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Article

Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study

  • Authors:
    • Leonora Wijnandina de Boo
    • Annelie Johanna Elisabeth Vulink
    • Monique Elisabeth Martina Maria Bos
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Reinier de Graaf Hospital, 2625AD Delft, The Netherlands, Division of Medical Oncology, Reinier de Graaf Hospital, 2625AD Delft, The Netherlands, Department of Medical Oncology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
  • Pages: 1130-1134
    |
    Published online on: October 18, 2017
       https://doi.org/10.3892/mco.2017.1457
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Abstract

Metronomic oral cyclophosphamide has gained increasing interest in recent years as a promising maintenance therapy in advanced, platinum-sensitive, high-grade serous ovarian cancer (HGSOC). Metronomic treatment with cyclophosphamide refers to the frequent, usually daily, administration of a low (oral) dose of cyclophosphamide with no prolonged drug-free breaks. Main advantages of this treatment are the effective reduction of tumour activity, oral administration in an outpatient setting, low cost and the low toxicity profile. Metronomic oral cyclophosphamide can benefit patients suffering from types of cancer known to be sensitive to alkylating agents, such as platinum-sensitive HGSOC. In recent years, several publications have underlined the advantage of this regimen and possible explanations were explored. We here present a patient with multiple recurrences of metastasized HGSOC, platinum-sensitive, with an on-going complete response to monotherapy with oral cyclophosphamide. This observation supports that patients with relapsing HGSOC who responded to platinum-based chemotherapy and cannot continue platinum-based chemotherapy because of toxicity, can be offered a course of metronomic cyclophosphamide. This case may serve as a reminder that old drugs can be used successfully even in the age of new upcoming therapy such as anti-angiogenic agents (VEGF inhibitors) and poly-ADP-ribose polymerase (PARP) inhibitors.
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Copy and paste a formatted citation
Spandidos Publications style
de Boo LW, Vulink AJ and Bos ME: Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study. Mol Clin Oncol 7: 1130-1134, 2017.
APA
de Boo, L.W., Vulink, A.J., & Bos, M.E. (2017). Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study. Molecular and Clinical Oncology, 7, 1130-1134. https://doi.org/10.3892/mco.2017.1457
MLA
de Boo, L. W., Vulink, A. J., Bos, M. E."Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study". Molecular and Clinical Oncology 7.6 (2017): 1130-1134.
Chicago
de Boo, L. W., Vulink, A. J., Bos, M. E."Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study". Molecular and Clinical Oncology 7, no. 6 (2017): 1130-1134. https://doi.org/10.3892/mco.2017.1457
Copy and paste a formatted citation
x
Spandidos Publications style
de Boo LW, Vulink AJ and Bos ME: Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study. Mol Clin Oncol 7: 1130-1134, 2017.
APA
de Boo, L.W., Vulink, A.J., & Bos, M.E. (2017). Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study. Molecular and Clinical Oncology, 7, 1130-1134. https://doi.org/10.3892/mco.2017.1457
MLA
de Boo, L. W., Vulink, A. J., Bos, M. E."Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study". Molecular and Clinical Oncology 7.6 (2017): 1130-1134.
Chicago
de Boo, L. W., Vulink, A. J., Bos, M. E."Metronomic cyclophosphamide‑induced long‑term remission after recurrent high‑grade serous ovarian cancer: A case study". Molecular and Clinical Oncology 7, no. 6 (2017): 1130-1134. https://doi.org/10.3892/mco.2017.1457
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