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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-2018 Volume 8 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient

  • Authors:
    • Shaoyu Yang
    • Liming Wu
    • Xin Li
    • Jie Huang
    • Jianbo Zhong
    • Xueqin Chen

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Dermatology, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China
  • Pages: 457-459
    |
    Published online on: January 11, 2018
       https://doi.org/10.3892/mco.2018.1553
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Abstract

Crizotinib is an oral small-molecule inhibitor of anaplastic lymphoma kinase (ALK) tyrosine‑kinase that has been approved for treating patients with advanced echinoderm microtubule associated protein like 4‑ALK rearranged non‑small‑cell lung cancer (NSCLC). Toxic epidermal necrolysis (TEN) is a rare adverse event associated with crizotinib. The present study reported a case of a 75‑year‑old Chinese male patient with advanced NSCLC with ALK fusion, who developed TEN after 56 days of crizotinib treatment and demised due to this dermatological adverse event. The occurrence of severe cutaneous necrolysis that predominantly involves the skin and mucous membranes during crizotinib treatment should alert clinicians to be aware of TEN and take prompt actions.
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Copy and paste a formatted citation
Spandidos Publications style
Yang S, Wu L, Li X, Huang J, Zhong J and Chen X: Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient. Mol Clin Oncol 8: 457-459, 2018.
APA
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., & Chen, X. (2018). Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient. Molecular and Clinical Oncology, 8, 457-459. https://doi.org/10.3892/mco.2018.1553
MLA
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., Chen, X."Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient". Molecular and Clinical Oncology 8.3 (2018): 457-459.
Chicago
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., Chen, X."Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient". Molecular and Clinical Oncology 8, no. 3 (2018): 457-459. https://doi.org/10.3892/mco.2018.1553
Copy and paste a formatted citation
x
Spandidos Publications style
Yang S, Wu L, Li X, Huang J, Zhong J and Chen X: Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient. Mol Clin Oncol 8: 457-459, 2018.
APA
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., & Chen, X. (2018). Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient. Molecular and Clinical Oncology, 8, 457-459. https://doi.org/10.3892/mco.2018.1553
MLA
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., Chen, X."Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient". Molecular and Clinical Oncology 8.3 (2018): 457-459.
Chicago
Yang, S., Wu, L., Li, X., Huang, J., Zhong, J., Chen, X."Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient". Molecular and Clinical Oncology 8, no. 3 (2018): 457-459. https://doi.org/10.3892/mco.2018.1553
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