Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
January-2018 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2018 Volume 8 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Role of P‑selectin in thromboembolic events in patients with cancer

  • Authors:
    • Lúcio Flávio Barbour Fernandes
    • José Humberto T.G. Fregnani
    • Célia Maria Cássaro Strunz
    • Adriana de Andrade Ramos Nogueira
    • Adhemar Longatto‑Filho
  • View Affiliations / Copyright

    Affiliations: Institute of Education and Research and Molecular Oncology Research Center (CPOM), Pio XII Foundation, Barretos Cancer Hospital, Barretos, São Paulo 14784‑400, Brazil, Heart Institute (InCor), Faculty of Medicine, University of São Paulo, São Paulo 1246‑903, Brazil
  • Pages: 188-196
    |
    Published online on: November 2, 2017
       https://doi.org/10.3892/mco.2017.1482
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The objective of the present study was to evaluate the role of P‑selectin in patients with cancer with suspected thromboembolic events (TEEs). Patients with cancer have a four times greater risk of developing TEEs. P‑selectin is a glycoprotein that has the function of facilitating the interaction (adhesion) of leukocytes with the endothelium, or with platelets. There is a well‑defined relationship between P‑selectin and thrombosis; however, it is likely that the cut‑off value of P‑selectin for patients with cancer should be considered differently from that of the general population. In the present report, a prospective cross‑sectional study was performed with patients of the Cancer Hospital of Barretos who were suspected of having TEEs. Among the 178 study participants, 167 (93.82%) were suspected of having deep vein thrombosis, while 59 of them (35.33%) were confirmed as such; and 11 (6.18%) were suspected of having pulmonary thromboembolism, while 3 of them were confirmed as such (27.69%). The mean results obtained were: P‑selectin, 25.37 ng/ml; and D‑dimer, 2,181.22 ng/ml. The P‑selectin levels averaged 33.60 ng/ml with the confirmed TEE group compared with 20.40 ng/ml with the unconfirmed TEE group, with a standard deviation of 23.35 compared with 6.92 (P<0.001); and the level of D‑dimer was 4,615.38 ng/ml compared with 977.52 ng/ml, with a standard deviation of 6,460.54 compared with 2,145.50 (P<0.001). Multiple logistic regression adjusted for distant metastases and the Eastern Cooperative Oncology Group (ECOG) score (2,3 and 4) were constructed. The cut‑off value of P‑selectin for patients with cancer was identified to be different from that reported in the literature for the general population, and the models using D‑dimer and P‑selectin therefore have been demonstrated to be a potentially useful tool to be used in a panel of tests to predict TEEs, either independently or in a prediction score.
View Figures
View References

1 

Huth EJ and Murray TJ: Medicine in Quotations: Views of Health and Disease Through the Ages. American College of Physicians, Philadelphia. 2006.

2 

Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM and Melton LJ III: Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch Intern Med. 158:585–593. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Gillum RF: Pulmonary embolism and thrombophlebitis in the United States, 1970–1985. Am Heart J. 114:1262–1264. 1987. View Article : Google Scholar : PubMed/NCBI

4 

Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, Forcier A and Dalen JE: A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: The Worcester DVT Study. Arch Intern Med. 151:933–938. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Nordström M, Lindblad B, Bergqvist D and Kjellström T: A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med. 232:155–160. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Kierkegaard A: Incidence of acute deep vein thrombosis in two districts. A phlebographic study. Acta Chir Scand. 146:267–279. 1980.PubMed/NCBI

7 

Coon WW, Willis PW III and Keller JB: Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 48:839–846. 1973. View Article : Google Scholar : PubMed/NCBI

8 

Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH and Nielsen GL: The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med. 338:1169–1173. 1998. View Article : Google Scholar : PubMed/NCBI

9 

White RH: The epidemiology of venous thromboembolism. Circulation. 107(23 Suppl 1): I4–I8. 2003.PubMed/NCBI

10 

Moser KM, Fedullo PF, LitteJohn JK and Crawford R: Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis. JAMA. 271:223–235. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Meignan M, Rosso J, Gauthier H, Brunengo F, Claudel S, Sagnard L, d'Azemar P, Simonneau G and Charbonnier B: Systematic lung scans reveal a high frequency of silent pulmonary embolism in patients with proximal deep venous thrombosis. Arch Intern Med. 160:159–164. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Hirsh J and Hoak J: Management of deep vein thrombosis and pulmonary embolism. A statement for healthcare professionals. Council on Thrombosis (in consultation with the Council on Cardiovascular Radiology), American Heart Association. Circulation. 93:2212–2245. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Prandoni P, Lensing AW, Cogo A, Cuppini S, Villalta S, Carta M, Cattelan AM, Polistena P, Bernardi E and Prins MH: The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 125:1–7. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Cushman M, Tsai A, Heckbert S, White R, Rosamund W and Enright P: Incidence rates, case fatality and recurrence rates of deep vein thrombosis and pulmonary embolus: The Longitudinal Investigation of Thromboembolism Etiology (LITE). Thromb Haemost. 86:2001.

