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Article Open Access

Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations

  • Authors:
    • Ming‑Szu Hung
    • Yu‑Hung Fang
    • Yu‑Ching Lin
    • Jr‑Hau Lung
    • Meng‑Jer Hsieh
    • Ying‑Huang Tsai
  • View Affiliations / Copyright

    Affiliations: Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi 61363, Taiwan, R.O.C., Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi 61363, Taiwan, R.O.C., Division of Pulmonary Infection and Critical Care, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Chiayi 61363, Taiwan, R.O.C.
    Copyright: © Hung et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 421-428
    |
    Published online on: January 10, 2018
       https://doi.org/10.3892/mco.2018.1550
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Abstract

The aim of the present retrospective cohort study was to elucidate the clinical presentation of epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitor (TKI) responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations. The cohort included 131 lung adenocarcinoma patients with common exon 19 or exon 21 EGFR mutations, who were receiving first‑line EGFR‑TKI therapy. The patient characteristics, treatment regimen and outcomes were recorded and analyzed. Of the 131 patients, 104 (79.3%) responded to treatment, while 27 (20.7%) did not. A significantly longer median progression‑free survival (PFS) [14.3, 95% confidence interval (CI): 12.2‑18.4 vs. 5.7, 95% CI: 2.7‑9.9 months; P<0.001] and overall survival (OS) (42.2, 95% CI: 28.1‑58.1 vs. 11.5, 95% CI: 8.3‑19.7 months; P<0.001) were observed in responders compared with non‑responders. In responders, bone [hazard ratio (HR)=1.87, 95% CI: 1.11‑3.20, P=0.021] and pleural (HR=2.40, 95% CI: 1.37‑4.22, P=0.002) metastasis were independent factors of PFS. Exon 19 mutations (HR=0.38, 95% CI: 0.19‑0.76, P=0.006), Eastern Cooperative Oncology Group performance status score ≥2 (HR=3.53, 95% CI: 1.42‑8.75, P=0.007) and bone metastasis (HR=2.01, 95% CI: 1.05‑3.85, P=0.034), were independent factors of OS. In non‑responders, smoking (HR=3.97, 95% CI: 1.13‑13.91, P=0.031) was an independent factor of PFS. Different survival‑associated factors were observed between EGFR‑TKI responders and non‑responders. The development of new treatment strategies should be advocated in EGFR‑TKI non‑responders.
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Copy and paste a formatted citation
Spandidos Publications style
Hung MS, Fang YH, Lin YC, Lung JH, Hsieh MJ and Tsai YH: Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations. Mol Clin Oncol 8: 421-428, 2018.
APA
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., & Tsai, Y. (2018). Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations. Molecular and Clinical Oncology, 8, 421-428. https://doi.org/10.3892/mco.2018.1550
MLA
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., Tsai, Y."Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations". Molecular and Clinical Oncology 8.3 (2018): 421-428.
Chicago
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., Tsai, Y."Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations". Molecular and Clinical Oncology 8, no. 3 (2018): 421-428. https://doi.org/10.3892/mco.2018.1550
Copy and paste a formatted citation
x
Spandidos Publications style
Hung MS, Fang YH, Lin YC, Lung JH, Hsieh MJ and Tsai YH: Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations. Mol Clin Oncol 8: 421-428, 2018.
APA
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., & Tsai, Y. (2018). Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations. Molecular and Clinical Oncology, 8, 421-428. https://doi.org/10.3892/mco.2018.1550
MLA
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., Tsai, Y."Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations". Molecular and Clinical Oncology 8.3 (2018): 421-428.
Chicago
Hung, M., Fang, Y., Lin, Y., Lung, J., Hsieh, M., Tsai, Y."Survival‑associated factors of first‑line EGFR‑tyrosine kinase inhibitor responders and non‑responders in lung adenocarcinoma patients with common EGFR mutations". Molecular and Clinical Oncology 8, no. 3 (2018): 421-428. https://doi.org/10.3892/mco.2018.1550
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