|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Coghlin C and Murray GI: Current and
emerging concepts in tumour metastasis. J Pathol. 222:1–15. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Low WHH, Seet W, A S R, Ng KK, H J, Dan
SP, Teng CL, Lee VKM, Chua SS, My FA, et al: Community-based
cardiovascular Risk Factors Intervention Strategies (CORFIS) in
managing hypertension: A pragmatic non-randomised controlled trial.
Med J Malaysia. 68:129–135. 2013.PubMed/NCBI
|
|
4
|
Zeisberg M and Neilson EG: Biomarkers for
epithelial-mesenchymal transitions. J Clin Invest. 119:1429–1437.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lee MY, Chou CY, Tang MJ and Shen MR:
Epithelial-mesenchymal transition in cervical cancer: Correlation
with tumor progression, epidermal growth factor receptor
overexpression, and snail up-regulation. Clin Cancer Res.
14:4743–4750. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Garg M: Epithelial, mesenchymal and hybrid
epithelial/mesenchymal phenotypes and their clinical relevance in
cancer metastasis. Expert Rev Mol Med. 19:e32017. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Piva F, Giulietti M, Santoni M, Occhipinti
G, Scarpelli M, Lopez-Beltran A, Cheng L, Principato G and
Montironi R: Epithelial to Mesenchymal Transition in Renal Cell
Carcinoma: Implications for Cancer Therapy. Mol Diagn Ther.
20:111–117. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Okubo K, Uenosono Y, Arigami T, Yanagita
S, Matsushita D, Kijima T, Amatatsu M, Uchikado Y, Kijima Y,
Maemura K, et al: Clinical significance of altering
epithelial-mesenchymal transition in metastatic lymph nodes of
gastric cancer. Gastric Cancer. 20:802–810. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
He H, Kuriyan AE, Su CW, Mahabole M, Zhang
Y, Zhu YT, Flynn HW, Parel JM and Tseng SC: Inhibition of
Proliferation and Epithelial Mesenchymal Transition in Retinal
Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3. Sci
Rep. 7:437362017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Yu M, Ting DT, Stott SL, Wittner BS,
Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, et
al: RNA sequencing of pancreatic circulating tumour cells
implicates WNT signalling in metastasis. Nature. 487:510–513. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Xu X, Su B, Xie C, Wei S, Zhou Y, Liu H,
Dai W, Cheng P, Wang F, Xu X, et al: Sonic hedgehog-Gli1 signaling
pathway regulates the epithelial mesenchymal transition (EMT) by
mediating a new target gene, S100A4, in pancreatic cancer cells.
PLoS One. 9:e964412014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad
A, Banerjee S, Azmi AS, Miele L and Sarkar FH: Notch-1 induces
epithelial-mesenchymal transition consistent with cancer stem cell
phenotype in pancreatic cancer cells. Cancer Lett. 307:26–36. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kaushik N, Kim MJ, Kim RK, Kumar Kaushik
N, Seong KM, Nam SY and Lee SJ: Low-dose radiation decreases tumor
progression via the inhibition of the JAK1/STAT3 signaling axis in
breast cancer cell lines. Sci Rep. 7:433612017. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Mobley RJ, Raghu D, Duke LD, Abell-Hart K,
Zawistowski JS, Lutz K, Gomez SM, Roy S, Homayouni R, Johnson GL,
et al: MAP3K4 Controls the Chromatin Modifier HDAC6 during
Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition. Cell
Reports. 18:2387–2400. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Qiu DZ, Zhang ZJ, Wu WZ and Yang YK:
Bufalin, a component in Chansu, inhibits proliferation and invasion
of hepatocellular carcinoma cells. BMC Complement Altern Med.
