Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2018 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2018 Volume 8 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Circadian clock and oral cancer (Review)

  • Authors:
    • Minou Nirvani
    • Cuong Khuu
    • Tor Paaske Utheim
    • Lars Peter Sand
    • Amer Sehic
  • View Affiliations / Copyright

    Affiliations: Department of Oral Biology, Faculty of Dentistry, University of Oslo, 0316 Oslo, Norway
    Copyright: © Nirvani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 219-226
    |
    Published online on: November 27, 2017
       https://doi.org/10.3892/mco.2017.1518
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The circadian clock is comprised of a master component situated in the hypothalamic suprachiasmatic nucleus and subordinate clock genes in almost every cell of the body. The circadian clock genes and their encoded proteins govern the organism to follow the natural signals of time, and adapt to external changes in the environment. The majority of physiological processes in mammals exhibit variable circadian rhythms, which are generated and coordinated by an oscillation in the expression of the clock genes. A number of studies have reported that alteration in the expression level of clock genes is correlated with several pathological conditions, including cancer. However, little is known about the role of clock genes in homeostasis of the oral epithelium and their disturbances in oral carcinogenesis. The present review summarizes the current state of knowledge of the implications of clock genes in oral cancer. It has been demonstrated that the development of oral squamous cell carcinoma undergoes circadian oscillation in relation to tumor volume and proliferation rate. The circadian clock gene period (PER)1 has been associated with oral cancer pathogenesis and it is suggested that changes in the expression of PER1 may exhibit an important role in the development, invasion, and metastasis of oral squamous cell carcinoma. However, its role remains elusive and there is a need for further research in order to understand the underlying mechanisms of the clock genes in oral cancer pathogenesis.
View Figures

Figure 1

View References

1 

Moore RY: The suprachiasmatic nucleus and the circadian timing system. Prog Mol Biol Transl Sci. 119:1–28. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Soták M, Sumová A and Pácha J: Cross-talk between the circadian clock and the cell cycle in cancer. Ann Med. 46:221–232. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Fu L, Pelicano H, Liu J, Huang P and Lee C: The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 111:41–50. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Hunt T and Sassone-Corsi P: Riding tandem: Circadian clocks and the cell cycle. Cell. 129:461–464. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Hrushesky WJ, Grutsch J, Wood P, Yang X, Oh EY, Ansell C, Kidder S, Ferrans C, Quiton DF, Reynolds J, et al: Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms. Integr Cancer Ther. 8:387–397. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Gery S and Koeffler HP: Circadian rhythms and cancer. Cell Cycle. 9:1097–1103. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Roenneberg T and Merrow M: Circadian clocks-the fall and rise of physiology. Nat Rev Mol Cell Biol. 6:965–971. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Grimaldi B, Nakahata Y, Kaluzova M, Masubuchi S and Sassone-Corsi P: Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1. Int J Biochem Cell Biol. 41:81–86. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Aschoff J, Fatranská M, Giedke H, Doerr P, Stamm D and Wisser H: Human circadian rhythms in continuous darkness: Entrainment by social cues. Science. 171:213–215. 1971. View Article : Google Scholar : PubMed/NCBI

10 

Rosato E and Kyriacou CP: Origins of circadian rhythmicity. J Biol Rhythms. 17:506–511. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Schibler U and Sassone-Corsi P: A web of circadian pacemakers. Cell. 111:919–922. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Whitmore D, Foulkes NS and Sassone-Corsi P: Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Nature. 404:87–91. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Reppert SM and Weaver DR: Coordination of circadian timing in mammals. Nature. 418:935–941. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Golombek DA and Rosenstein RE: Physiology of circadian entrainment. Physiol Rev. 90:1063–1102. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, et al: Interacting molecular loops in the mammalian circadian clock. Science. 288:1013–1019. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Giebultowicz JM: Peripheral clocks and their role in circadian timing: Insights from insects. Philos Trans R Soc Lond B Biol Sci. 356:1791–1799. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U and Schibler U: The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 110:251–260. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, et al: Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature. 485:123–127. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA and Hogenesch JB: A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 43:527–537. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Padmanabhan K, Robles MS, Westerling T and Weitz CJ: Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 337:599–602. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Duong HA, Robles MS, Knutti D and Weitz CJ: A molecular mechanism for circadian clock negative feedback. Science. 332:1436–1439. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Novák B and Tyson JJ: Design principles of biochemical oscillators. Nat Rev Mol Cell Biol. 9:981–991. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Nishide SY, Honma S, Nakajima Y, Ikeda M, Baba K, Ohmiya Y and Honma K: New reporter system for Per1 and Bmal1 expressions revealed self-sustained circadian rhythms in peripheral tissues. Genes Cells. 11:1173–1182. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ, et al: PERIOD2: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA. 101:pp. 5339–5346. 2004; View Article : Google Scholar : PubMed/NCBI

