Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma, accompanied with lymph node metastasis

Namikawa,Tsutomu; Fujisawa,Kazune; Munekage,Eri; Munekage,Masaya; Oki,Yusuke; Maeda,Hiromichi; Kitagawa,Hiroyuki; Ueta,Hiroshi; Kobayashi,Michiya; Hanazaki,Kazuhiro

doi:10.3892/mco.2018.1567

April-2018 Volume 8 Issue 4

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April-2018 Volume 8 Issue 4

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Article

Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma, accompanied with lymph node metastasis

Authors:
- Tsutomu Namikawa
- Kazune Fujisawa
- Eri Munekage
- Masaya Munekage
- Yusuke Oki
- Hiromichi Maeda
- Hiroyuki Kitagawa
- Hiroshi Ueta
- Michiya Kobayashi
- Kazuhiro Hanazaki
View Affiliations / Copyright

Affiliations: Department of Surgery, Kochi Medical School, Kochi 783‑8505, Japan, Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi 783‑8505, Japan, Cancer Treatment Center, Kochi Medical School Hospital, Kochi 783‑8505, Japan, Department of Gastroenterology and Hepatology, Kochi Prefectural Hata Kenmin Hospital, Kochi 783‑8505, Japan
Pages: 557-560
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Published online on: February 5, 2018

https://doi.org/10.3892/mco.2018.1567
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Abstract

The present case report presents a rare case of Epstein‑Barr virus (EBV)‑associated early gastric carcinoma with lymphoid stroma, accompanied by lymph node metastasis. A 61‑year‑old woman was referred to our hospital following observation of a gastric mass lesion that was initially diagnosed at a medical check‑up. Esophagogastroduodenoscopy revealed a slightly elevated lesion with a central irregular depression in the middle third of the stomach. Endoscopic ultrasonography revealed a well‑circumscribed hypoechoic mass located predominantly within the submucosa and the mucosa. Biopsy specimens of the lesion indicated the possibility of carcinoma with lymphoid stroma with a lymphoepithelial lesion. Abdominal contrast‑enhanced computed tomography (CT) revealed a well‑defined mass with homogeneous enhancement approximately 1.2 cm in diameter in the middle part of the stomach, demonstrating lymphadenopathy in the perigastric area at a maximum size of 1.4 cm in diameter. The patient underwent laparoscopic distal gastrectomy with regional lymphadenectomy due to suspicion of a gastric carcinoma with lymphoid stroma. Histopathological and immunohistochemical findings verified the diagnosis of carcinoma with lymphoid stroma, which were positive for EBV‑encoded RNA (EBER‑ISH) by in situ hybridization. There was one lymph node metastasis, which was in line with the CT imaging. Marked infiltration of lymphoid cells was observed in the tumor stroma, which were negative for EBER‑ISH. The present case is informative of the pathological characteristics of this condition, and clinicians should recognize the features of this disease to make an accurate diagnosis and select the appropriate treatment.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma, accompanied with lymph node metastasis

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Abstract

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