji Nagashima
- Kazunari Tanabe
View Affiliations / Copyright

Affiliations: Department of Urology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan, Department of Surgical Pathology, Tokyo Women's Medical University, Tokyo 162‑8666, Japan

Copyright: © Minoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1005-1007
|
Published online on: October 6, 2017

https://doi.org/10.3892/mco.2017.1444
Expand metrics +

Abstract

Mixed epithelial and stromal tumor (MEST) of the kidney is a benign tumor occurring predominantly in older women. Histologically, MEST comprises tubuloglandular and cystic structures in an ovarian‑like stroma. Bilateral and multiple cases are rare. We herein present a case of bilateral and multiple MEST in a 43‑year‑old woman. The patient presented with gross hematuria and was referred to a primary care physician. A computed tomography scan revealed 5 tumors in the right and 2 in the left kidney. Renal cell carcinoma was suspected, and left partial nephrectomy followed by right radical nephrectomy was planned. After the left partial nephrectomy, the histopathological diagnosis was MEST, which was consistent with the results obtained following needle biopsy. Therefore, the contralateral tumor was also suspected to be MEST, and needle biopsy was performed. The histopathological diagnosis was identical and the right kidney was spared. The patient is currently periodically monitored. As MEST is a benign tumor, preoperative diagnosis is crucial for avoiding overtreatment.

View Figures

View References

1	Lane BR, Campbell SC, Remer EM, Fergany AF, Williams SB, Novick AC, Weight CJ, Magi-Galluzzi C and Zhou M: Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: Clinical, radiographic, and pathologic characteristics. Urology. 71:1142–1148. 2008. View Article : Google Scholar : PubMed/NCBI
2	Eble JN, Sauter G, Epstein JI and Sesterhenn IA: World Health Organization Classification of TumorsPathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press; Lyon: 2004
3	Montironi R, Mazzucchelli R, Lopez-Beltran A, Martignoni G, Cheng L, Montorsi F and Scarpelli M: Cystic nephroma and mixed epithelial and stromal tumour of the kidney: Opposite ends of the spectrum of the same entity? Eur Urol. 54:1237–1246. 2008. View Article : Google Scholar : PubMed/NCBI
4	Moslemi MK: Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: An update. Urol J. 7:141–147. 2010.PubMed/NCBI
5	Sangoi AR and Higgins JP: Bilateral mixed epithelial stromal tumor in an end-stage renal disease patient: The first case report. Hum Pathol. 39:142–146. 2008. View Article : Google Scholar : PubMed/NCBI
6	Terao H, Makiyama K, Yanagisawa M, Miyake M, Sano F, Kita K, Murakami T, Nakaigawa N, Ogawa T, Uemura H, et al: Mixed epithelial and stromal tumor of kidney: A case report. Hinyokika Kiyo. 55:495–498. 2009.(In Japanese). PubMed/NCBI
7	Truong LD, Williams R, Ngo T, Cawood C, Chevez-Barrios P, Awalt HL, Brown RW, Younes M and Ro JY: Adult mesoblastic nephroma: Expansion of the morphologic spectrum and review of literature. Am J Surg Pathol. 22:827–839. 1998. View Article : Google Scholar : PubMed/NCBI
8	Suzuki T, Hiragata S, Hosaka K, Oyama T, Kuroda N, Hes O and Michal M: Malignant mixed epithelial and stromal tumor of the kidney: Report of the first male case. Int J Urol. 20:448–450. 2013. View Article : Google Scholar : PubMed/NCBI
9	Adsay NV, Eble J, Srigley JR, Jones EC and Grignon DJ: Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol. 24:958–970. 2000. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bilateral and multiple mixed epithelial and stromal tumors of the kidney: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Related Articles