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Article

MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation

  • Authors:
    • Till J. Meyer
    • Stefan Hartmann
    • Gisela Wohlleben
    • Muna Brisam
    • Axel Seher
    • Alexander C. Kübler
    • Bülent Polat
    • Urs D.A. Müller‑Richter
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Plastic Surgery, University Hospital of Würzburg, D‑97070 Würzburg, Germany, Department of Radiation Oncology, University Hospital of Würzburg, D‑97080 Würzburg, Germany
  • Pages: 513-519
    |
    Published online on: January 19, 2018
       https://doi.org/10.3892/mco.2018.1558
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Abstract

Radiotherapy alone, or as an addition to surgery is important for the treatment of head and neck squamous cell carcinoma (HNSCC). In addition to their expression in germ cells, melanoma associated antigens‑A (MAGE‑A) are only expressed in malignant tissue. Notably, there is a known correlation between MAGE‑A9 expression and poor prognosis in HNSCC patients. However, current knowledge regarding the function of MAGE‑A9 expression, particularly in the context of irradiation, is limited. MAGE‑A9 expression in 37 oral squamous cell carcinoma patents was immunohistochemically determined and analyzed for overall survival by the Kaplan‑Meier log‑rank test. Next, the expression of MAGE‑A9 was determined by reverse transcription‑quantitative polymerase chain reaction in HNSCC cell lines prior to and following irradiation with 2 Gray. The radiosensitivity of each cell line was determined using a clonogenic survival assay. There was a significantly (P=0.0468) longer overall survival in patients with a low level of MAGE‑A9 expression. The median overall survival in patients with high MAGE‑A9 expression was 47% compared to 73% in the group with low MAGE‑A9 expression. The cell lines revealed a distinct expression pattern of MAGE‑A9. Following irradiation of the cell lines, a significant enhancement of MAGE‑A9 mRNA expression levels was observed. The most prominent alteration in MAGE‑A9 expression was observed in the most radioresistant cell line. A high MAGE‑A9 expression level correlates significantly with lower overall survival in HNSCC patients. Additionally, irradiation increased the MAGE‑A9 mRNA levels in all five HNSCC cell lines, and the most resistant cell line demonstrated the greatest increase in MAGE‑A9 expression following irradiation.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Gupta S, Kong W, Peng Y, Miao Q and Mackillop WJ: Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States. Int J Cancer. 125:2159–2165. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Pulte D and Brenner H: Changes in survival in head and neck cancers in the late 20th and early 21st century: A period analysis. Oncologist. 15:994–1001. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Fakhry C, Westra WH, Li S, Cmelak A, Ridge JA, Pinto H, Forastiere A and Gillison ML: Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 100:261–269. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Zelefsky MJ, Harrison LB, Fass DE, Armstrong JG, Shah JP and Strong EW: Postoperative radiation therapy for squamous cell carcinomas of the oral cavity and oropharynx: Impact of therapy on patients with positive surgical margins. Int J Radiat Oncol Biol Phys. 25:17–21. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Adelstein DJ, Li Y, Adams GL, Wagner H Jr, Kish JA, Ensley JF, Schuller DE and Forastiere AA: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 21:92–98. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Scanlan MJ, Simpson AJ and Old LJ: The cancer/testis genes: Review, standardization, and commentary. Cancer Immun. 4:12004.PubMed/NCBI

