Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
April-2018 Volume 8 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 8 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer

  • Authors:
    • Hidehiro Tajima
    • Mitsuyoshi Okazaki
    • Takahisa Yamaguchi
    • Yoshinao Ohbatake
    • Koichi Okamoto
    • Shinichi Nakanuma
    • Shiro Terai
    • Seisho Sakai
    • Jun Kinoshita
    • Isamu Makino
    • Keishi Nakamura
    • Hironori Hayashi
    • Katsunobu Oyama
    • Masafumi Inokuchi
    • Tomoharu Miyashita
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Sachio Fushida
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan
  • Pages: 623-627
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/mco.2018.1579
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognosis of patients with unresectable or recurrent pancreatic cancers is very poor. Prior to development of nab-paclitaxel (PTX) plus gemcitabine (GEM) therapy and FOLFIRINOX therapy, there was no recommended third-line chemotherapy after 5-fluorouracil (5-FU) and GEM-based regimens. The present study conducted a Phase I clinical trial of weekly low-dose PTX as a third-line palliative chemotherapy for patients with pancreatic cancer. PTX was administered on days 1, 8, 15, and 22 of each cycle, repeated twice as follows: Level 1, 40 mg/m2 (n=6); Level 2, 50 mg/m2 (n=4). During the two cycles, three patients developed Grade 3 neutropenia in level 2; thus, the recommended dose was defined as 40 mg/m2. The disease control rate was 40.0% (stable disease, n=4). Median time to treatment failure of the four patients with stable disease was 5.5 months. In conclusion, palliative chemotherapy with low-dose PTX after failure of GEM and 5-FU is well tolerated and safe for unresectable or recurrent pancreatic cancer patients. The unique ID issues by UMIN: 000008148.
View Figures

Figure 1

Figure 2

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Keys HM, Bundy BN, Stehamn FB, Muderspach LI, Chafe WE, Suggs CL III, Walker JL and Gersell D: Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med. 340:1154–1161. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Morris M, Eifel PJ, Lu J, Grigsby PW, Levenback C, Stevens RE, Rotman M, Gershenson DM and Mutch DG: Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer. N Engl J Med. 340:1137–1143. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Whitney CW, Sause W, Bundy BN, Malfetano JH, Hannigan EV, Fowler WC Jr, Clarke-Pearson DL and Liao SY: Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stages IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes. A Gynecologic Oncology Group and Southwest Oncology Group Study. J Clin Oncol. 17:1339–1348. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, Clarke-Pearson DL and Insalaco S: Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 340:1144–1153. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Peters WA III, Liu PY, Barrett RJ II, Stock RJ, Monk BJ, Berek JS, Souhami L, Grigsby P, Gordon W Jr and Alberts DS: Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 18:1606–1613. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Pearcey R, Brundage M, Drouin P, Jeffrey J, Johnston D, Lukka H, MacLean G, Souhami L, Stuart G and Tu D: Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol. 20:966–972. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Ferrandina G, Legge F, Fagotti A, Fanfani F, Distefano M, Morganti A, Cellini N and Scambia G: Preoperative concomitant chemoradiotherapy in locally advanced cervical cancer: Safety, outcome and prognostic measures. Gynecol Oncol. 107 1 Suppl 1:S127–S132. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Ngô C, Alran S, Plancher C, Fourchotte V, Petrow P, Campitelli M, Batwa S, Sastre X, Salmon RJ and de la Rochefordière A; Institut Curie Gynaecological Cancer Study Group coordinated by P. Cottu, : Outcome in early cervical cancer following pre-operative low dose rate brachytherapy: A ten-year follow up of 257 patients treated at a single institution. Gynecol Oncol. 123:248–252. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ferrandina G, Margariti PA, Smaniotto D, Petrillo M, Salerno MG, Fagotti A, Macchia G, Morganti AG, Cellini N and Scambia G: Long-term analysis of clinical outcome and complications in locally advanced cervical cancer patients administered concomitant chemoradiation followed by radical surgery. Gynecol Oncol. 119:404–410. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Classe JM, Rauch P, Rodier JF, Morice P, Stoeckle E, Lasry S and Houvenaeghel G; Groupe des Chirurgiens de Centre de Lutte Contre le Cancer (GCCLCC), : Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: Morbidity and outcome: Results of a multicenter study of the GCCLCC. Gynecol Oncol. 102:523–529. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Benedet JL, Bender H, Jones H 3rd, Ngan HY and Pecorelli S: FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology. Int J Gynaecol Obstet. 70:209–262. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Resbeut M, Cowen D, Viens P, Noirclerc M, Perez T, Gouvernet J, Delpero JR, Gamerre M, Boubli L and Houvenaeghel G: Concomitant chemoradiation prior to surgery in the treatment of advanced cervical carcinoma. Gynecol Oncol. 54:68–75. 1994. View Article : Google Scholar : PubMed/NCBI