25 

Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, Smith AG, Gant TW, Hastings MH and Kyriacou CP: Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol. 12:540–550. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Duffield GE, Best JD, Meurers BH, Bittner A, Loros JJ and Dunlap JC: Circadian programs of transcriptional activation, signaling, and protein turnover revealed by microarray analysis of mammalian cells. Curr Biol. 12:551–557. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M and Kay SA: Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci. 22:9305–9319. 2002.PubMed/NCBI

28 

Unsal-Kaçmaz K, Mullen TE, Kaufmann WK and Sancar A: Coupling of human circadian and cell cycles by the timeless protein. Mol Cell Biol. 25:3109–3116. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR and Lee C: The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci USA. 108:pp. 16451–16456. 2011; View Article : Google Scholar : PubMed/NCBI

30 

Costa G, Haus E and Stevens R: Shift work and cancer-considerations on rationale, mechanisms and epidemiology. Scand J Work Environ Health. 36:163–179. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, Fuchs CS and Colditz GA: Night-shift work and risk of colorectal cancer in the nurses' health study. J Natl Cancer Inst. 95:825–828. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Kubo T, Ozasa K, Mikami K, Wakai K, Fujino Y, Watanabe Y, Miki T, Nakao M, Hayashi K, Suzuki K, et al: Prospective cohort study of the risk of prostate cancer among rotating-shift workers: Findings from the Japan collaborative cohort study. Am J Epidemiol. 164:549–555. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Viswanathan AN, Hankinson SE and Schernhammer ES: Night shift work and the risk of endometrial cancer. Cancer Res. 67:10618–10622. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Lahti TA, Partonen T, Kyyrönen P, Kauppinen T and Pukkala E: Night-time work predisposes to non-Hodgkin lymphoma. Int J Cancer. 123:2148–2151. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Stevens RG: Artificial lighting in the industrialized world: Circadian disruption and breast cancer. Cancer Causes Control. 17:501–507. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Touitou Y, Bogdan A, Lévi F, Benavides M and Auzéby A: Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients: Relationships with tumour marker antigens. Br J Cancer. 74:1248–1252. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Panzer A: Melatonin in osteosarcoma: An effective drug? Med Hypotheses. 48:523–525. 1997. View Article : Google Scholar : PubMed/NCBI

38 

Skibola CF, Holly EA, Forrest MS, Hubbard A, Bracci PM, Skibola DR, Hegedus C and Smith MT: Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 13:779–786. 2004.PubMed/NCBI

39 

Kloog I, Haim A, Stevens RG and Portnov BA: Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men. Chronobiol Int. 26:108–125. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Bhatti P, Mirick DK and Davis S: Invited commentary: Shift work and cancer. Am J Epidemiol. 176:760–765. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Buzzelli G, Dattolo P, Pinzani M, Brocchi A, Romano S and Gentilini P: Circulating growth hormone and insulin-like growth factor-I in nonalcoholic liver cirrhosis with or without superimposed hepatocarcinoma: Evidence of an altered circadian rhythm. Am J Gastroenterol. 88:1744–1748. 1993.PubMed/NCBI

42 

Rafnsson V, Tulinius H, Jónasson JG and Hrafnkelsson J: Risk of breast cancer in female flight attendants: A population-based study (Iceland). Cancer Causes Control. 12:95–101. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Scheer FA, Hilton MF, Mantzoros CS and Shea SA: Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA. 106:pp. 4453–4458. 2009; View Article : Google Scholar : PubMed/NCBI

