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Article

Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome

  • Authors:
    • Munveer S. Bhangoo
    • Brian Cheng
    • Gregory P. Botta
    • Phataraporn Thorson
    • Michael P. Kosty
  • View Affiliations / Copyright

    Affiliations: Division of Hematology‑Oncology, Scripps Clinic, La Jolla, CA 92037, USA, Department of Internal Medicine, Scripps Clinic, La Jolla, CA 92037, USA, Department of Pathology, Scripps Clinic, La Jolla, CA 92037, USA
  • Pages: 609-612
    |
    Published online on: February 2, 2018
       https://doi.org/10.3892/mco.2018.1564
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Abstract

As with other genitourinary malignancies, a variety of paraneoplastic syndromes have been revealed to occur in patients with prostate cancer. Stauffer's Syndrome is a well‑described clinical syndrome which manifests via intrahepatic cholestasis in patients with renal cell carcinoma. Less common is intrahepatic cholestasis occurring in association with prostate cancer. The current case report discusses a 67‑year‑old man presenting with liver failure secondary to intrahepatic cholestasis co‑existing with metastatic prostate adenocarcinoma. The patient's liver failure completely resolved with androgen‑deprivation therapy suggesting an association between these two entities. The case report evaluates existing literature on this uncommon syndrome including the clinical presentation, natural history, and potential pathophysiology.
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Copy and paste a formatted citation
Spandidos Publications style
Bhangoo MS, Cheng B, Botta GP, Thorson P and Kosty MP: Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. Mol Clin Oncol 8: 609-612, 2018.
APA
Bhangoo, M.S., Cheng, B., Botta, G.P., Thorson, P., & Kosty, M.P. (2018). Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. Molecular and Clinical Oncology, 8, 609-612. https://doi.org/10.3892/mco.2018.1564
MLA
Bhangoo, M. S., Cheng, B., Botta, G. P., Thorson, P., Kosty, M. P."Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome". Molecular and Clinical Oncology 8.4 (2018): 609-612.
Chicago
Bhangoo, M. S., Cheng, B., Botta, G. P., Thorson, P., Kosty, M. P."Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome". Molecular and Clinical Oncology 8, no. 4 (2018): 609-612. https://doi.org/10.3892/mco.2018.1564
Copy and paste a formatted citation
x
Spandidos Publications style
Bhangoo MS, Cheng B, Botta GP, Thorson P and Kosty MP: Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. Mol Clin Oncol 8: 609-612, 2018.
APA
Bhangoo, M.S., Cheng, B., Botta, G.P., Thorson, P., & Kosty, M.P. (2018). Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome. Molecular and Clinical Oncology, 8, 609-612. https://doi.org/10.3892/mco.2018.1564
MLA
Bhangoo, M. S., Cheng, B., Botta, G. P., Thorson, P., Kosty, M. P."Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome". Molecular and Clinical Oncology 8.4 (2018): 609-612.
Chicago
Bhangoo, M. S., Cheng, B., Botta, G. P., Thorson, P., Kosty, M. P."Reversible intrahepatic cholestasis in metastatic prostate cancer: An uncommon paraneoplastic syndrome". Molecular and Clinical Oncology 8, no. 4 (2018): 609-612. https://doi.org/10.3892/mco.2018.1564
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