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Article

Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China

  • Authors:
    • Rong‑Miao Zhou
    • Yan Li
    • Na Wang
    • Xi Huang
    • Shi‑Ru Cao
  • View Affiliations / Copyright

    Affiliations: Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 170-174
    |
    Published online on: October 27, 2017
       https://doi.org/10.3892/mco.2017.1475
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Abstract

Recent genome‑wide association studies identified susceptibility loci for esophageal squamous cell carcinoma (ESCC), the most common histological type of esophageal cancer, in the phospholipase C ε‑1 gene (PLCE1). The aim of the present study was to investigate whether polymorphisms of PLCE1 were associated with the prognosis of ESCC patients in a high‑incidence region of northern China. The PLCE1 rs2274223 A/G and rs11599672T/G single‑nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction‑ligase detection reaction method in 207 ESCC patients with survival information. The mean age ± standard deviation of the 207 ESCC patients was 60.3±7.9 years. Sex, age, smoking status and family history of upper gastrointestinal cancer were not found to be associated with the survival time of ESCC patients. The mean survival time of rs2274223 SNP A/A, A/G and G/G genotype carriers were 42.9, 43.4 and 46.3 months, respectively; for rs11599672 SNP T/T, T/G and G/G genotype carriers the survival time were 42.8, 43.8 and 42.7 months, respectively. There was no significant difference in survival time among the ESCC patients with different genotypes of rs2274223 and rs11599672 SNPs. In conclusion, PLCE1 rs227423 and rs11599672 SNPs cannot be used as predictive markers for the survival of ESCC patients from a high‑incidence region of northern China.
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1 

He Y, Wu Y, Song G, Li Y, Liang D, Jin J, Wen D and Shan B: Incidence and mortality rate of esophageal cancer has decreased during past 40 years in Hebei Province, China. Chin J Cancer Res. 27:562–571. 2015.PubMed/NCBI

2 

Manolio TA: Genomewide association studies and assessment of the risk of disease. N Engl J Med. 363:166–176. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, et al: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet. 42:759–763. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, et al: A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet. 42:764–767. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, et al: Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 43:679–684. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Duan F, Xie W, Cui L, Wang P, Song C, Qu H, Wang K, Zhang J and Dai L: Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population. Cancer Epidemiol. 37:647–652. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Umar M, Upadhyay R, Kumar S, Ghoshal UC and Mittal B: Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population. Tumour Biol. 35:11667–11676. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Cui XB, Chen YZ, Pang XL, Liu W, Hu JM, Li SG, Yang L, Zhang WJ, Liu CX, Cao YW, et al: Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. Gene. 530:315–322. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gu H, Ding G, Zhang W, Liu C, Chen Y, Chen S and Jiang P: Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population. Mol Biol Rep. 39:9105–9111. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Hu H, Yang J, Sun Y, Yang Y, Qian J, Jin L, Wang M, Bi R, Zhang R, Zhu M, et al: Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): A case-control study in eastern Chinese populations. Ann Surg Oncol. 19:2403–2410. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Palmer AJ, Lochhead P, Hold GL, Rabkin CS, Chow WH, Lissowska J, Vaughan TL, Berry S, Gammon M, Risch H and El-Omar EM: Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations. Eur J Cancer Prev. 21:541–544. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Jia X, Liu P, Zhang M, Feng T, Tang H, Tang Z, Zhao H and Jin T: Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. Int J Clin Exp Med. 8:19381–19387. 2015.PubMed/NCBI

13 

Rhee SG: Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem. 70:281–312. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Smrcka AV, Brown JH and Holz GG: Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cell Signal. 24:1333–1343. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV and Brown JH: Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proc Natl Acad Sci USA. 104:pp. 15543–15548. 2007; View Article : Google Scholar : PubMed/NCBI

16 

Wang M, Zhang R, He J, Qiu L, Li J, Wang Y, Sun M, Yang Y, Wang J, Yang J, et al: Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One. 7:e319322012. View Article : Google Scholar : PubMed/NCBI

17 

Chen J, Wang W, Zhang T, Ji J, Qian Q, Lu L, Fu H, Jin W and Cui D: Differential expression of phospholipase C epsilon 1 is associated with chronic atrophic gastritis and gastric cancer. PLoS One. 7:e475632012. View Article : Google Scholar : PubMed/NCBI