44 

Straif K, Baan R, Grosse Y, Secretan B, Ghissassi FE, Bouvard V, Altieri A, Benbrahim-Tallaa L and Cogliano V; WHO, ; International Agency for Research on Cancer Monograph Working Group, : Carcinogenicity of shift-work, painting and fire-fighting. Lancet Oncol. 8:1065–1066. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Hsu CM, Lin SF, Lu CT, Lin PM and Yang MY: Altered expression of circadian clock genes in head and neck squamous cell carcinoma. Tumour Biol. 33:149–155. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Haus EL and Smolensky MH: Shift work and cancer risk: Potential mechanistic roles of circadian disruption, light at night and sleep deprivation. Sleep Med Rev. 17:273–284. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I and Colditz GA: Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst. 93:1563–1568. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, Castaño-Vinyals G, Davis S, Frings-Dresen MH, Fritschi L, et al: Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup Environ Med. 68:154–162. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Pukkala E, Aspholm R, Auvinen A, Eliasch H, Gundestrup M, Haldorsen T, Hammar N, Hrafnkelsson J, Kyyrönen P, Linnersjö A, et al: Incidence of cancer among Nordic airline pilots over five decades: Occupational cohort study. BMJ. 325:5672002. View Article : Google Scholar : PubMed/NCBI

50 

Feychting M, Osterlund B and Ahlbom A: Reduced cancer incidence among the blind. Epidemiology. 9:490–494. 1998. View Article : Google Scholar : PubMed/NCBI

51 

Kliukiene J, Tynes T and Andersen A: Risk of breast cancer among Norwegian women with visual impairment. Br J Cancer. 84:397–399. 2001. View Article : Google Scholar : PubMed/NCBI

52 

Verkasalo PK, Pukkala E, Stevens RG, Ojamo M and Rudanko SL: Inverse association between breast cancer incidence and degree of visual impairment in Finland. Br J Cancer. 80:1459–1460. 1999. View Article : Google Scholar : PubMed/NCBI

53 

Rich T, Innominato PF, Boerner J, Mormont MC, Iacobelli S, Baron B, Jasmin C and Lévi F: Elevated serum cytokines correlated with altered behavior, serum cortisol rhythm, and dampened 24-hour rest-activity patterns in patients with metastatic colorectal cancer. Clin Cancer Res. 11:1757–1764. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Sephton SE, Sapolsky RM, Kraemer HC and Spiegel D: Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst. 92:994–1000. 2000. View Article : Google Scholar : PubMed/NCBI

55 

Kim KS, Kim YC, Oh IJ, Kim SS, Choi JY and Ahn RS: Association of worse prognosis with an aberrant diurnal cortisol rhythm in patients with advanced lung cancer. Chronobiol Int. 29:1109–1120. 2012. View Article : Google Scholar : PubMed/NCBI

56 

Sephton SE, Lush E, Dedert EA, Floyd AR, Rebholz WN, Dhabhar FS, Spiegel D and Salmon P: Diurnal cortisol rhythm as a predictor of lung cancer survival. Brain Behav Immun. 30 Suppl:S163–S170. 2013. View Article : Google Scholar : PubMed/NCBI

57 

Innominato PF, Giacchetti S, Bjarnason GA, Focan C, Garufi C, Coudert B, Iacobelli S, Tampellini M, Durando X, Mormont MC, et al: Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer. Int J Cancer. 131:2684–2692. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Wu HS, Davis JE and Natavio T: Fatigue and disrupted sleep-wake patterns in patients with cancer: A shared mechanism. Clin J Oncol Nurs. 16:E56–E68. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Innominato PF, Focan C, Gorlia T, Moreau T, Garufi C, Waterhouse J, Giacchetti S, Coudert B, Iacobelli S, Genet D, et al: Circadian rhythm in rest and activity: A biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer. Cancer Res. 69:4700–4707. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Yi C, Mu L, de la Longrais IA, Sochirca O, Arisio R, Yu H, Hoffman AE, Zhu Y and Katsaro D: The circadian gene NPAS2 is a novel prognostic biomarker for breast cancer. Breast Cancer Res Treat. 120:663–669. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H and Hengstler JG: Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 13:3282–3291. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Zhu Y, Stevens RG, Leaderer D, Hoffman A, Holford T, Zhang Y, Brown HN and Zheng T: Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. Breast Cancer Res Treat. 107:421–425. 2008. View Article : Google Scholar : PubMed/NCBI

