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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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June-2018 Volume 8 Issue 6

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Case Report

Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report

  • Authors:
    • Shun Yin Kong
    • Wing Kit Lam
    • Ka Shu Li
    • Ka Pik Yeung
    • Chung Yin Ha
    • Ho Kei Lai
    • Hay Nun Chan
    • Yiu Ming Yeung
    • Sze Fai Yip

  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, SAR 999077, P.R. China, Department of Pathology, Tuen Mun Hospital, Hong Kong, SAR 999077, P.R. China
  • Pages: 757-759
    |
    Published online on: April 24, 2018
       https://doi.org/10.3892/mco.2018.1612
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Abstract

t(11;14) translocation is one of the most common chromosomal abnormalities in plasma cell myeloma. The present case report presented a case of plasma cell myeloma with t(11;14) translocation, in which the plasma cells were small lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and Cyclin D1 expression. These results led to initial diagnostic difficulties. The patient was refractory to bortezomib-based therapy, and responsive to vincristine, doxorubicin and dexamethasone. However, the prognostic value of t(11;14) in plasma cell myeloma remains to be determined. With recent advances in treatment options, physicians should be aware of the clinical and pathological characteristics of this translocation in plasma cell myeloma.
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Copy and paste a formatted citation
Spandidos Publications style
Kong S, Lam W, Li K, Yeung K, Ha C, Lai H, Chan H, Yeung Y and Yip S: Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report. Mol Clin Oncol 8: 757-759, 2018.
APA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H. ... Yip, S. (2018). Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report. Molecular and Clinical Oncology, 8, 757-759. https://doi.org/10.3892/mco.2018.1612
MLA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8.6 (2018): 757-759.
Chicago
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8, no. 6 (2018): 757-759. https://doi.org/10.3892/mco.2018.1612
Copy and paste a formatted citation
x
Spandidos Publications style
Kong S, Lam W, Li K, Yeung K, Ha C, Lai H, Chan H, Yeung Y and Yip S: Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report. Mol Clin Oncol 8: 757-759, 2018.
APA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H. ... Yip, S. (2018). Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report. Molecular and Clinical Oncology, 8, 757-759. https://doi.org/10.3892/mco.2018.1612
MLA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8.6 (2018): 757-759.
Chicago
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8, no. 6 (2018): 757-759. https://doi.org/10.3892/mco.2018.1612
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