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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-2018 Volume 8 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Xanthogranulomatous pituitary adenoma: A case report and literature review

  • Authors:
    • Guihong Li
    • Chaochao Zhang
    • Yuxue Sun
    • Qingchun Mu
    • Haiyan Huang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China
  • Pages: 445-448
    |
    Published online on: January 10, 2018
       https://doi.org/10.3892/mco.2018.1547
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Abstract

Xanthogranuloma, also referred to as cholesterol granuloma or xanthogranulomatous reaction, is a granulomatous lesion that is infrequently found in the sellar and parasellar regions. Xanthogranulomatous pituitary adenoma is relatively rare and, thus, the etiology, diagnosis, management and prognosis of this condition remain incompletely understood. We herein report the case of a 56‑year‑old female patient who presented to our institution with intermittent headache, vomiting and distending pain in the bilateral orbital regions. Brain magnetic resonance imaging revealed a sellar mass with a heterogeneous signal. The mass was subtotally resected, and histopathological examination confirmed the diagnosis of xanthogranulomatous pituitary adenoma. Although the patient's symptoms were relieved following surgical treatment, intractable hyponatremia and diabetes insipidus developed and she received hormone replacement therapy. At the last follow‑up (November 2016), the patient remained recurrence‑free. A total of 14 cases of pituitary adenoma with concomitant xanthogranuloma were identified in the literature, and the clinical and radiological manifestations are discussed. Sellar xanthogranuloma is usually associated with craniopharyngioma or Rathke's cleft cyst; however, it may also occur in isolation. Xanthogranulomatous pituitary adenomas are infrequent, making their diagnosis challenging. Surgical resection is the preferred treatment, and attention should be paid to postoperative hypopituitarism and development of diabetes insipidus.
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1 

Nishioka H, Shibuya M, Ohtsuka K, Ikeda Y and Haraoka J: Endocrinological and MRI features of pituitary adenomas with marked xanthogranulomatous reaction. Neuroradiology. 52:997–1002. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Paulus W, Honegger J, Keyvani K and Fahlbusch R: Xanthogranuloma of the sellar region: A clinicopathological entity different from adamantinomatous craniopharyngioma. Acta Neuropathol. 97:377–382. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Shirataki K, Okada S and Matsumoto S: Histopathological study of the ‘cholesterol granuloma reaction’ in the sellar and juxta-sellar tumors. No To Shinkei. 40:133–139. 1988.(In Japanese). PubMed/NCBI

4 

Yokoyama S, Goto M, Hirano H, Hirakawa W, Noguchi S, Hirahara K, Kadota K and Asakura T: Pituitary adenoma with cholesterol clefts. Endocr Pathol. 9:91–95. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Miyajima Y, Oka H, Utsuki S and Fujii K: Rathke's cleft cyst with xanthogranulomatous change-case report. Neurol Med Chir. 51:740–742. 2011. View Article : Google Scholar

6 

Rahmani R, Sukumaran M, Donaldson AM, Akselrod O, Lavi E and Schwartz TH: Parasellar xanthogranulomas. J Neurosurg. 122:812–817. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Bao SS and Rapp R: Xanthogranuloma as an unsuspected cause of idiopathic central diabetes insipidus. Endocr Pract. 20:e42–e46. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ben Nsir A, Thai QA, Chaieb L and Jemel H: Calcified suprasellar xanthogranuloma presenting with primary amenorrhea in a 17-year-old girl: Case report and literature review. World Neurosurg. 84:866.e11–e14. 2015. View Article : Google Scholar

9 

Kamoshima Y, Sawamura Y, Motegi H, Kubota K and Houkin K: Xanthogranuloma of the sellar region of children: Series of five cases and literature review. Neurol Med Chir (Tokyo). 51:689–693. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Madan Mohan B, Mohamed E, Jain SK, Jain M and Jaiswal AK: Serial MR imaging in suprasellar xanthogranuloma: Growth pattern and new lesions. J Neuroimaging. 25:677–679. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Vajtai I, Kopniczky Z, Buza Z, Kovács J, Kovács Z, Varga Z, Bodosi M and Paulus W: Cholesterol granuloma at the sella region: A new method of the differential diagnosis of craniopharyngioma. Orv Hetil. 142:451–457. 2001.(In Hungarian). PubMed/NCBI