63 

Xue X, Liu F, Han Y, Li P, Yuan B, Wang X, Chen Y, Kuang Y, Zhi Q and Zhao H: Silencing NPAS2 promotes cell growth and invasion in DLD-1 cells and correlated with poor prognosis of colorectal cancer. Biochem Biophys Res Commun. 450:1058–1062. 2014. View Article : Google Scholar : PubMed/NCBI

64 

Xiao L, Chang AK, Zang MX, Bi H, Li S, Wang M, Xing X and Wu H: Induction of the CLOCK gene by E2-ERα signaling promotes the proliferation of breast cancer cells. PLoS One. 9:e958782014. View Article : Google Scholar : PubMed/NCBI

65 

Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, Numata K, Shiozawa M, Rino Y, Tanaka K, et al: Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 25:1439–1446. 2011. View Article : Google Scholar : PubMed/NCBI

66 

Mazzoccoli G, Panza A, Valvano MR, Palumbo O, Carella M, Pazienza V, Biscaglia G, Tavano F, Di Sebastiano P, Andriulli A and Piepoli A: Clock gene expression levels and relationship with clinical and pathological features in colorectal cancer patients. Chronobiol Int. 28:841–851. 2011. View Article : Google Scholar : PubMed/NCBI

67 

Relles D, Sendecki J, Chipitsyna G, Hyslop T, Yeo CJ and Arafat HA: Circadian gene expression and clinicopathologic correlates in pancreatic cancer. J Gastrointest Surg. 17:443–450. 2013. View Article : Google Scholar : PubMed/NCBI

68 

Hu ML, Yeh KT, Lin PM, Hsu CM, Hsiao HH, Liu YC, Lin HY, Lin SF and Yang MY: Deregulated expression of circadian clock genes in gastric cancer. BMC Gastroenterol. 14:672014. View Article : Google Scholar : PubMed/NCBI

69 

Mazzoccoli G, Piepoli A, Carella M, Panza A, Pazienza V, Benegiamo G, Palumbo O and Ranieri E: Altered expression of the clock gene machinery in kidney cancer patients. Biomed Pharmacother. 66:175–179. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Liu B, Xu K, Jiang Y and Li X: Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer. Int J Clin Exp Pathol. 7:7863–7871. 2014.PubMed/NCBI

71 

Cao Q, Gery S, Dashti A, Yin D, Zhou Y, Gu J and Koeffler HP: A role for the clock gene per1 in prostate cancer. Cancer Res. 69:7619–7625. 2009. View Article : Google Scholar : PubMed/NCBI

72 

Yang X, Wood PA, Oh EY, Du-Quiton J, Ansell CM and Hrushesky WJ: Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res Treat. 117:423–431. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Mao Y, Fu A, Hoffman AE, Jacobs DI, Jin M, Chen K and Zhu Y: The circadian gene CRY2 is associated with breast cancer aggressiveness possibly via epigenomic modifications. Tumour Biol. 36:3533–3539. 2015. View Article : Google Scholar : PubMed/NCBI

74 

Markt SC, Valdimarsdottir UA, Shui IM, Sigurdardottir LG, Rider JR, Tamimi RM, Batista JL, Haneuse S, Flynn-Evans E, Lockley SW, et al: Circadian clock genes and risk of fatal prostate cancer. Cancer Causes Control. 26:25–33. 2015. View Article : Google Scholar : PubMed/NCBI

75 

Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, Hogenesch JB, Simon MC, Takahashi JS and Bradfield CA: Mop3 is an essential component of the master circadian pacemaker in mammals. Cell. 103:1009–1017. 2000. View Article : Google Scholar : PubMed/NCBI

76 

Zeng ZL, Luo HY, Yang J, Wu WJ, Chen DL, Huang P and Xu RH: Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer. Clin Cancer Res. 20:1042–1052. 2014. View Article : Google Scholar : PubMed/NCBI

