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Article

Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation

  • Authors:
    • Jinling Zhang
    • Yuanyuan Liu
    • Fengyuan Che
    • Yi Luo
    • Wei Huang
    • Xueyuan Heng
    • Baosheng Li
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Linyi People's Hospital Affiliated to Shandong University, Linyi, Shandong 276000, P.R. China, Cancer Center and Steering Committee, Linyi People's Hospital Affiliated to Shandong University, Linyi, Shandong 276000, P.R. China, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48105, USA, Department of Radiation Oncology (Chest Section), Shandong Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, Shandong 250117, P.R. China
  • Pages: 760-766
    |
    Published online on: April 13, 2018
       https://doi.org/10.3892/mco.2018.1606
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Abstract

The aim of the present study was to explore the pattern of lymph node metastasis (LNM) in poorly‑differentiated esophageal squamous cell carcinoma (pdESCC) and the implication of postoperative irradiation. A total of 690 patients with pdESCC were retrospectively investigated. The rates of intro‑thoracic and extra‑thoracic LNM in pdESCC were investigated and compared to previous research on ESCC en bloc. The comparison of the rates between pdESCC and ESCC were performed using the Cochran‑Mantel‑Haenszel test. The clinicopathological factors associated with LNM in pdESCC were analyzed by Chi‑squared tests, and Fisher's exact test was used to assess the rate difference of extra‑thoracic LNM. Logistic‑regression analysis was used to explore risk factors associated with lymph node (LN) station. Results demonstrated that the distribution pattern of LNM in pdESCC was significantly different compared with that of ESCC (P<0.05). Univariate and multivariate analysis indicated that risk factors associated with LNM were depth and length (P<0.001 and P<0.001) and multivariate analysis also indicated that the location of the tumor (P=0.042) was a risk factor associated with LNM in pdESCC. Metastasis in the abdominal cavity was significantly higher than in the neck in the middle and lower thoracic pdESCC (both P<0.01). LN station 102 and 7 for upper thoracic ESCC, 101 and 105 for middle thoracic ESCC, and 100 for lower thoracic ESCC were identified as high‑risk stations for metastases in pdESCC compared to ESCC. Several parameters, including location and neck metastasis, were identified as risk factors of metastasis for the above sites, respectively. In conclusion, postoperative therapy should include more LN stations in pdESCC depending on risk factors of tumor metastasis individually.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Liu Y, Che F, Luo Y, Huang W, Heng X and Li B: Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation. Mol Clin Oncol 8: 760-766, 2018.
APA
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., & Li, B. (2018). Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation. Molecular and Clinical Oncology, 8, 760-766. https://doi.org/10.3892/mco.2018.1606
MLA
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., Li, B."Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation". Molecular and Clinical Oncology 8.6 (2018): 760-766.
Chicago
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., Li, B."Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation". Molecular and Clinical Oncology 8, no. 6 (2018): 760-766. https://doi.org/10.3892/mco.2018.1606
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Liu Y, Che F, Luo Y, Huang W, Heng X and Li B: Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation. Mol Clin Oncol 8: 760-766, 2018.
APA
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., & Li, B. (2018). Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation. Molecular and Clinical Oncology, 8, 760-766. https://doi.org/10.3892/mco.2018.1606
MLA
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., Li, B."Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation". Molecular and Clinical Oncology 8.6 (2018): 760-766.
Chicago
Zhang, J., Liu, Y., Che, F., Luo, Y., Huang, W., Heng, X., Li, B."Pattern of lymph node metastasis in thoracic esophageal squamous cell carcinoma with poor differentiation". Molecular and Clinical Oncology 8, no. 6 (2018): 760-766. https://doi.org/10.3892/mco.2018.1606
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