Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
March-2018 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma

  • Authors:
    • Kohei Nakamura
    • Kentaro Nakayama
    • Toshiko Minamoto
    • Tomoka Ishibashi
    • Kaori Sanuki
    • Hitomi Yamashita
    • Ruriko Ono
    • Hiroki Sasamori
    • Takayoshi Komatsu‑Fujii
    • Masako Ishikawa
    • Satoru Kyo
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan
    Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 429-433
    |
    Published online on: January 10, 2018
       https://doi.org/10.3892/mco.2018.1551
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the prognostic value of the Glasgow prognostic score (GPS) in endometrial carcinoma (EC). Patients with EC who underwent surgery at the Shimane University Hospital between January 1997 and December 2013 were enrolled (n=118). The associations between pretreatment GPS and clinical parameters, including age, histological type, International Federation of Gynecology and Obstetrics stage, tumor grade, carbohydrate antigen 19‑9 and carcinoembryonic antigen levels, progression‑free survival (PFS), and overall survival (OS), were investigated. Survival analysis was performed with the Kaplan‑Meier method, and prognostic factors were evaluated with Cox's proportional hazards regression model. A high pretreatment GPS was associated with advanced clinical stage, histological type and tumor grade (P<0.001, P=0.007 and P=0.006, respectively). Multivariate analysis identified a high GPS as an independent negative prognostic factor for PFS and OS (P=0.025 and P=0.044, respectively). Therefore, a high pretreatment GPS has prognostic value and the potential to be a predictive marker for surgical outcome in patients with EC. Evaluation of pretreatment GPS may aid in the identification of high‑risk populations, which may improve treatment selection and patient outcomes.
View Figures

Figure 1

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

SGO Clinical Practice Endometrial Cancer Working Group, ; Burke WM, Orr J, Leitao M, Salom E, Gehrig P, Olawaiye AB, Brewer M, Boruta D, Villella J, et al: Endometrial cancer: A review and current management strategies: Part I. Gynecol Oncol. 134:385–392. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ho CM, Chien TY, Huang SH, Wu CJ, Shih BY and Chang SC: Multivariate analysis of the prognostic factors and outcomes in early cervical cancer patients undergoing radical hysterectomy. Gynecol Oncol. 93:458–464. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 105:103–104. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Kamura T, Tsukamoto N, Tsuruchi N, Saito T, Matsuyama T, Akazawa K and Nakano H: Multivariate analysis of the histopathologic prognostic factors of cervical cancer in patients undergoing radical hysterectomy. Cancer. 69:181–186. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Takeda N, Sakuragi N, Takeda M, Okamoto K, Kuwabara M, Negishi H, Oikawa M, Yamamoto R, Yamada H and Fujimoto S: Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy. Acta Obstet Gynecol Scand. 81:1144–1151. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Fotiou S, Vlahos N, Kondi-Pafiti A, Zarganis P, Papakonstantinou K and Creatsas G: Intraoperative gross assessment of myometrial invasion and cervical involvement in endometrial cancer: Role of tumor grade and size. Gynecol Oncol. 112:517–520. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Lo KW, Cheung TH, Yim SF and Chung TK: Preoperative hysteroscopic assessment of cervical invasion by endometrial carcinoma: A retrospective study. Gynecol Oncol. 82:279–282. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Haldorsen IS, Berg A, Werner HM, Magnussen IJ, Helland H, Salvesen OO, Trovik J and Salvesen HB: Magnetic resonance imaging performs better than endocervical curettage for preoperative prediction of cervical stromal invasion in endometrial carcinomas. Gynecol Oncol. 126:413–418. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC and Clarke SJ: The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer. Crit Rev Oncol Hematol. 88:218–230. 2013. View Article : Google Scholar : PubMed/NCBI

11 

McMillan DC: Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care. 12:223–226. 2009. View Article : Google Scholar : PubMed/NCBI