77 

Jiang W, Zhao S, Jiang X, Zhang E, Hu G, Hu B, Zheng P, Xiao J, Lu Z, Lu Y, et al: The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway. Cancer Lett. 371:314–325. 2016. View Article : Google Scholar : PubMed/NCBI

78 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

79 

Warnakulasuriya S: Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 45:309–316. 2009. View Article : Google Scholar : PubMed/NCBI

80 

Sanderson RJ, de Boer MF, Damhuis RA, Meeuwis CA and Knegt PP: The influence of alcohol and smoking on the incidence of oral and oropharyngeal cancer in women. Clin Otolaryngol Allied Sci. 22:444–448. 1997. View Article : Google Scholar : PubMed/NCBI

81 

Scully C and Field J: Genetic aberrations in squamous cell carcinoma of the head and neck (SCCHN), with reference to oral carcinoma (review). Int J Oncol. 10:5–21. 1997.PubMed/NCBI

82 

Yuan H, Li H, Ma H, Niu Y, Wu Y, Zhang S, Hu Z, Shen H and Chen N: Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Exp Ther Med. 3:719–724. 2012. View Article : Google Scholar : PubMed/NCBI

83 

Zhang J, Gao F, Yang AK, Chen WK, Chen SW, Li H, Zhang X, Yang ZY, Chen XL and Song M: Epidemiologic characteristics of oral cancer: Single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center. Chin J Cancer. 35:242016. View Article : Google Scholar : PubMed/NCBI

84 

Amit M, Yen TC, Liao CT, Chaturvedi P, Agarwal JP, Kowalski LP, Ebrahimi A, Clark JR, Kreppel M, Zöller J, et al: Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study. Cancer. 119:4242–4248. 2013. View Article : Google Scholar : PubMed/NCBI

85 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

86 

Sand L, Wallström M and Hirsch JM: Smokeless tobacco, viruses and oral cancer. Oral Health Dent Manag. 13:372–378. 2014.PubMed/NCBI

87 

Listl S, Jansen L, Stenzinger A, Freier K, Emrich K, Holleczek B, Katalinic A, Gondos A and Brenner H; GEKID Cancer Survival Working Group, : Survival of patients with oral cavity cancer in Germany. PLoS One. 8:e534152013. View Article : Google Scholar : PubMed/NCBI

88 

Engholm G, Ferlay J, Christensen N, Bray F, Gjerstorff ML, Klint A, Køtlum JE, Olafsdóttir E, Pukkala E and Storm HH: NORDCAN-a Nordic tool for cancer information, planning, quality control and research. Acta Oncol. 49:725–736. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Zieker D, Jenne I, Koenigsrainer I, Zdichavsky M, Nieselt K, Buck K, Zieker J, Beckert S, Glatzle J, Spanagel R, et al: Circadian expression of clock- and tumor suppressor genes in human oral mucosa. Cell Physiol Biochem. 26:155–166. 2010. View Article : Google Scholar : PubMed/NCBI

90 

Bjarnason GA, Jordan RC, Wood PA, Li Q, Lincoln DW, Sothern RB, Hrushesky WJ and Ben-David Y: Circadian expression of clock genes in human oral mucosa and skin: Association with specific cell-cycle phases. Am J Pathol. 158:1793–1801. 2001. View Article : Google Scholar : PubMed/NCBI

91 

Mullenders J, Fabius AW, Madiredjo M, Bernards R and Beijersbergen RL: A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One. 4:e47982009. View Article : Google Scholar : PubMed/NCBI

92 

Miki T, Matsumoto T, Zhao Z and Lee CC: p53 regulates Period2 expression and the circadian clock. Nat Commun. 4:24442013. View Article : Google Scholar : PubMed/NCBI

93 

Zeng ZL, Wu MW, Sun J, Sun YL, Cai YC, Huang YJ and Xian LJ: Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity. J Biochem. 148:319–326. 2010. View Article : Google Scholar : PubMed/NCBI

94 

Chen R, Yang K, Zhao NB, Zhao D, Chen D, Zhao CR and Tang H: Abnormal expression of PER1 circadian-clock gene in oral squamous cell carcinoma. Onco Targets Ther. 5:403–407. 2012.PubMed/NCBI

95 

Li HX, Fu XJ, Yang K, Chen D, Tang H and Zhao Q: The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma. Oncotarget. 7:20574–20583. 2016. View Article : Google Scholar : PubMed/NCBI