15 

Kyrle PA and Eichinger S: Deep vein thrombosis. Lancet. 365:1163–1174. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Goldhaber SZ, Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Willett WC and Hennekens CH: A prospective study of risk factors for pulmonary embolism in women. JAMA. 277:642–645. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Salzman E and Hirsh J: The epidemiology, pathogenesis and natural history of venous thrombosisHemostasis and thrombosis, basic principles and clinical practice. 3rd. Philadelphia, PA: Lippincott; pp. 1–1296. 1994

18 

Darvall KA, Sam RC, Silverman SH, Bradbury AW and Adam DJ: Obesity and thrombosis. Eur J Vasc Endovasc Surg. 33:223–233. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Cushman M, Tsai AW, White RH, Heckbert SR, Rosamond WD, Enright P and Folsom AR: Deep vein thrombosis and pulmonary embolism in two cohorts: The longitudinal investigation of thromboembolism etiology. Am J Med. 117:19–25. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Volschan A, Caramelli B, Gottschall CA, Blacher C, Casagrande EL, Ede A Lucio, Manente ER, Mesquita ET, Bodanese LC and Rocha MS: Guidelines for pulmonary embolism. Arq Bras Cardiol. 83(Suppl 1): S1–S8. 2004.(In Portuguese).

21 

Ginsberg JS, Wells PS, Kearon C, Anderson D, Crowther M, Weitz JI, Bormanis J, Brill-Edwards P, Turpie AG, MacKinnon B, et al: Sensitivity and specificity of a rapid whole-blood assay for D-dimer in the diagnosis of pulmonary embolism. Ann Intern Med. 129:1006–1011. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Lowe GD, Rumley A, McMahon AD, Ford I, O'Reilly DS and Packard CJ; West of Scotland Coronary Prevention Study Group, : Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arterioscler Thromb Vasc Biol. 24:1529–1534. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Zipes DP, Libby P and Bonow RO: Braunwald: Tratado de doenças cardiovasculares. Elsevier; São Paulo: 2006, (In Portuguese).

24 

Venturinelli ML, Hovnan A, Ade M Soeiro, Nicolau JC, Ramires JA, D'Amico EA and Serrano CV Jr: Platelet activation in different clinical forms of the coronary artery disease (role of P-selectin and others platelet markers in stable and unstable angina). Arq Bras Cardiol. 87:446–450. 2006.(In English, Portuguese). View Article : Google Scholar : PubMed/NCBI

25 

Geng JG, Chen M and Chou KC: P-selectin cell adhesion molecule in inflammation, thrombosis, cancer growth and metastasis. Curr Med Chem. 11:2153–2160. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Francischetti I, Moreno JB, Scholz M and Yoshida WB: Leukocytes and the inflammatory response in ischemia-reperfusion injury. Rev Bras Cir Cardiovasc. 25:575–584. 2010.(In English, Portuguese). View Article : Google Scholar : PubMed/NCBI

27 

Kansas GS: Selectins and their ligands: Current concepts and controversies. Blood. 88:3259–3287. 1996.PubMed/NCBI

28 

Kozlowski EO, Pavao MS and Borsig L: Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin. J Thromb Haemost. 9:1807–1815. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Myers DD, Hawley AE, Farris DM, Wrobleski SK, Thanaporn P, Schaub RG, Wagner DD, Kumar A and Wakefield TW: P-selectin and leukocyte microparticles are associated with venous thrombogenesis. J Vasc Surg. 38:1075–1089. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Ay C, Simanek R, Vormittag R, Dunkler D, Alguel G, Koder S, Kornek G, Marosi C, Wagner O, Zielinski C and Pabinger I: High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: Results from the Vienna Cancer and Thrombosis Study (CATS). Blood. 112:2703–2708. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ay C, Dunkler D, Marosi C, Chiriac AL, Vormittag R, Simanek R, Quehenberger P, Zielinski C and Pabinger I: Prediction of venous thromboembolism in cancer patients. Blood. 116:5377–5382. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Hanna DL, White RH and Wun T: Biomolecular markers of cancer-associated thromboembolism. Crit Rev Oncol Hematol. 88:19–29. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Agarwal V, Phung OJ, Tongbram V, Bhardwaj A and Coleman CI: Statin use and the prevention of venous thromboembolism: A meta-analysis. Int J Clin Pract. 64:1375–1383. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Hathaway W and Goodnight S: Disorders of Hemostasis and Thrombosis: A Clinical Guide. 2nd. McGraw-Hill, Health Professions Division; 1993

35 

Ramacciotti E, Blackburn S, Hawley AE, Vandy F, Ballard-Lipka N, Stabler C, Baker N, Guire KE, Rectenwald JE, Henke PK, et al: Evaluation of soluble P-selectin as a marker for the diagnosis of deep venous thrombosis. Clin Appl Thromb Hemost. 17:425–431. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

37 

Anjos LA: Body mass index (body mass.body height-2) as indicator of nutritional status in adults: review of the literature. Rev Saude Publica. 26:431–436. 1992.(In Portuguese). View Article : Google Scholar : PubMed/NCBI

38 

Godoy-Matos A, Oliveira J, Guedes EP, Carraro L, Lopes AC, Mancini MC, Suplicy HL, Brito CLS, Bystronski DP, Mombach KD, et al: Diretrizes brasileiras de obesidade 2009 2010 1. Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica (ABESO). 2009.(In Portuguese).

