Two‑stage study of lung cancer risk modification by a functional variant in the 3'‑untranslated region of SMAD5 based on the bone morphogenetic protein pathway

Zhang,Zili; Wang,Jian; Zeng,Xiansheng; Li,Defu; Ding,Mingjing; Guan,Ruijuan; Yuan,Liang; Zhou,Qipeng; Guo,Meihua; Xiong,Mingmei; Dong,Lian; Lu,Wenju

doi:10.3892/mco.2017.1490

January-2018 Volume 8 Issue 1

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January-2018 Volume 8 Issue 1

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Article Open Access

Two‑stage study of lung cancer risk modification by a functional variant in the 3'‑untranslated region of SMAD5 based on the bone morphogenetic protein pathway

Authors:
- Zili Zhang
- Jian Wang
- Xiansheng Zeng
- Defu Li
- Mingjing Ding
- Ruijuan Guan
- Liang Yuan
- Qipeng Zhou
- Meihua Guo
- Mingmei Xiong
- Lian Dong
- Wenju Lu
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Affiliations: State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China, Department of Respiratory Medicine, Xiangyang Central Hospital, Xiangyang, Hubei 441021, P.R. China, Department of Respiratory Medicine, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, Inner Mongolia Autonomous Region, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 38-46
|
Published online on: November 6, 2017

https://doi.org/10.3892/mco.2017.1490
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Abstract

Increasing evidence supports a key role for the bone morphogenetic protein (BMP) signaling pathway in lung vasculogenesis and angiogenesis. Genetic variations in BMP genes have been found to be correlated with cancer risk. In particular, the mutation in the 3'‑untranslated region of BMPs may significantly affect gene function, leading to cancer susceptibility. The aim of the present study was to determine whether genetic variations in the components of the BMP family are associated with lung cancer risk. A total of 314 tag single‑nucleotide polymorphisms were identified in 18 genes, which are considered to either compose or regulate BMPs, and their association with lung cancer risk was evaluated in a two‑stage case‑control study with 4,680 cases and controls. A consistently significant association of SMAD5 rs12719482 with elevated lung cancer risk was observed in the three types of sources of populations (adjusted additive model in the combined population: Odds ratio=1.32, 95% confidence interval: 1.16‑1.51). The lung cancer risk statistically significantly increased with the increasing number of variant alleles of SMAD5 rs12719482 in a dose‑dependent pattern (P for trend=4.9x10‑5). Consistent evidence was identified for a significant interaction between the rs12719482 and cigarette smoking, performed as either a continuous or discrete variable. These findings indicated that SMAD5 rs12719482 may be a possible candidate marker for susceptibility to lung cancer in the Chinese population.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Two‑stage study of lung cancer risk modification by a functional variant in the 3'‑untranslated region of SMAD5 based on the bone morphogenetic protein pathway

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