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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2018 Volume 8 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Review

Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review)

  • Authors:
    • Qi-Bing Wu
    • Xin Sheng
    • Ning Zhang
    • Ming-Wei Yang
    • Fan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
  • Pages: 523-527
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/mco.2018.1578
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Abstract

Colorectal cancer (CRC) is among the main tumor-related causes of death worldwide. The fact that the majority of the patients develop resistance to chemoradiotherapy (CRT) is a major obstacle for the treatment of CRC. In order to develop more effective treatment strategies, it is crucial to elucidate the mechanisms underlying the development of resistance to CRT. Several studies have recently indicated the regulatory effects of microRNAs (miRNAs) in response to antitumor agents. For example, miR-34a attenuates the chemoresistance of colon cancer to 5-FU by inhibiting E2F3 and SIRT1. The miR-34a mimic MRX34 is the first synthetic miRNA to have been entered into clinical trials. miR-21 prevents tumor cell stemness, invasion and drug resistance, which are required for the development of CRC. These findings suggest that miRNAs represent a focus in the research of novel cancer treatments aimed at sensitizing cancer cells to chemotherapeutic drugs. The aim of the present study was to review the functions of miRNAs and investigate the roles of miRNAs in CRC radioresistance or chemoresistance. Furthermore, the potential of including miRNAs in therapeutic strategies and using them as molecular biomarkers for predicting radiosensitivity and chemosensitivity was discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Q, Sheng X, Zhang N, Yang M and Wang F: Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review). Mol Clin Oncol 8: 523-527, 2018.
APA
Wu, Q., Sheng, X., Zhang, N., Yang, M., & Wang, F. (2018). Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review). Molecular and Clinical Oncology, 8, 523-527. https://doi.org/10.3892/mco.2018.1578
MLA
Wu, Q., Sheng, X., Zhang, N., Yang, M., Wang, F."Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review)". Molecular and Clinical Oncology 8.4 (2018): 523-527.
Chicago
Wu, Q., Sheng, X., Zhang, N., Yang, M., Wang, F."Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review)". Molecular and Clinical Oncology 8, no. 4 (2018): 523-527. https://doi.org/10.3892/mco.2018.1578
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Q, Sheng X, Zhang N, Yang M and Wang F: Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review). Mol Clin Oncol 8: 523-527, 2018.
APA
Wu, Q., Sheng, X., Zhang, N., Yang, M., & Wang, F. (2018). Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review). Molecular and Clinical Oncology, 8, 523-527. https://doi.org/10.3892/mco.2018.1578
MLA
Wu, Q., Sheng, X., Zhang, N., Yang, M., Wang, F."Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review)". Molecular and Clinical Oncology 8.4 (2018): 523-527.
Chicago
Wu, Q., Sheng, X., Zhang, N., Yang, M., Wang, F."Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy (Review)". Molecular and Clinical Oncology 8, no. 4 (2018): 523-527. https://doi.org/10.3892/mco.2018.1578
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