14 

Jurado M, Martínez-Monge R, García-Foncillas J, Azinovic I, Aristu J, López-García G and Brugarolas A: Pilot study of concurrent cisplatin, 5-fluorouracil, and external beam radiotherapy prior to radical surgery +/− intraoperative electron beam radiotherapy in locally advanced cervical cancer. Gynecol Oncol. 74:30–37. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Mancuso S, Smaniotto D, Benedetti Panici P, Favale B, Greggi S, Manfredi R, Margariti PA, Morganti AG, Scambia G, Tortoreto F, et al: Phase I–II trial of preoperative chemoradiation in locally advanced cervical carcinoma. Gynecol Oncol. 78:324–328. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Distefano M, Ferrandina G, Smaniotto D, Margariti AP, Zannoni G, Macchia G, Manfredi R, Mangiacotti MG, Cellini N and Scambia G: Concomitant radiochemotherapy plus surgery in locally advanced cervical cancer: Update of clinical outcome and cyclooxygenase-2 as predictor of treatment susceptibility. Oncology. 67:103–111. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Mariagrazia D, Anna F, Gabriella F, Francesco F, Daniela S, Giuseppe D, Alessio M and Giovanni S: Preoperative chemoradiotherapy in locally advanced cervical cancer: Long-term outcome and complications. Gynecol Oncol. 99 3 Suppl 1:S166–S170. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Motton S, Houvenaeghel G, Delannes M, Querleu D, Soulé-Tholy M, Hoff J and Lèguevaque P: Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: Comparison of extended hysterectomy and extrafascial hysterectomy. Int J Gynecol Cancer. 20:268–275. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Touboul C, Uzan C, Mauguen A, Gouy S, Rey A, Pautier P, Lhommé C, Duvillard P, Haie-Meder C and Morice P: Prognostic factors and morbidities after completion surgery in patients undergoing initial chemoradiation therapy for locally advanced cervical cancer. Oncologist. 15:405–415. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Quinn MA, Benedet JL, Odicino F, et al: Carcinoma of the cervix uteri. FIGO 26th annual report on the results of treatment in gynaecological cancer. Int J Gynaecol Obstet. 95:S43–S103. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M and Williams CJ: Survival and recurrence after concurrent chemotherapy and radiotherapy for cancer of the uterine cervix: A systematic review and meta-analysis. Lancet. 358:781–786. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, Favini G, Ferri L and Mangioni C: Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 350:535–540. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Keys HM, Bundy BN, Stehman FB, Muderspach LI, Chafe WE, Suggs CL III, Walker JL and Gersell D: Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical cancer. N Engl J Med. 340:1154–1161. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Houvenaeghel G, Lelievre L, Gonzague-Casabianca L, Buttarelli M, Moutardier V, Goncalves A and Resbeut M: Long-term survival after concomitant chemoradiotherapy prior to surgery in advanced cervical carcinoma. Gynecol Oncol. 100:338–343. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Dueñas-Gonzalez A, Cetina L, Mariscal I and de la Garza J: Modern management of locally advanced cervical cancer. Cancer Treat Rev. 29:389–399. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Moore DH: Treatment of stage IB2 (bulky) cervical carcinoma. Cancer Treat Rev. 29:401–406. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Rydzewska L, Tierney J, Vale CL and Symonds PR: Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database Syst Rev: CD007406. 2010. View Article : Google Scholar

