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Article

Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma

  • Authors:
    • Kayhan Erturk
    • Faruk Tas
    • Murat Serilmez
    • Elif Bilgin
    • Derya Duranyildiz
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Institute of Oncology, University of Istanbul, Istanbul 34093, Turkey
  • Pages: 204-208
    |
    Published online on: November 8, 2017
       https://doi.org/10.3892/mco.2017.1493
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Abstract

Neural precursor cell‑expressed developmentally downregulated protein 9 (NEDD9) is a promoter for various cellular functions that result in tumorigenesis. The aim of the present study was to analyse the serum levels of NEDD9 in melanoma patients in order to evaluate its prognostic, predictive and diagnostic value. Data from 112 melanoma patients were retrospectively analyzed and ELISA assays were used to measure serum NEDD9 concentration. The median serum NEDD9 levels of the patients were significantly higher compared with those of the controls. Serum NEDD9 was not found to be associated with any of the clinicopathological parameters, and was also not found to be prognostic for survival in melanoma. Therefore, serum NEDD9 may be of diagnostic value in melanoma, but its usefulness in prognosis remains controversial. The important role of NEDD9 in tumor angiogenesis necessitates efforts to elucidate its interactions with the tumor microenvironment and its potential as a therapeutic target for malignancies.
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1 

Tikhmyanova N and Golemis EA: NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PLoS One. 6:e221022011. View Article : Google Scholar : PubMed/NCBI

2 

Defilippi P, Di Stefano P and Cabodi S: p130Cas: A versatile scaffold in signaling networks. Trends Cell Biol. 16:257–263. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Singh M, Cowell L, Seo S, O'Neill G and Golemis E: Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle. Cell Biochem Biophys. 48:54–72. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Tikhmyanova N, Little JL and Golemis EA: CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci. 67:1025–1048. 2010. View Article : Google Scholar : PubMed/NCBI

5 

O'Neill GM, Seo S, Serebriiskii IG, Lessin SR and Golemis EA: A new central scaffold for metastasis: Parsing HEF1/Cas-L/NEDD9. Cancer Res. 67:8975–8979. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, et al: NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 69:7198–7206. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Shagisultanova E, Gaponova AV, Gabbasov R, Nicolas E and Golemis EA: Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene. 567:1–11. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Balch CM, Gershenwald JE, Soong S, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, et al: Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 27:6199–6206. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

10 

van der Flier S, Brinkman A, Look MP, Kok EM, Meijer-van Gelder ME, Klijn JG, Dorssers LC and Foekens JA: Bcar1/p130Cas protein and primary breast cancer: Prognosis and response to tamoxifen treatment. J Natl Cancer Inst. 92:120–127. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Natarajan M, Stewart JE, Golemis EA, Pugacheva EN, Alexandropoulos K, Cox BD, Wang W, Grammer JR and Gladson CL: HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene. 25:1721–1732. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, et al: Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125:1269–1281. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Huber MA, Kraut N and Beug H: Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol. 17:548–558. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Bui LC, Tomkiewicz C, Chevallier A, Pierre S, Bats AS, Mota S, Raingeaud J, Pierre J, Diry M, Transy C, et al: Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. Oncogene. 28:3642–3651. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Rozenberg GI, Monahan KB, Torrice C, Bear JE and Sharpless NE: Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation. Melanoma Res. 20:361–371. 2010.PubMed/NCBI

16 

Singh MK, Izumchenko E, Klein-Szanto AJ, Egleston BL, Wolfson M and Golemis EA: Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. Cancer Res. 70:8907–8916. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL and Massagué J: Genes that mediate breast cancer metastasis to lung. Nature. 436:518–524. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Dadke D, Jarnik M, Pugacheva EN, Singh MK and Golemis EA: Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell. 17:1204–1217. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Domingues MJ, Rambow F, Job B, Papon L, Liu W, Larue L and Bonaventure J: β-catenin inhibitor ICAT modulates the invasive motility of melanoma cells. Cancer Res. 74:1983–1995. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, et al: An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest. 121:880–892. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, et al: Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer. Clin Cancer Res. 18:6326–6338. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Jin Y, Li F, Zheng C, Wang Y, Fang Z, Guo C, Wang X, Liu H, Deng L, Li C, et al: NEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transition. Int J Cancer. 134:2294–2304. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Zhang SS, Wu LH, Liu Q, Chen KS and Zhang XF: Elevated expression of NEDD9 is associated with metastatic activity in gastric cancer. Onco Targets Ther. 8:633–640. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Liu Y, Wang D, Zhao KL, Zhu JW, Yin HB, Wei YZ, Wu ZJ, Cheng GJ, Wang F, Ni F, et al: NEDD9 overexpression correlates with poor prognosis in gastric cancer. Tumour Biol. 35:6351–6356. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Shi R, Wang L, Wang T, Xu J, Wang F and Xu M: NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma. Med Oncol. 31:8522014. View Article : Google Scholar : PubMed/NCBI

26 

Karabulut M, Alis H, Afsar CU, Karabulut S, Kocatas A, Oguz H and Aykan NF: Serum neural precursor cell-expressed, developmentally down regulated 9 (NEDD9) level may have a prognostic role in patients with gastric cancer. Biomed Pharmacother. 73:140–146. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Xue YZ, Sheng YY, Liu ZL, Wei ZQ, Cao HY, Wu YM, Lu YF, Yu LH, Li JP and Li ZS: Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance. Tumour Biol. 34:895–899. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Lu P, Wang ZP, Dang Z, Zheng ZG, Li X, Zhou L, Ding R, Yue SQ and Dou KF: Expression of NEDD9 in hepatocellular carcinoma and its clinical significance. Oncol Rep. 33:2375–2383. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Li P, Zhou H, Zhu X, Ma G, Liu C, Lin B and Mao W: High expression of NEDD9 predicts adverse outcomes of colorectal cancer patients. Int J Clin Exp Pathol. 7:2565–2570. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Erturk K, Tas F, Serilmez M, Bilgin E and Duranyildiz D: Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma. Mol Clin Oncol 8: 204-208, 2018.
APA
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., & Duranyildiz, D. (2018). Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma. Molecular and Clinical Oncology, 8, 204-208. https://doi.org/10.3892/mco.2017.1493
MLA
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Duranyildiz, D."Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma". Molecular and Clinical Oncology 8.1 (2018): 204-208.
Chicago
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Duranyildiz, D."Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma". Molecular and Clinical Oncology 8, no. 1 (2018): 204-208. https://doi.org/10.3892/mco.2017.1493
Copy and paste a formatted citation
x
Spandidos Publications style
Erturk K, Tas F, Serilmez M, Bilgin E and Duranyildiz D: Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma. Mol Clin Oncol 8: 204-208, 2018.
APA
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., & Duranyildiz, D. (2018). Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma. Molecular and Clinical Oncology, 8, 204-208. https://doi.org/10.3892/mco.2017.1493
MLA
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Duranyildiz, D."Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma". Molecular and Clinical Oncology 8.1 (2018): 204-208.
Chicago
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Duranyildiz, D."Significance of serum neural precursor cell‑expressed developmentally downregulated protein 9 in melanoma". Molecular and Clinical Oncology 8, no. 1 (2018): 204-208. https://doi.org/10.3892/mco.2017.1493
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