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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report

Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature

  • Authors:
    • Caspar Franck
    • Ali Canbay
    • Peter Malfertheiner
    • Marino Venerito
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto‑von‑Guericke University Hospital, D-39120 Magdeburg, Germany
  • Pages: 1069-1072
    |
    Published online on: October 6, 2017
       https://doi.org/10.3892/mco.2017.1445
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Abstract

Perioperative platinum/fluoropyrimidine-based chemotherapy is the therapeutic standard for oesophagogastric cancer (OAC) patients with locoregional disease. The preoperative condition directly affects postoperative prognosis; thus, particularly for elderly patients, a perioperative regimen with a favourable side effect profile is highly desirable. In the palliative setting, the combination of cisplatin and S-1 (Cis/S-1) was found to be as effective as cisplatin/5-fluorouracil, but with a more favourable side effect profile. However, no data on this combination have been reported in the perioperative setting in Caucasian patients. To the best of our knowledge, this is the first report on the treatment outcome of two elderly Caucasian OAC patients with locoregional disease receiving two neoadjuvant 4-week cycles of intravenous Cis/S-1. Both patients tolerated the doublet therapy well. No treatment delay or dose reduction was required. In both cases, preoperative staging revealed a clear response and complete surgical resection could be performed without any complications.
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Spandidos Publications style
Franck C, Canbay A, Malfertheiner P and Venerito M: Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature. Mol Clin Oncol 7: 1069-1072, 2017.
APA
Franck, C., Canbay, A., Malfertheiner, P., & Venerito, M. (2017). Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature. Molecular and Clinical Oncology, 7, 1069-1072. https://doi.org/10.3892/mco.2017.1445
MLA
Franck, C., Canbay, A., Malfertheiner, P., Venerito, M."Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature". Molecular and Clinical Oncology 7.6 (2017): 1069-1072.
Chicago
Franck, C., Canbay, A., Malfertheiner, P., Venerito, M."Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature". Molecular and Clinical Oncology 7, no. 6 (2017): 1069-1072. https://doi.org/10.3892/mco.2017.1445
Copy and paste a formatted citation
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Spandidos Publications style
Franck C, Canbay A, Malfertheiner P and Venerito M: Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature. Mol Clin Oncol 7: 1069-1072, 2017.
APA
Franck, C., Canbay, A., Malfertheiner, P., & Venerito, M. (2017). Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature. Molecular and Clinical Oncology, 7, 1069-1072. https://doi.org/10.3892/mco.2017.1445
MLA
Franck, C., Canbay, A., Malfertheiner, P., Venerito, M."Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature". Molecular and Clinical Oncology 7.6 (2017): 1069-1072.
Chicago
Franck, C., Canbay, A., Malfertheiner, P., Venerito, M."Neoadjuvant treatment with cisplatin and S-1 in elderly patients with oesophagogastric adenocarcinoma and locoregional disease: Two case reports and review of the literature". Molecular and Clinical Oncology 7, no. 6 (2017): 1069-1072. https://doi.org/10.3892/mco.2017.1445
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