12 

McMillan DC, Elahi MM, Sattar N, Angerson WJ, Johnstone J and McArdle CS: Measurement of the systemic inflammatory response predicts cancer-specific and non-cancer survival in patients with cancer. Nutr Cancer. 41:64–69. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dagg K and Scott HR: A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer. Br J Cancer. 92:1834–1836. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Brown DJ, Milroy R, Preston T and McMillan DC: The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer. J Clin Pathol. 60:705–708. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Glen P, Jamieson NB, McMillan DC, Carter R, Imrie CW and McKay CJ: Evaluation of an inflammation-based prognostic score in patients with inoperable pancreatic cancer. Pancreatology. 6:450–453. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ramsey S, Lamb GW, Aitchison M, Graham J and McMillan DC: Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer. Cancer. 109:205–212. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Omichi C, Nakamura K, Haraga J, Masuyama H and Hiramatsu Y: Glasgow prognostic score is an independent marker for poor prognosis with all cases of epithelial ovarian cancer. Cancer Med. 5:1074–1080. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Zhu J, Wang H, Liu CC, Lu Y and Tang H: The Glasgow Prognostic Score (GPS) is a novel prognostic indicator in advanced epithelial ovarian cancer: A multicenter retrospective study. J Cancer Res Clin Oncol. 142:2339–2345. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Nishida T, Nakamura K, Haraga J, Ogawa C, Kusumoto T, Seki N, Masuyama H, Katayama N, Kanazawa S and Hiramatsu Y: The Glasgow prognostic score determined during concurrent chemoradiotherapy is an independent predictor of survival for cervical cancer. Int J Gynecol Cancer. 25:1306–1314. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Polterauer S, Grimm C, Seebacher V, Rahhal J, Tempfer C, Reinthaller A and Hefler L: The inflammation-based Glasgow prognostic score predicts survival in patients with cervical cancer. Int J Gynecol Cancer. 20:1052–1057. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Kurman RJ, Carcangiu ML, Herrington CS and Young RH: WHO Classification of Tumors of Female Reproductive Organs. Fourth. Lyon, France: IARC Press; pp. 62014

23 

Marnell L, Mold C and Du Clos TW: C-reactive protein: Ligands, receptors and role in inflammation. Clin Immunol. 117:104–111. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Forrest LM, McMillan DC, McArdle CS, Angerson WJ and Dunlop DJ: Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer. 89:1028–1030. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Candido J and Hagemann T: Cancer-related inflammation. J Clin Immunol. 33 Suppl 1:S79–S84. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C and Flavell RA: Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 13:759–771. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, Wan B, Kwak LW, Yu L and Yi Q: Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell. 12:252–265. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Gupta D and Lis CG: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature. Nutr J. 9:692010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nakamura K, Nakayama K, Minamoto T, Ishibashi T, Sanuki K, Yamashita H, Ono R, Sasamori H, Komatsu‑Fujii T, Ishikawa M, Ishikawa M, et al: High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Mol Clin Oncol 8: 429-433, 2018.
APA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H. ... Kyo, S. (2018). High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Molecular and Clinical Oncology, 8, 429-433. https://doi.org/10.3892/mco.2018.1551
MLA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8.3 (2018): 429-433.
Chicago
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8, no. 3 (2018): 429-433. https://doi.org/10.3892/mco.2018.1551
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura K, Nakayama K, Minamoto T, Ishibashi T, Sanuki K, Yamashita H, Ono R, Sasamori H, Komatsu‑Fujii T, Ishikawa M, Ishikawa M, et al: High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Mol Clin Oncol 8: 429-433, 2018.
APA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H. ... Kyo, S. (2018). High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma. Molecular and Clinical Oncology, 8, 429-433. https://doi.org/10.3892/mco.2018.1551
MLA
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8.3 (2018): 429-433.
Chicago
Nakamura, K., Nakayama, K., Minamoto, T., Ishibashi, T., Sanuki, K., Yamashita, H., Ono, R., Sasamori, H., Komatsu‑Fujii, T., Ishikawa, M., Kyo, S."High preoperative Glasgow prognostic score is a negative prognostic factor for patients with endometrial carcinoma". Molecular and Clinical Oncology 8, no. 3 (2018): 429-433. https://doi.org/10.3892/mco.2018.1551
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team