8 

Sang M, Lian Y, Zhou X and Shan B: MAGE-A family: Attractive targets for cancer immunotherapy. Vaccine. 29:8496–8500. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Scanlan MJ, Gure AO, Jungbluth AA, Old LJ and Chen YT: Cancer/testis antigens: An expanding family of targets for cancer immunotherapy. Immunol Rev. 188:22–32. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Atanackovic D, Altorki NK, Stockert E, Williamson B, Jungbluth AA, Ritter E, Santiago D, Ferrara CA, Matsuo M, Selvakumar A, et al: Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients. J Immunol. 172:3289–3296. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Müller-Richter UD, Dowejko A, Zhou W, Reichert TE and Driemel O: Different expression of MAGE-A-antigens in foetal and adult keratinocyte cell lines. Oral Oncol. 44:628–633. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Sang M, Wang L, Ding C, Zhou X, Wang B, Wang L, Lian Y and Shan B: Melanoma-associated antigen genes-an update. Cancer Lett. 302:85–90. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Krauss E, Rauthe S, Gattenlöhner S, Reuther T, Kochel M, Kriegebaum U, Kübler AC and Müller-Richter UD: MAGE-A antigens in lesions of the oral mucosa. Clin Oral Investig. 15:315–320. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Laban S, Giebel G, Klümper N, Schröck A, Doescher J, Spagnoli G, Thierauf J, Theodoraki MN, Remark R, Gnjatic S, et al: MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. Oncotarget. 8:14719–14735. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Laban S, Atanackovic D, Luetkens T, Knecht R, Busch CJ, Freytag M, Spagnoli G, Ritter G, Hoffmann TK, Knuth A, et al: Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer. Int J Cancer. 135:1142–1152. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Cuffel C, Rivals JP, Zaugg Y, Salvi S, Seelentag W, Speiser DE, Liénard D, Monnier P, Romero P, Bron L and Rimoldi D: Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma. Int J Cancer. 128:2625–2634. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Hartmann S, Meyer TJ, Brands RC, Haubitz IR, Linz C, Seher A, Kübler AC and Müller-Richter UD: MAGE-A expression clusters and antineoplastic treatment in head and neck cancer. Int J Mol Med. 35:1675–1682. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Hartmann S, Kriegebaum U, Küchler N, Brands RC, Linz C, Kübler AC and Müller-Richter UD: Correlation of MAGE-A tumor antigens and the efficacy of various chemotherapeutic agents in head and neck carcinoma cells. Clin Oral Investig. 18:189–197. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hartmann S, Kriegebaum U, Küchler N, Lessner G, Brands RC, Linz C, Schneider T, Kübler AC and Müller-Richter UD: Efficacy of cetuximab and panitumumab in oral squamous cell carcinoma cell lines: Prognostic value of MAGE-A subgroups for treatment success. J Craniomaxillofac Surg. 41:623–629. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Han L, Jiang B, Wu H, Zhang S and Lu X: Expression and prognostic value of MAGE-A9 in laryngeal squamous cell carcinoma. Int J Clin Exp Pathol. 7:6734–6742. 2014.PubMed/NCBI

21 

Gu X, Fu M, Ge Z, Zhan F, Ding Y, Ni H, Zhang W, Zhu Y, Tang X, Xiong L, et al: High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma. Sci Rep. 4:66252014. View Article : Google Scholar : PubMed/NCBI

22 

Hatiboglu G, Pritsch M, Macher-Goeppinger S, Zöller M, Huber J, Haferkamp A, Pahernik S, Wagener N and Hohenfellner M: Prognostic value of melanoma-associated antigen A9 in renal cell carcinoma. Scand J Urol. 47:311–322. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Xu X, Tang X, Lu M, Tang Q, Zhang H, Zhu H, Xu N, Zhang D, Xiong L, Mao Y and Zhu J: Overexpression of MAGE-A9 predicts unfavorable outcome in breast cancer. Exp Mol Pathol. 97:579–584. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Xu Y, Wang C, Zhang Y, Jia L and Huang J: Overexpression of MAGE-A9 is predictive of poor prognosis in epithelial ovarian cancer. Sci Rep. 5:121042015. View Article : Google Scholar : PubMed/NCBI

25 

Zhai X, Xu L, Zhang S, Zhu H, Mao G and Huang J: High expression levels of MAGE-A9 are correlated with unfavorable survival in lung adenocarcinoma. Oncotarget. 7:4871–4881. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhan W, Zhang Z, Zhang Y, Ma J, Wu T, Gu Y, Li Y and Yang J: Prognostic value of MAGE-A9 expression in patients with colorectal cancer. Clin Res Hepatol Gastroenterol. 40:239–245. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Remmele W and Stegner HE: Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 8:138–140. 1987.(In German). PubMed/NCBI

28 

Heo DS, Snyderman C, Gollin SM, Pan S, Walker E, Deka R, Barnes EL, Johnson JT, Herberman RB and Whiteside TL: Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines. Cancer Res. 49:5167–5175. 1989.PubMed/NCBI

