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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2018 Volume 8 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

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International Journal of Epigenetics

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Case Report

Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report

  • Authors:
    • Amir Sonnenblick
    • Aviad Zick
    • Myriam Maoz
    • Sherri Cohen
    • Luna Kadouri
    • Tamar Peretz
    • Ayala Hubert
  • View Affiliations

    Affiliations: Sharett Institute of Oncology, Hadassah‑Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
  • Published online on: March 9, 2018     https://doi.org/10.3892/mco.2018.1588
  • Pages: 683-685
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Abstract

Tumor genome sequencing is important for increasing our understanding of the development of cancer, which may be affected by different therapies. In the present study, genomic evolution was investigated in a patient with stage IV pancreatic cancer bearing a germline breast cancer 2 (BRCA2) mutation. The patient received cisplatin, a DNA cross-linking agent, which led to a long‑lasting complete response. Eventually the patient developed brain metastasis, suggesting the acquisition of resistance to cisplatin. He subsequently underwent brain lesion resection, radiofrequency ablation and chemotherapy, again resulting in long‑lasting response. Samples of blood, pancreatic tumor tissue and brain metastases were collected and the extracted DNA was sequenced. The pancreatic and brain lesions, when compared with the blood samples, exhibited mutations in the BRCA1 and checkpoint kinase 2 genes, in addition to the germline BRCA2 mutation. The brain lesion, when compared with the primary tumor, harbored no additional mutations or copy‑number variations. These findings suggest that the isolated relapse in the brain was due to pharmacological sanctuary rather than genomic alterations. It may be suggested that the presence of defects in the homologous recombination repair pathways are associated with a good prognosis and clinical sensitivity to agents that damage the DNA in pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Sonnenblick A, Zick A, Maoz M, Cohen S, Kadouri L, Peretz T and Hubert A: Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report. Mol Clin Oncol 8: 683-685, 2018.
APA
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., & Hubert, A. (2018). Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report. Molecular and Clinical Oncology, 8, 683-685. https://doi.org/10.3892/mco.2018.1588
MLA
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., Hubert, A."Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report". Molecular and Clinical Oncology 8.5 (2018): 683-685.
Chicago
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., Hubert, A."Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report". Molecular and Clinical Oncology 8, no. 5 (2018): 683-685. https://doi.org/10.3892/mco.2018.1588
Copy and paste a formatted citation
x
Spandidos Publications style
Sonnenblick A, Zick A, Maoz M, Cohen S, Kadouri L, Peretz T and Hubert A: Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report. Mol Clin Oncol 8: 683-685, 2018.
APA
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., & Hubert, A. (2018). Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report. Molecular and Clinical Oncology, 8, 683-685. https://doi.org/10.3892/mco.2018.1588
MLA
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., Hubert, A."Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report". Molecular and Clinical Oncology 8.5 (2018): 683-685.
Chicago
Sonnenblick, A., Zick, A., Maoz, M., Cohen, S., Kadouri, L., Peretz, T., Hubert, A."Defects in homologous recombination repair genes are associated with good prognosis and clinical sensitivity to DNA-damaging agents in pancreatic cancer: A case report". Molecular and Clinical Oncology 8, no. 5 (2018): 683-685. https://doi.org/10.3892/mco.2018.1588
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