13:1852013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Li C, Hashimi SM, Cao S, Mellick AS, Duan
W, Good D and Wei MQ: The mechanisms of chansu in inducing
efficient apoptosis in colon cancer cells. Evid Based Complement
Alternat Med. 2013:8490542013.PubMed/NCBI
|
|
18
|
Zou Z, Luo X, Nie P, Wu B, Zhang T, Wei Y,
Wang W, Geng G, Jiang J and Mi Y: Inhibition of SRC-3 enhances
sensitivity of human cancer cells to histone deacetylase
inhibitors. Biochem Biophys Res Commun. 478:227–233. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhang J, Sha J, Zhou Y, Han K, Wang Y, Su
Y, Yin X, Hu H and Yao Y: Bufalin Inhibits Proliferation and
Induces Apoptosis in Osteosarcoma Cells by Downregulating
MicroRNA-221. Evid Based Complement Alternat Med. 2016:73194642016.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wang J, Chen C, Wang S, Zhang Y, Yin P,
Gao Z, Xu J, Feng D, Zuo Q, Zhao R, et al: Bufalin Inhibits HCT116
Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model
through Genes Related to Apoptotic and PTEN/AKT Pathways.
Gastroenterol Res Pract. 2015:4571932015. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Sun P, Feng LX, Zhang DM, Liu M, Liu W, Mi
T, Wu WY, Jiang BH, Yang M, Hu LH, et al: Bufalin derivative BF211
inhibits proteasome activity in human lung cancer cells in vitro by
inhibiting β1 subunit expression and disrupting proteasome
assembly. Acta Pharmacol Sin. 37:908–918. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wang H, Ning Z, Li Y, Zhu X and Meng Z:
Bufalin suppresses cancer stem-like cells in gemcitabine-resistant
pancreatic cancer cells via Hedgehog signaling. Mol Med Rep.
14:1907–1914. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Hong SH, Kim GY, Chang YC, Moon SK, Kim WJ
and Choi YH: Bufalin prevents the migration and invasion of T24
bladder carcinoma cells through the inactivation of matrix
metalloproteinases and modulation of tight junctions. Int J Oncol.
42:277–286. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang H, Zhang C, Xu L, Zang K, Ning Z,
Jiang F, Chi H, Zhu X and Meng Z: Bufalin suppresses hepatocellular
carcinoma invasion and metastasis by targeting HIF-1α via the
PI3K/AKT/mTOR pathway. Oncotarget. 7:20193–20208. 2016.PubMed/NCBI
|
|
25
|
Liu M, Feng LX, Sun P, Liu W, Wu WY, Jiang
BH, Yang M, Hu LH, Guo DA and Liu X: A Novel Bufalin Derivative
Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549
Lung Cancer Cells and Lower Acute Toxicity in Mice. PLoS One.
11:e01597892016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Shen S, Zhang Y, Wang Z, Liu R and Gong X:
Bufalin induces the interplay between apoptosis and autophagy in
glioma cells through endoplasmic reticulum stress. Int J Biol Sci.
10:212–224. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Liu X, Xiao XY, Shou QY, Yan JF, Chen L,
Fu HY and Wang JC: Bufalin inhibits pancreatic cancer by inducing
cell cycle arrest via the c-Myc/NF-κB pathway. J Ethnopharmacol.
193:538–545. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zhai X, Lu J, Wang Y, Fang F, Li B and Gu
W: Reversal effect of bufalin on multidrug resistance in K562/VCR
vincristine-resistant leukemia cell line. J Tradit Chin Med.
34:678–683. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Heldin CH, Vanlandewijck M and Moustakas
A: Regulation of EMT by TGFβ in cancer. FEBS Lett. 586:1959–1970.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Gaarenstroom T and Hill CS: TGF-β
signaling to chromatin: How Smads regulate transcription during
self-renewal and differentiation. Semin Cell Dev Biol. 32:107–118.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lombaerts M, van Wezel T, Philippo K,
Dierssen JW, Zimmerman RM, Oosting J, van Eijk R, Eilers PH, van de
Water B, Cornelisse CJ, et al: E-cadherin transcriptional
downregulation by promoter methylation but not mutation is related
to epithelial-to-mesenchymal transition in breast cancer cell
lines. Br J Cancer. 94:661–671. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kahata K, Dadras MS and Moustakas A: TGF-β
Family Signaling in Epithelial Differentiation and
Epithelial-Mesenchymal Transition. Cold Spring Harb Perspect Biol.