18 

Sorli SC, Bunney TD, Sugden PH, Paterson HF and Katan M: Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants. Oncogene. 24:90–100. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Wang X, Zbou C, Qiu G, Fan J, Tang H and Peng Z: Screening of new tumor suppressor genes in sporadic colorectal cancer patients. Hepatogastroenterology. 55:2039–2044. 2008.PubMed/NCBI

20 

Ling Y, Chunli L, Xiaohou W and Qiaoling Z: Involvement of the PLCε/PKCα pathway in human BIU-87 bladder cancer cell proliferation. Cell Biol Int. 35:1031–1036. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Yan L, Zhao Y, Ou L, Wu X and Luo C: Knockdown of phospholipase C-epsilon by short-hairpin RNA-mediated gene silencing induces apoptosis in human bladder cancer cell lines. Cancer Biother Radiopharm. 28:233–239. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Du HF, Ou LP, Yang X, Song XD, Fan YR, Tan B, Luo CL and Wu XH: A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells. Cell Signal. 26:580–593. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Cui XB, Li S, Li TT, Peng H, Jin TT, Zhang SM, Liu CX, Yang L, Shen YY, Li SG, et al: Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget. 7:1777–1795. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Li WQ, Hu N, Burton VH, Yang HH, Su H, Conway CM, Wang L, Wang C, Ding T, Xu Y, et al: PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 23:1579–1588. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zhou RM, Li Y, Wang N, Liu BC, Chen ZF and Zuo LF: PLC-ε1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers. Arch Med Res. 43:578–584. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Miller SA, Dykes DD and Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16:12151988. View Article : Google Scholar : PubMed/NCBI

27 

Plum PS, Bollschweiler E, Hölscher AH and Warnecke-Eberz U: Novel diagnostic and prognostic biomarkers in esophageal cancer. Expert Opin Med Diagn. 7:557–571. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Wang LD, Bi X, Song X, Pohl NM, Cheng Y, Zhou Y, Shears S, Ansong E, Xing M, Wang S, et al: A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis. Mol Carcinog. 52 Suppl 1:E80–E86. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhao L, Wei ZB, Yang CQ, Chen JJ, Li D, Ji AF and Ma L: Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells. Asian Pac J Cancer Prev. 15:5437–5442. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Chen YZ, Cui XB, Hu JM, Zhang WJ, Li SG, Yang L, Shen XH, Liu CX, Pan QF, Yu SY, et al: Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: Implications in cancer metastasis and aggressiveness. APMIS. 121:908–918. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Tyutyunnykova A, Telegeev G and Dubrovska A: The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression. J Cancer. 8:716–729. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Ma H, Wang LE, Liu Z, Sturgis EM and Wei Q: Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. BMC Cancer. 11:2582011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou RM, Li Y, Wang N, Huang X and Cao SR: Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China. Mol Clin Oncol 8: 170-174, 2018.
APA
Zhou, R., Li, Y., Wang, N., Huang, X., & Cao, S. (2018). Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China. Molecular and Clinical Oncology, 8, 170-174. https://doi.org/10.3892/mco.2017.1475
MLA
Zhou, R., Li, Y., Wang, N., Huang, X., Cao, S."Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China". Molecular and Clinical Oncology 8.1 (2018): 170-174.
Chicago
Zhou, R., Li, Y., Wang, N., Huang, X., Cao, S."Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China". Molecular and Clinical Oncology 8, no. 1 (2018): 170-174. https://doi.org/10.3892/mco.2017.1475
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou RM, Li Y, Wang N, Huang X and Cao SR: Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China. Mol Clin Oncol 8: 170-174, 2018.
APA
Zhou, R., Li, Y., Wang, N., Huang, X., & Cao, S. (2018). Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China. Molecular and Clinical Oncology, 8, 170-174. https://doi.org/10.3892/mco.2017.1475
MLA
Zhou, R., Li, Y., Wang, N., Huang, X., Cao, S."Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China". Molecular and Clinical Oncology 8.1 (2018): 170-174.
Chicago
Zhou, R., Li, Y., Wang, N., Huang, X., Cao, S."Phospholipase C ε‑1 gene polymorphisms and prognosis of esophageal cancer patients from a high‑incidence region in northern China". Molecular and Clinical Oncology 8, no. 1 (2018): 170-174. https://doi.org/10.3892/mco.2017.1475
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