96 

Zhao Q, Zheng G, Yang K, Ao YR, Su XL, Li Y and Lv XQ: The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. Oncotarget. 7:70290–70302. 2016.PubMed/NCBI

97 

Zhao N, Tang H, Yang K and Chen D: Circadian rhythm characteristics of oral squamous cell carcinoma growth in an orthotopic xenograft model. Onco Targets Ther. 6:41–46. 2013. View Article : Google Scholar : PubMed/NCBI

98 

Ye H, Yang K, Tan XM, Fu XJ and Li HX: Daily rhythm variations of the clock gene PER1 and cancer-related genes during various stages of carcinogenesis in a golden hamster model of buccal mucosa carcinoma. Onco Targets Ther. 8:1419–1426. 2015.PubMed/NCBI

99 

Gery S, Komatsu N, Baldjyan L, Yu A, Koo D and Koeffler HP: The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell. 22:375–382. 2006. View Article : Google Scholar : PubMed/NCBI

100 

Fu XJ, Li HX, Yang K, Chen D and Tang H: The important tumor suppressor role of PER1 in regulating the cyclin-CDK-CKI network in SCC15 human oral squamous cell carcinoma cells. Onco Targets Ther. 9:2237–2245. 2016.PubMed/NCBI

101 

Wang Q, Ao Y, Yang K, Tang H and Chen D: Circadian clock gene Per2 plays an important role in cell proliferation, apoptosis and cell cycle progression in human oral squamous cell carcinoma. Oncol Rep. 35:3387–3394. 2016. View Article : Google Scholar : PubMed/NCBI

102 

Tan XM, Ye H, Yang K, Chen D, Wang QQ, Tang H and Zhao NB: Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa. Sci Rep. 5:99972015. View Article : Google Scholar : PubMed/NCBI

103 

Sato F, Nagata C, Liu Y, Suzuki T, Kondo J, Morohashi S, Imaizumi T, Kato Y and Kijima H: PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells. J Biochem. 146:833–838. 2009. View Article : Google Scholar : PubMed/NCBI

104 

Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y and Kijima H: PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells. Eur J Cancer. 47:1747–1758. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nirvani M, Khuu C, Utheim TP, Sand LP and Sehic A: Circadian clock and oral cancer (Review). Mol Clin Oncol 8: 219-226, 2018.
APA
Nirvani, M., Khuu, C., Utheim, T.P., Sand, L.P., & Sehic, A. (2018). Circadian clock and oral cancer (Review). Molecular and Clinical Oncology, 8, 219-226. https://doi.org/10.3892/mco.2017.1518
MLA
Nirvani, M., Khuu, C., Utheim, T. P., Sand, L. P., Sehic, A."Circadian clock and oral cancer (Review)". Molecular and Clinical Oncology 8.2 (2018): 219-226.
Chicago
Nirvani, M., Khuu, C., Utheim, T. P., Sand, L. P., Sehic, A."Circadian clock and oral cancer (Review)". Molecular and Clinical Oncology 8, no. 2 (2018): 219-226. https://doi.org/10.3892/mco.2017.1518
Copy and paste a formatted citation
x
Spandidos Publications style
Nirvani M, Khuu C, Utheim TP, Sand LP and Sehic A: Circadian clock and oral cancer (Review). Mol Clin Oncol 8: 219-226, 2018.
APA
Nirvani, M., Khuu, C., Utheim, T.P., Sand, L.P., & Sehic, A. (2018). Circadian clock and oral cancer (Review). Molecular and Clinical Oncology, 8, 219-226. https://doi.org/10.3892/mco.2017.1518
MLA
Nirvani, M., Khuu, C., Utheim, T. P., Sand, L. P., Sehic, A."Circadian clock and oral cancer (Review)". Molecular and Clinical Oncology 8.2 (2018): 219-226.
Chicago
Nirvani, M., Khuu, C., Utheim, T. P., Sand, L. P., Sehic, A."Circadian clock and oral cancer (Review)". Molecular and Clinical Oncology 8, no. 2 (2018): 219-226. https://doi.org/10.3892/mco.2017.1518
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team