28 

Nori D, Dasari N and Allbright RM: Gynecologic brachytherapy I: Proper incorporation of brachytherapy into the current multimodality management of carcinoma of the cervix. Semin Radiat Oncol. 12:40–52. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Nag S, Chao C, Erickson B, Fowler J, Gupta N, Martinez A and Thomadsen B; American Brachytherapy Society, : The American Brachytherapy Society for low-dose-rate brachytherapy for carcinoma of the cervix. Int J Radiat Oncol Biol Phys. 52:33–48. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Logsdon MD and Eifel PJ: Figo IIIB squamous cell carcinoma of the cervix: An analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy. Int J Radiat Oncol Biol Phys. 43:763–775. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Hu JL, Wu LY, Li N, Li XG, Huang MN and Zhang R: Comparative analysis of neoadjuvant therapies in stage Ib2 and IIa2 cervical carcinoma. Chin J Obstet Gynecol. 47:452–457. 2012.(In Chinese).

32 

Keys HM, Bundy BN, Stehman FB, Okagaki T, Gallup DG, Burnett AF, Rotman MZ and Fowler WC Jr; Gynecologic Oncology Group, : Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: A randomized trial of the Gynecologic Oncology Group. Gynecol Oncol. 89:343–353. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Houvenaeghel G, Lelievre L, Buttarelli M, Jacquemier J, Carcopino X, Viens P and Gonzague-Casabianca L: Contribution of surgery in patientswith bulky residual disease after chemoradiation for advanced cervical carcinoma. Eur J Surg Oncol. 33:498–503. 2007. View Article : Google Scholar : PubMed/NCBI

34 

de la Rochefordiere A, Kirova Y, Alran S, et al: Pre-operative concomitant radio-chemotherapy in Bulky carcinoma of the cervix: a single institution study. Clin Med Oncol. 2:227–236. 2008.PubMed/NCBI

35 

Pearcey RG, Peel KR, Thorogood J, et al: The value of pre-operative intracavitary radiotherapy in patients treated by radical hysterectomy and pelvic lymphadenectomy for invasive carcinoma of the cervix. Clin Radiol. 39:95–98. 1988. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tajima H, Okazaki M, Yamaguchi T, Ohbatake Y, Okamoto K, Nakanuma S, Terai S, Sakai S, Kinoshita J, Makino I, Makino I, et al: Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer. Mol Clin Oncol 8: 623-627, 2018.
APA
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S. ... Ohta, T. (2018). Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer. Molecular and Clinical Oncology, 8, 623-627. https://doi.org/10.3892/mco.2018.1579
MLA
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S., Terai, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Miyashita, T., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer". Molecular and Clinical Oncology 8.4 (2018): 623-627.
Chicago
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S., Terai, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Miyashita, T., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer". Molecular and Clinical Oncology 8, no. 4 (2018): 623-627. https://doi.org/10.3892/mco.2018.1579
Copy and paste a formatted citation
x
Spandidos Publications style
Tajima H, Okazaki M, Yamaguchi T, Ohbatake Y, Okamoto K, Nakanuma S, Terai S, Sakai S, Kinoshita J, Makino I, Makino I, et al: Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer. Mol Clin Oncol 8: 623-627, 2018.
APA
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S. ... Ohta, T. (2018). Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer. Molecular and Clinical Oncology, 8, 623-627. https://doi.org/10.3892/mco.2018.1579
MLA
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S., Terai, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Miyashita, T., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer". Molecular and Clinical Oncology 8.4 (2018): 623-627.
Chicago
Tajima, H., Okazaki, M., Yamaguchi, T., Ohbatake, Y., Okamoto, K., Nakanuma, S., Terai, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Miyashita, T., Takamura, H., Ninomiya, I., Fushida, S., Ohta, T."Phase I study of third-line palliative chemotherapy with low dose paclitaxel for pancreatic cancer". Molecular and Clinical Oncology 8, no. 4 (2018): 623-627. https://doi.org/10.3892/mco.2018.1579
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team