39 

Sposito AC, Caramelli B, Fonseca FA, Bertolami MC, Neto A Afiune, Souza AD, Lottenberg AM, Chacra AP, Faludi AA, Loures-Vale AA, et al: IV Brazilian Guideline for Dyslipidemia and Atherosclerosis prevention: Department of Atherosclerosis of Brazilian Society of Cardiology. Arq Bras Cardiol. 88(Suppl 1): 2–19. 2007.(In Portuguese). View Article : Google Scholar : PubMed/NCBI

40 

Cesarino CB, Cipullo JP, Martin JFV, Ciorlia LA, Godoy de MRP, Cordeiro JA and Rodrigues IC: Prevalência e fatores sociodemográficos em hipertensos de São José do Rio Preto-SP. Arq Bras Cardiol. 91:31–35. 2008. View Article : Google Scholar

41 

Rosário TM, Scala LC, França GV, Pereira MR and Jardim PC: Prevalence, control and treatment of arterial hypertension in Nobres-MT. Arq Bras Cardiol. 93:622–678. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Freitas LS and Garcia LP: Evolution of prevalence of diabetes and associated hypertension in Brazil: analysis of National Household Sample Survey, 1998, 2003 and 2008. Epidemiol Serv Saúde. 21:7–19. 2012.(In Portuguese). View Article : Google Scholar

43 

Malta DC, Moura EC, Silva SA, Oliveira PP and Silva VL: Prevalence of smoking among adults residing in the Federal District of Brasília and in the state capitals of Brazil, 2008. J Bras Pneumol. 36:75–83. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Hansson PO, Eriksson H, Welin L, Svärdsudd K and Wilhelmsen L: Smoking and abdominal obesity: Risk factors for venous thromboembolism among middle-aged men: ‘The study of men born in 1913’. Arch Intern Med. 159:1886–1890. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Wells PS, Anderson DR, Bormanis J, Guy F, Mitchell M, Gray L, Clement C, Robinson KS and Lewandowski B: Value of assessment of pretest probability of deep-vein thrombosis in clinical management. The Lancet. 350:1795–1818. 1997. View Article : Google Scholar

46 

de Moerloose P, Boehlen F and Neerman-Arbez M: Fibrinogen and the risk of thrombosis. Semin Thromb Hemost. 36:7–17. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Rennie J and Ogston D: Fibrinolytic activity in malignant disease. J Clin Pathol. 28:872–874. 1975. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Barbour Fernandes LF, Fregnani JH, Strunz CM, Nogueira Ad and Longatto‑Filho A: Role of P‑selectin in thromboembolic events in patients with cancer. Mol Clin Oncol 8: 188-196, 2018.
APA
Barbour Fernandes, L.F., Fregnani, J.H., Strunz, C.M., Nogueira, A.d., & Longatto‑Filho, A. (2018). Role of P‑selectin in thromboembolic events in patients with cancer. Molecular and Clinical Oncology, 8, 188-196. https://doi.org/10.3892/mco.2017.1482
MLA
Barbour Fernandes, L. F., Fregnani, J. H., Strunz, C. M., Nogueira, A. d., Longatto‑Filho, A."Role of P‑selectin in thromboembolic events in patients with cancer". Molecular and Clinical Oncology 8.1 (2018): 188-196.
Chicago
Barbour Fernandes, L. F., Fregnani, J. H., Strunz, C. M., Nogueira, A. d., Longatto‑Filho, A."Role of P‑selectin in thromboembolic events in patients with cancer". Molecular and Clinical Oncology 8, no. 1 (2018): 188-196. https://doi.org/10.3892/mco.2017.1482
Copy and paste a formatted citation
x
Spandidos Publications style
Barbour Fernandes LF, Fregnani JH, Strunz CM, Nogueira Ad and Longatto‑Filho A: Role of P‑selectin in thromboembolic events in patients with cancer. Mol Clin Oncol 8: 188-196, 2018.
APA
Barbour Fernandes, L.F., Fregnani, J.H., Strunz, C.M., Nogueira, A.d., & Longatto‑Filho, A. (2018). Role of P‑selectin in thromboembolic events in patients with cancer. Molecular and Clinical Oncology, 8, 188-196. https://doi.org/10.3892/mco.2017.1482
MLA
Barbour Fernandes, L. F., Fregnani, J. H., Strunz, C. M., Nogueira, A. d., Longatto‑Filho, A."Role of P‑selectin in thromboembolic events in patients with cancer". Molecular and Clinical Oncology 8.1 (2018): 188-196.
Chicago
Barbour Fernandes, L. F., Fregnani, J. H., Strunz, C. M., Nogueira, A. d., Longatto‑Filho, A."Role of P‑selectin in thromboembolic events in patients with cancer". Molecular and Clinical Oncology 8, no. 1 (2018): 188-196. https://doi.org/10.3892/mco.2017.1482
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team