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The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer

  • Authors:
    • Katsuhiro Okuda
    • Tsutomu Tatematsu
    • Motoki Yano
    • Katsumi Nakamae
    • Takeshi Yamada
    • Toshio Kasugai
    • Tsutomu Nishida
    • Masaaki Sano
    • Satoru Moriyama
    • Hiroshi Haneda
    • Osamu Kawano
    • Tadashi Sakane
    • Risa Oda
    • Takuya Watanabe
    • Ryoichi Nakanishi
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467‑8601, Japan, Department of Surgery, Aichi Medical University, Nagakute, Aichi 480‑1195, Japan, Department of Surgery, Nagoya City West Medical Center, Nagoya, Aichi 462‑8508, Japan, Department of Surgery, Kariya Toyota General Hospital, Kariya, Aichi 448‑8505, Japan, Department of Surgery, Matsunami General Hospital, Hashima, Gifu 501‑6062, Japan, Department of Surgery, Toyokawa City Hospital, Toyokawa, Aichi 442‑8561, Japan, Department of Surgery, Nagoya Memorial Hospital, Nagoya, Aichi 468‑8520, Japan
    Copyright: © Okuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 21-29
    |
    Published online on: May 4, 2018
       https://doi.org/10.3892/mco.2018.1619
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Abstract

Previous studies have reported that the expressions of specific proteins may predict the efficacy of chemotherapy agents for non‑small cell lung cancer (NSCLC) patients. The present study evaluated the expression of proteins hypothesized to be associated with the effect of chemotherapeutic agents in 38 NSCLC patients with pathological stage II and IIIA. The subjects received carboplatin plus paclitaxel (CP) or S‑1 as adjuvant chemotherapy following complete resection. The protein expressions evaluated were those of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phsphoribosyltransferase (OPRT), which were suspected to be associated with the effect of S‑1 agents, excision repair cross‑complementation group 1 (ERCC1), which was suspected to be associated with the effect of platinum‑based agents, and class III β‑tubulin (TUBB3), which was suspected to be associated with the effect of taxane‑based agents. The positive rate of TS was 55.3% (n=21/38), DPD was 57.9% (n=22/38), OPRT was 42.1% (n=16/38), ERCC1 was 47.4% (n=18/38) and TUBB3 was 44.7% (n=17/38). Among the patients who received S‑1 adjuvant chemotherapy, TS‑negative cases demonstrated a significantly better disease‑free survival than positive cases. Thus, TS protein expression may have been a factor that predicted the effect of S‑1 agent as adjuvant chemotherapy.
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Okuda K, Tatematsu T, Yano M, Nakamae K, Yamada T, Kasugai T, Nishida T, Sano M, Moriyama S, Haneda H, Haneda H, et al: The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer. Mol Clin Oncol 9: 21-29, 2018.
APA
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T. ... Nakanishi, R. (2018). The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer. Molecular and Clinical Oncology, 9, 21-29. https://doi.org/10.3892/mco.2018.1619
MLA
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T., Nishida, T., Sano, M., Moriyama, S., Haneda, H., Kawano, O., Sakane, T., Oda, R., Watanabe, T., Nakanishi, R."The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 21-29.
Chicago
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T., Nishida, T., Sano, M., Moriyama, S., Haneda, H., Kawano, O., Sakane, T., Oda, R., Watanabe, T., Nakanishi, R."The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 21-29. https://doi.org/10.3892/mco.2018.1619
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Spandidos Publications style
Okuda K, Tatematsu T, Yano M, Nakamae K, Yamada T, Kasugai T, Nishida T, Sano M, Moriyama S, Haneda H, Haneda H, et al: The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer. Mol Clin Oncol 9: 21-29, 2018.
APA
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T. ... Nakanishi, R. (2018). The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer. Molecular and Clinical Oncology, 9, 21-29. https://doi.org/10.3892/mco.2018.1619
MLA
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T., Nishida, T., Sano, M., Moriyama, S., Haneda, H., Kawano, O., Sakane, T., Oda, R., Watanabe, T., Nakanishi, R."The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 21-29.
Chicago
Okuda, K., Tatematsu, T., Yano, M., Nakamae, K., Yamada, T., Kasugai, T., Nishida, T., Sano, M., Moriyama, S., Haneda, H., Kawano, O., Sakane, T., Oda, R., Watanabe, T., Nakanishi, R."The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross‑complementation group 1 and class III β‑tubulin, and the therapeutic effect of S‑1 or carboplatin plus paclitaxel in non‑small‑cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 21-29. https://doi.org/10.3892/mco.2018.1619
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