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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery

  • Authors:
    • Takashi Makino
    • Hajime Otsuka
    • Yoshinobu Hata
    • Satoshi Koezuka
    • Yoko Azuma
    • Kazutoshi Isobe
    • Keishi Sugino
    • Satoru Ebihara
    • Sakae Homma
    • Akira Iyoda
  • View Affiliations / Copyright

    Affiliations: Division of Chest Surgery, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan, Division of Respiratory Medicine, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan, Department of Rehabilitation Medicine, Toho University School of Medicine, Ota, Tokyo 143‑8541, Japan
  • Pages: 647-652
    |
    Published online on: March 26, 2018
       https://doi.org/10.3892/mco.2018.1595
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Abstract

Bronchodilators are essential for the perioperative management of patients with chronic obstructive pulmonary disease (COPD) undergoing surgery for lung cancer. The objective of the present study was to examine whether the usage of a long‑acting β2‑agonist (LABA) with a long‑acting muscarinic antagonist (LAMA) could optimize preoperative lung function and reduce the risk for postoperative pulmonary complications. Thirty‑two consecutive patients with moderate‑to‑severe COPD who underwent a lobectomy for lung cancer and received preoperative LAMA (n=19) or LAMA/LABA (n=13) therapy between January 2005 and December 2015 were enrolled in this retrospective study. The improvement of preoperative pulmonary function and the postoperative morbidity were compared between the patients with preoperative LAMA, and LAMA/LABA therapy. Increases in the forced expiratory volume in one second (FEV1) were significantly larger in the LAMA/LABA group than in the LAMA group (0.26±0.05 l vs. 0.07±0.05 l; P=0.0145). More patients in the LAMA/LABA group than in the LAMA group showed a marked improvement of >10% in %FEV1 after bronchodilators (85 vs. 32%; P=0.0046). The incidence of postoperative pneumonia was significantly lower in the LAMA/LABA group than in the LAMA group (0 vs. 26%; P=0.044). In conclusion, the present study showed that preoperative LAMA/LABA therapy was associated with larger improvements in preoperative pulmonary function and less postoperative pneumonia than LAMA therapy. These results may lead to greater improvements in FEV1 and less postoperative pneumonia by encouraging preoperative LAMA/LABA therapy in this patient population.
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1 

Mannino DM and Buist AS: Global burden of copd: Risk factors, prevalence, and future trends. Lancet. 370:765–773. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Anthonisen NR, Connett JE, Enright PL and Manfreda J: Lung Health Study Research G. Hospitalizations and mortality in the lung health study. Am J Respir Crit Care Med. 166:333–339. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, et al: Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: Gold executive summary. Am J Respir Crit Care Med. 176:532–555. 2007. View Article : Google Scholar : PubMed/NCBI

4 

de Torres JP, Marín JM, Casanova C, Cote C, Carrizo S, Cordoba-Lanus E, Baz-Dávila R, Zulueta JJ, Aguirre-Jaime A, Saetta M, et al: Lung cancer in patients with chronic obstructive pulmonary disease- incidence and predicting factors. Am J Respir Crit Care Med. 184:913–919. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Win T, Jackson A, Sharples L, Groves AM, Wells FC, Ritchie AJ and Laroche CM: Relationship between pulmonary function and lung cancer surgical outcome. Eur Respir J. 25:594–599. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Sekine Y, Kesler KA, Behnia M, Brooks-Brunn J, Sekine E and Brown JW: COPD may increase the incidence of refractory supraventricular arrhythmias following pulmonary resection for non-small cell lung cancer. Chest. 120:1783–1790. 2001. View Article : Google Scholar : PubMed/NCBI

7 

GOLD: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016 Global strategy for diagnosis, management and prevention of COPD. http://www.goldcopd.org/

8 

Vogelmeier C, Kardos P, Harari S, Gans SJ, Stenglein S and Thirlwell J: Formoterol mono- and combination therapy with tiotropium in patients with copd: A 6-month study. Respir Med. 102:1511–1520. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Tashkin DP, Pearle J, Iezzoni D and Varghese ST: Formoterol and tiotropium compared with tiotropium alone for treatment of COPD. COPD. 6:17–25. 2009. View Article : Google Scholar : PubMed/NCBI

