A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

Nitipir,Cornelia; Ginghina,Octav; Popa,Liliana; Andrei,Florin; Tudor,Nicolaie; Radu,Irina; Iaciu,Cristian; Orlov,Cristina; Vasilescu,Florina; Balalau,Cristian; Leon,Grigoris; Negrei,Carolina; Barbu,Maria  Alexandra

doi:10.3892/mco.2018.1565

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Article

A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

Authors:
- Cornelia Nitipir
- Octav Ginghina
- Liliana Popa
- Florin Andrei
- Nicolaie Tudor
- Irina Radu
- Cristian Iaciu
- Cristina Orlov
- Florina Vasilescu
- Cristian Balalau
- Grigoris Leon
- Carolina Negrei
- Maria Alexandra Barbu
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Affiliations: Department of Oncology, Elias University Clinical Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 011461 Bucharest, Romania, Department of Surgery, ‘Sf. Ioan’ Clinical Emergency Hospital, Carol Davila University, Faculty of Dental Medicine, 042122 Bucharest, Romania, Department of Dermatology, Elias University Clinical Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 011461 Bucharest, Romania, Department of Histopathology, Elias University Clinical Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 011461 Bucharest, Romania, Department of Gastroenterology, Elias University Clinical Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 011461 Bucharest, Romania, Department of Pathology, Emergency University Military Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 020021 Bucharest, Romania, Department of Surgery, ‘Sf. Pantelimon’ Clinical Emergency Hospital, Carol Davila University, Medicine and Pharmacy Faculty, 021659 Bucharest, Romania, Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, 10679 Athens, Greece, Department of Toxicology, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania
Pages: 595-599
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Published online on: February 2, 2018

https://doi.org/10.3892/mco.2018.1565
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Abstract

Although gastric metastases have been estimated to occur in less than 2% of cancer patients, an increased use of upper digestive tract endoscopy allows for a higher detection of secondary gastric tumors. We describe the case of a 66-year-old male patient presenting with mild pain in the sternum and upper abdominal area. Physical examination revealed a right parietal skull tumor, with no other significant clinical changes. Upon exclusion of an acute coronary syndrome, upper digestive tract endoscopy was performed, showing the presence of an ulcerated tumor located in the gastric fundus. Histopathologic examination of the biopsy sample and immunohistochemical tests suggested a pulmonary origin of the gastric tumor. Whole body computer tomography showed the presence of tumors in the gastric fundus, left lung, liver, kidneys, bones and brain. Transbronchial biopsy of the lung tumor certified the diagnosis of non-small cell lung cancer, with the same immunohistochemical profile as the gastric tumor. Hence, it was considered the origin of the metastases. Biopsy of the skull tumor also had the identical tumor histology. Whole brain radiotherapy was performed for the brain metastases and subsequent chemotherapy was administered. Although non-specific, gastrointestinal signs and symptoms occurring in lung cancer patients should alert the clinicians as to the possibility of gastrointestinal metastases and prompt endoscopic evaluation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

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