10:0221942018. View Article : Google Scholar
|
|
33
|
Ikushima H and Miyazono K: Cellular
context-dependent ‘colors’ of transforming growth factor-beta
signaling. Cancer Sci. 101:306–312. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhao L, Liu S, Che X, Hou K, Ma Y, Li C,
Wen T, Fan Y, Hu X, Liu Y, et al: Bufalin inhibits TGF-β-induced
epithelial-to-mesenchymal transition and migration in human lung
cancer A549 cells by downregulating TGF-β receptors. Int J Mol Med.
36:645–652. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhao R, Yu H, Shi X, Qiu Y, Qian Y and Yin
P: The influence of Bufalin on TGF-β1-induced epithelial
mesenchymal transition in HCT-116 cells. Surg Res N Tech.
4:217–222. 2015.
|
|
36
|
Wang S, Lin J, Xing L and Chen T:
Mechanism of Bufalin inhibiting invasion of human colon cancer
HCT116 cells. China J Cancer Prev Treat. 23:52016.
|
|
37
|
Wang SQ, Wang C, Chang LM, Zhou KR, Wang
JW, Ke Y, Yang DX, Shi HG, Wang R, Shi XL, et al: Geridonin and
paclitaxel act synergistically to inhibit the proliferation of
gastric cancer cells through ROS-mediated regulation of the
PTEN/PI3K/Akt pathway. Oncotarget. 7:72990–73002. 2016.PubMed/NCBI
|
|
38
|
Wang R, Song Y, Liu X, Wang Q, Wang Y, Li
L, Kang C and Zhang Q: UBE2C induces EMT through Wnt/β catenin and
PI3K/Akt signaling pathways by regulating phosphorylation levels of
Aurora-A. Int J Oncol. 50:1116–1126. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Yoo YA, Kang MH, Lee HJ, Kim BH, Park JK,
Kim HK, Kim JS and Oh SC: Sonic hedgehog pathway promotes
metastasis and lymphangiogenesis via activation of Akt, EMT, and
MMP-9 pathway in gastric cancer. Cancer Res. 71:7061–7070. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Hong KO, Kim JH, Hong JS, Yoon HJ, Lee JI,
Hong SP and Hong SD: Inhibition of Akt activity induces the
mesenchymal-to-epithelial reverting transition with restoring
E-cadherin expression in KB and KOSCC-25B oral squamous cell
carcinoma cells. J Exp Clin Cancer Res. 28:282009. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zhang L, Huang G, Li X, Zhang Y, Jiang Y,
Shen J, Liu J, Wang Q, Zhu J, Feng X, et al: Hypoxia induces
epithelial-mesenchymal transition via activation of SNAI1 by
hypoxia-inducible factor-1α in hepatocellular carcinoma. BMC
Cancer. 13:1–9. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chen YY, Lu HF, Hsu SC, Kuo CL, Chang SJ,
Lin JJ, Wu PP, Liu JY, Lee CH, Chung JG, et al: Bufalin inhibits
migration and invasion in human hepatocellular carcinoma SK-Hep1
cells through the inhibitions of NF-kB and matrix
metalloproteinase-2/-9-signaling pathways. Environ Toxicol.
30:74–82. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Liu F, Tong D, Li H, Liu M, Li J, Wang Z
and Cheng X: Bufalin enhances antitumor effect of paclitaxel on
cervical tumorigenesis via inhibiting the integrin α2/β5/FAK
signaling pathway. Oncotarget. 7:8896–8907. 2016.PubMed/NCBI
|
|
44
|
Nusse R and Varmus HE: Wnt genes. Cell.
69:1073–1087. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Serman L, Martic Nikuseva T, Serman A and
Vranic S: Epigenetic alterations of the Wnt signaling pathway in
cancer: A mini review. Bosn J Basic Med Sci. 14:191–194. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ma Y, Zhu B, Liu X, Yu H, Yong L, Liu X,
Shao J and Liu Z: Inhibition of oleandrin on the proliferation show
and invasion of osteosarcoma cells in vitro by suppressing
Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res. 34:1152015.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Kim K, Lu Z and Hay ED: Direct evidence
for a role of β-catenin/LEF-1 signaling pathway in induction of
EMT. Cell Biol Int. 26:463–476. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Gai JQ, Sheng X, Qin JM, Sun K, Zhao W and
Ni L: The effect and mechanism of bufalin on regulating
hepatocellular carcinoma cell invasion and metastasis via
Wnt/β-catenin signaling pathway. Int J Oncol. 48:338–348. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Nüsslein-Volhard C and Wieschaus E:
Mutations affecting segment number and polarity in Drosophila.