10 

van Noord JA, Aumann JL, Janssens E, Smeets JJ, Verhaert J, Disse B, Mueller A and Cornelissen PJ: Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD. Eur Respir J. 26:214–222. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Bateman ED, Ferguson GT, Barnes N, Gallagher N, Green Y, Henley M and Banerji D: Dual bronchodilation with QVA149 versus single bronchodilator therapy: The SHINE study. Eur Respir J. 42:1484–1494. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Donohue JF, Maleki-Yazdi MR, Kilbride S, Mehta R, Kalberg C and Church A: Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 mcg in COPD. Respir Med. 107:1538–1546. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Kobayashi S, Suzuki S, Niikawa H, Sugawara T and Yanai M: Preoperative use of inhaled tiotropium in lung cancer patients with untreated COPD. Respirology. 14:675–679. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Nojiri T, Inoue M, Yamamoto K, Maeda H, Takeuchi Y, Nakagiri T, Shintani Y, Minami M, Sawabata N, Okumura M, et al: Inhaled tiotropium to prevent postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery. Surg Today. 44:285–290. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Bolukbas S, Eberlein M, Eckhoff J and Schirren J: Short-term effects of inhalative tiotropium/formoterol/budenoside versus tiotropium/formoterol in patients with newly diagnosed chronic obstructive pulmonary disease requiring surgery for lung cancer: A prospective randomized trial. Eur J Cardiothorac Surg. 39:995–1000. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Lopez-Encuentra A, Astudillo J, Cerezal J, Gonzalez-Aragoneses F, Novoa N and Sánchez-Palencia A: Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S): Prognostic value of chronic obstructive pulmonary disease in 2994 cases of lung cancer. Eur J Cardiothorac Surg. 27:8–13. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Leo F, Venissac N, Pop D, Solli P, Filosso P, Minniti A, Radice D, Mouroux J, Spaggiari L, Pastorino U, et al: Postoperative exacerbation of chronic obstructive pulmonary disease. Does it exist? Eur J Cardiothorac Surg. 33:424–429. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Nojiri T, Yamamoto K, Maeda H, Takeuchi Y, Funakoshi Y, Maekura R and Okumura M: Effects of inhaled tiotropium on left ventricular diastolic function in chronic obstructive pulmonary disease patients after pulmonary resection. Ann Thorac Cardiovasc Surg. 18:206–211. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Ueda K, Tanaka T, Hayashi M and Hamano K: Role of inhaled tiotropium on the perioperative outcomes of patients with lung cancer and chronic obstructive pulmonary disease. Thorac Cardiovasc Surg. 58:38–42. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Halpin D: Nice guidance for COPD. Thorax. 59:181–182. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Makino T, Otsuka H, Hata Y, Koezuka S, Azuma Y, Isobe K, Sugino K, Ebihara S, Homma S, Iyoda A, Iyoda A, et al: Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery. Mol Clin Oncol 8: 647-652, 2018.
APA
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K. ... Iyoda, A. (2018). Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery. Molecular and Clinical Oncology, 8, 647-652. https://doi.org/10.3892/mco.2018.1595
MLA
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K., Sugino, K., Ebihara, S., Homma, S., Iyoda, A."Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery". Molecular and Clinical Oncology 8.5 (2018): 647-652.
Chicago
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K., Sugino, K., Ebihara, S., Homma, S., Iyoda, A."Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery". Molecular and Clinical Oncology 8, no. 5 (2018): 647-652. https://doi.org/10.3892/mco.2018.1595
Copy and paste a formatted citation
x
Spandidos Publications style
Makino T, Otsuka H, Hata Y, Koezuka S, Azuma Y, Isobe K, Sugino K, Ebihara S, Homma S, Iyoda A, Iyoda A, et al: Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery. Mol Clin Oncol 8: 647-652, 2018.
APA
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K. ... Iyoda, A. (2018). Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery. Molecular and Clinical Oncology, 8, 647-652. https://doi.org/10.3892/mco.2018.1595
MLA
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K., Sugino, K., Ebihara, S., Homma, S., Iyoda, A."Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery". Molecular and Clinical Oncology 8.5 (2018): 647-652.
Chicago
Makino, T., Otsuka, H., Hata, Y., Koezuka, S., Azuma, Y., Isobe, K., Sugino, K., Ebihara, S., Homma, S., Iyoda, A."Long‑acting muscarinic antagonist and long‑acting β2‑agonist therapy to optimize chronic obstructive pulmonary disease prior to lung cancer surgery". Molecular and Clinical Oncology 8, no. 5 (2018): 647-652. https://doi.org/10.3892/mco.2018.1595
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