29 

Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 350:1937–1944. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, et al: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 350:1945–1952. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Figueiredo DL, Mamede RC, Proto-Siqueira R, Neder L, Silva WA Jr and Zago MA: Expression of cancer testis antigens in head and neck squamous cell carcinomas. Head Neck. 28:614–619. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Kerkar SP, Wang ZF, Lasota J, Park T, Patel K, Groh E, Rosenberg SA and Miettinen MM: MAGE-A is more highly expressed than NY-ESO-1 in a systematic immunohistochemical analysis of 3668 cases. J Immunother. 39:181–187. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Lee KD, Lee HS, Kim SW, Park T, Hong JC, Chang HK, Jung SB, Jeon CH and Park JW: Clinical significance of melanoma-associated antigen A1-6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx. Head Neck. 38 Suppl 1:E736–E740. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Ries J, Agaimy A, Vairaktaris E, Kwon Y, Neukam FW, Strassburg LH and Nkenke E: Evaluation of MAGE-A expression and grade of dysplasia for predicting malignant progression of oral leukoplakia. Int J Oncol. 41:1085–1093. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Marcar L, Maclaine NJ, Hupp TR and Meek DW: Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin. Cancer Res. 70:10362–10370. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Monte M, Simonatto M, Peche LY, Bublik DR, Gobessi S, Pierotti MA, Rodolfo M and Schneider C: MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. Proc Natl Acad Sci USA. 103:pp. 11160–11165. 2006; View Article : Google Scholar : PubMed/NCBI

37 

Yang B, Oherrin SM, Wu J, Reagan-Shaw S, Ma Y, Bhat KM, Gravekamp C, Setaluri V, Peters N, Hoffmann FM, et al: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. Cancer Res. 67:9954–9962. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Hartmann S, Zwick L, Scheurer MJJ, Fuchs AR, Brands RC, Seher A, Böhm H, Kübler AC and Müller-Richter UDA: MAGE-A11 expression contributes to cisplatin resistance in head and neck cancer. Clin Oral Investig. Oct 15–2017.(Epub ahead of print). View Article : Google Scholar

39 

Picard V, Bergeron A, Larue H and Fradet Y: MAGE-A9 mRNA and protein expression in bladder cancer. Int J Cancer. 120:2170–2177. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Wischnewski F, Pantel K and Schwarzenbach H: Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res. 4:339–349. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Cacan E, Greer SF and Garnett-Benson C: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. Int J Oncol. 47:2264–2275. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

43 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Yan Y, Hein AL, Etekpo A, Burchett KM, Lin C, Enke CA, Batra SK, Cowan KH and Ouellette MM: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation. Oncotarget. 5:10251–10270. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Skvortsov S, Jimenez CR, Knol JC, Eichberger P, Schiestl B, Debbage P, Skvortsova I and Lukas P: Radioresistant head and neck squamous cell carcinoma cells: Intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets. Radiother Oncol. 101:177–182. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Skvortsov S, Dudás J, Eichberger P, Witsch-Baumgartner M, Loeffler-Ragg J, Pritz C, Schartinger VH, Maier H, Hall J, Debbage P, et al: Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC). Br J Cancer. 110:2677–2687. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meyer TJ, Hartmann S, Wohlleben G, Brisam M, Seher A, Kübler AC, Polat B and Müller‑Richter UD: MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. Mol Clin Oncol 8: 513-519, 2018.
APA
Meyer, T.J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A.C. ... Müller‑Richter, U.D. (2018). MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. Molecular and Clinical Oncology, 8, 513-519. https://doi.org/10.3892/mco.2018.1558
MLA
Meyer, T. J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A. C., Polat, B., Müller‑Richter, U. D."MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation". Molecular and Clinical Oncology 8.3 (2018): 513-519.
Chicago
Meyer, T. J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A. C., Polat, B., Müller‑Richter, U. D."MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation". Molecular and Clinical Oncology 8, no. 3 (2018): 513-519. https://doi.org/10.3892/mco.2018.1558
Copy and paste a formatted citation
x
Spandidos Publications style
Meyer TJ, Hartmann S, Wohlleben G, Brisam M, Seher A, Kübler AC, Polat B and Müller‑Richter UD: MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. Mol Clin Oncol 8: 513-519, 2018.
APA
Meyer, T.J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A.C. ... Müller‑Richter, U.D. (2018). MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation. Molecular and Clinical Oncology, 8, 513-519. https://doi.org/10.3892/mco.2018.1558
MLA
Meyer, T. J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A. C., Polat, B., Müller‑Richter, U. D."MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation". Molecular and Clinical Oncology 8.3 (2018): 513-519.
Chicago
Meyer, T. J., Hartmann, S., Wohlleben, G., Brisam, M., Seher, A., Kübler, A. C., Polat, B., Müller‑Richter, U. D."MAGE-A9 in head and neck cancer: Prognostic value and preclinical findings in the context of irradiation". Molecular and Clinical Oncology 8, no. 3 (2018): 513-519. https://doi.org/10.3892/mco.2018.1558
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