12 

Amano K, Kubo O, Komori T, Tanaka M, Kawamata T, Hori T and Okada Y: Clinicopathological features of sellar region xanthogranuloma: Correlation with Rathke's cleft cyst. Brain Tumor Pathol. 30:233–241. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Burt MG, Morey AL, Turner JJ, Pell M, Sheehy JP and Ho KK: Xanthomatous pituitary lesions: A report of two cases and review of the literature. Pituitary. 6:161–168. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Gopal-Kothandapani JS, Bagga V, Wharton SB, Connolly DJ, Sinha S and Dimitri PJ: Xanthogranulomatous hypophysitis: A rare and often mistaken pituitary lesion. Endocrinol Diabetes Metab Case Rep. 2015:1400892015.PubMed/NCBI

15 

Yokoyama S, Sano T, Tajitsu K and Kusumoto K: Xanthogranulomatous hypophysitis mimicking a pituitary neoplasm. Endocr Pathol. 15:351–357. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Abla AA, Wilson DA, Eschbacher JM and Spetzler RF: Neurosurgical biopsy as the initial diagnosis of xanthogranuloma of the Erdheim-Chester disease variety of the infundibulum and optic apparatus: Letter to the editor. Acta Neurochir (Wien). 152:925–927. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Reithmeier T, Trost HA, Wolf S, Stölzle A, Feiden W and Lumenta CB: Xanthogranuloma of the Erdheim-Chester type within the sellar region: Case report. Clin Neuropathol. 21:24–28. 2002.PubMed/NCBI

18 

Sulentić P, Cupić H, Cerina V and Vrkljan M: Xanthogranuloma of the sellar region in a patient with sarcoidosis. Acta Clin Croat. 49:61–65. 2010.PubMed/NCBI

19 

Liu ZH, Tzaan WC, Wu YY and Chen HC: Sellar xanthogranuloma manifesting as obstructive hydrocephalus. J Clin Neurosci. 15:929–933. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Sugata S, Hirano H, Yatsushiro K, Yunoue S, Nakamura K and Arita K: Xanthogranuloma in the suprasellar region. Neurol Med Chir. 49:124–127. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li G, Zhang C, Sun Y, Mu Q and Huang H: Xanthogranulomatous pituitary adenoma: A case report and literature review. Mol Clin Oncol 8: 445-448, 2018.
APA
Li, G., Zhang, C., Sun, Y., Mu, Q., & Huang, H. (2018). Xanthogranulomatous pituitary adenoma: A case report and literature review. Molecular and Clinical Oncology, 8, 445-448. https://doi.org/10.3892/mco.2018.1547
MLA
Li, G., Zhang, C., Sun, Y., Mu, Q., Huang, H."Xanthogranulomatous pituitary adenoma: A case report and literature review". Molecular and Clinical Oncology 8.3 (2018): 445-448.
Chicago
Li, G., Zhang, C., Sun, Y., Mu, Q., Huang, H."Xanthogranulomatous pituitary adenoma: A case report and literature review". Molecular and Clinical Oncology 8, no. 3 (2018): 445-448. https://doi.org/10.3892/mco.2018.1547
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Zhang C, Sun Y, Mu Q and Huang H: Xanthogranulomatous pituitary adenoma: A case report and literature review. Mol Clin Oncol 8: 445-448, 2018.
APA
Li, G., Zhang, C., Sun, Y., Mu, Q., & Huang, H. (2018). Xanthogranulomatous pituitary adenoma: A case report and literature review. Molecular and Clinical Oncology, 8, 445-448. https://doi.org/10.3892/mco.2018.1547
MLA
Li, G., Zhang, C., Sun, Y., Mu, Q., Huang, H."Xanthogranulomatous pituitary adenoma: A case report and literature review". Molecular and Clinical Oncology 8.3 (2018): 445-448.
Chicago
Li, G., Zhang, C., Sun, Y., Mu, Q., Huang, H."Xanthogranulomatous pituitary adenoma: A case report and literature review". Molecular and Clinical Oncology 8, no. 3 (2018): 445-448. https://doi.org/10.3892/mco.2018.1547
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