Nature. 287:795–801. 1980. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
McMillan R and Matsui W: Molecular
pathways: The hedgehog signaling pathway in cancer. Clin Cancer
Res. 18:4883–4888. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Chun HW and Hong R: Significance of the
hedgehog pathway-associated proteins Gli-1 and Gli-2 and the
epithelial-mesenchymal transition-associated proteins Twist and
E-cadherin in hepatocellular carcinoma. Oncol Lett. 12:1753–1762.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Hui CC and Angers S: Gli proteins in
development and disease. Annu Rev Cell Dev Biol. 27:513–537. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Chong Y, Tang D, Gao J, Jiang X, Xu C,
Xiong Q, Huang Y, Wang J, Zhou H, Shi Y, et al: Galectin-1 induces
invasion and the epithelial-mesenchymal transition in human gastric
cancer cells via non-canonical activation of the hedgehog signaling
pathway. Oncotarget. 7:83611–83626. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Sheng X, Sun X, Sun K, Sui H, Qin J and Li
Q: Inhibitory effect of bufalin combined with Hedgehog signaling
pathway inhibitors on proliferation and invasion and metastasis of
liver cancer cells. Int J Oncol. 49:1513–1524. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Sen R and Baltimore D: Multiple nuclear
factors interact with the immunoglobulin enhancer sequences. Cell
1986. 46: 705–716. J Immunol. 177:7485–7496. 2006.PubMed/NCBI
|
|
56
|
Karin M: NF-kappaB and cancer: Mechanisms
and targets. Mol Carcinog. 45:355–361. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Torii S, Yamamoto T, Tsuchiya Y and
Nishida E: ERK MAP kinase in G cell cycle progression and cancer.
Cancer Sci. 97:697–702. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Kim EK and Choi EJ: Pathological roles of
MAPK signaling pathways in human diseases. Biochim Biophys Acta.
1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Huang C, Jacobson K and Schaller MD: MAP
kinases and cell migration. J Cell Sci. 117:4619–4628. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y,
Zhang ZL, Ao J, Li B and Liu H: p38α MAPK regulates proliferation
and differentiation of osteoclast progenitors and bone remodeling
in an aging-dependent manner. Sci Rep. 7:459642017. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Chueh FS, Chen YY, Huang AC, Ho HC, Liao
CL, Yang JS, Kuo CL and Chung JG: Bufalin-inhibited migration and
invasion in human osteosarcoma U-2 OS cells is carried out by
suppression of the matrix metalloproteinase-2, ERK, and JNK
signaling pathways. Environ Toxicol. 29:21–29. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Krol J, Loedige I and Filipowicz W: The
widespread regulation of microRNA biogenesis, function and decay.
Nat Rev Genet. 11:597–610. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Othman N, In LL, Harikrishna JA and Hasima
N: Bcl-xL silencing induces alterations in hsa-miR-608 expression
and subsequent cell death in A549 and SK-LU1 human lung
adenocarcinoma cells. PLoS One. 8:e817352013. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Ho CS, Yap SH, Phuah NH, In LL and Hasima
N: MicroRNAs associated with tumour migration, invasion and
angiogenic properties in A549 and SK-Lu1 human lung adenocarcinoma
cells. Lung Cancer. 83:154–162. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Li Y, Su J, Li F, Chen X and Zhang G:
MiR-150 regulates human keratinocyte proliferation in hypoxic
conditions through targeting HIF-1α and VEGFA: Implications for
psoriasis treatment. PLoS One. 12:e01754592017. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Mohammadi A, Mansoori B and Baradaran B:
Regulation of miRNAs by herbal medicine: An emerging field in
cancer therapies. Biomed Pharmacother. 86:262–270. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Qiu YY, Hu Q, Tang QF, Feng W, Hu SJ,
Liang B, Peng W and Yin PH: MicroRNA-497 and bufalin act
synergistically to inhibit colorectal cancer metastasis. Tumour
Biol. 35:2599–2606. 2014. View Article : Google Scholar : PubMed/NCBI
|
