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Article

Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer

  • Authors:
    • Yue‑Hua Zhang
    • Yuquan Lu
    • Hong Lu
    • Meng‑Wei Zhang
    • Yue‑Min Zhou
    • Xiang‑Lei Li
    • Pin Lv
    • Xiao‑Yan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Huaihe Hospital of Henan University, Kaifeng, Henan 475001, P.R. China, International Joint Research Laboratory for Cell Medical Engineering of Henan, Huaihe Hospital of Henan University, Kaifeng, Henan 475001, P.R. China
  • Pages: 44-49
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/mco.2018.1628
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Abstract

To date, few studies have reported the prognostic value of pre‑treatment hemoglobin levels in patients with non‑small cell lung cancer (NSCLC). In the present study, 416 patients with NSCLC were retrospectively reviewed. Univariate Cox proportional hazards regression analysis demonstrated that patients with normal pre‑treatment hemoglobin (NPHb) levels had a greater chance of surviving for longer period, than did patients with low pre‑treatment hemoglobin (LPHb) levels (HR, 2.05; 95% CI, 1.63‑2.57; P<0.001). After adjustment for age, sex, tumor‑node‑metastasis stage, Karnofsky performance status, lung lobectomy, chemotherapy and radiotherapy, multivariate Cox proportional hazards regression analysis revealed that LPHb was an independent predictor for the poor prognosis of patients with NSCLC (HR, 1.86; 95% CI, 1.47‑2.36; P<0.001). Estimation of the cumulative survival revealed that the overall survival of NPHb patients was significantly higher than that for LBHb patients (P<0.05), independent of whether the patients had received lung lobectomy or chemotherapy treatments. In conclusion, low pre‑treatment hemoglobin levels were demonstrated to be an independent biomarker for poor prognosis in patients with NSCLC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Alberg AJ, Brock MV, Ford JG, Samet JM and Spivack SD: Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 143 5 Suppl:e1S–e29S. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, et al: Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:504–535. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Clark GM: Prognostic factors versus predictive factors: Examples from a clinical trial of erlotinib. Mol Oncol. 1:406–412. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Brown T, Pilkington G, Bagust A, Boland A, Oyee J, Tudur-Smith C, Blundell M, Lai M, Saborido Martin C, Greenhalgh J, et al: Clinical effectiveness and cost-effectiveness of first-line chemotherapy for adult patients with locally advanced or metastatic non-small cell lung cancer: A systematic review and economic evaluation. Health Technol Assess. 17:1–278. 2013. View Article : Google Scholar

6 

Greenhalgh J, Dwan K, Boland A, Bates V, Vecchio F, Dundar Y, Jain P and Green JA: First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer. Cochrane Database Syst Rev: CD010383. 2016. View Article : Google Scholar

7 

Palma JF, Das P and Liesenfeld O: Lung cancer screening: Utility of molecular applications in conjunction with low-dose computed tomography guidelines. Expert Rev Mol Diagn. 16:435–447. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Tomita M, Shimizu T, Hara M, Ayabe T and Onitsuka T: Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients. Anticancer Res. 28:1947–1950. 2008.PubMed/NCBI

9 

Gauthier I, Ding K, Winton T, Shepherd FA, Livingston R, Johnson DH, Rigas JR, Whitehead M, Graham B and Seymour L: Impact of hemoglobin levels on outcomes of adjuvant chemotherapy in resected non-small cell lung cancer: The JBR.10 trial experience. Lung Cancer. 55:357–363. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Aoe K, Hiraki A, Maeda T, Katayama H, Fujiwara K, Tabata M, Kiura K, Ueoka H and Tanimoto M: Serum hemoglobin level determined at the first presentation is a poor prognostic indicator in patients with lung cancer. Intern Med. 44:800–804. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Trufelli DC, Moraes TV, Lima AA and Giglio AD: Epidemiological profile and prognostic factors in patients with lung cancer. Rev Assoc Med Bras (1992). 62:428–433. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Watine J: Blood hemoglobin as an independent prognostic factor in surgically resected stages I and II non-small cell lung cancer patients. Ann Thorac Surg. 73:2034–2035, Author reply 2035. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Kay FU, Kandathil A, Batra K, Saboo SS, Abbara S and Rajiah P: Revisions to the tumor, node, metastasis staging of lung cancer (8th edition): Rationale, radiologic findings and clinical implications. World J Radiol. 9:269–279. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Schag CC, Heinrich RL and Ganz PA: Karnofsky performance status revisited: Reliability, validity, and guidelines. J Clin Oncol. 2:187–193. 1984. View Article : Google Scholar : PubMed/NCBI

15 

Langendijk H, de Jong J, Wanders R, Lambin P and Slotman B: The importance of pre-treatment haemoglobin level in inoperable non-small cell lung carcinoma treated with radical radiotherapy. Radiother Oncol. 67:321–325. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Holgersson G, Sandelin M, Hoye E, Bergström S, Henriksson R, Ekman S, Nyman J, Helsing M, Friesland S, Holgersson M, et al: Swedish lung cancer radiation study group: The prognostic value of anaemia, thrombocytosis and leukocytosis at time of diagnosis in patients with non-small cell lung cancer. Med Oncol. 29:3176–3182. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ray-Coquard I, Morère JF, Scotté F, Cals L and Antoine EC: Management of anemia in advanced breast and lung cancer patients in daily practice: Results of a French survey. Adv Ther. 29:124–133. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Vannella L, Lahner E, Osborn J and Annibale B: Systematic review: Gastric cancer incidence in pernicious anaemia. Aliment Pharmacol Ther. 37:375–382. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Altman AD, Liu XQ, Nelson G, Chu P, Nation J and Ghatage P: The effects of anemia and blood transfusion on patients with stage III–IV ovarian cancer. Int J Gynecol Cancer. 23:1569–1576. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Banzet S, Sanchez H, Chapot R, Bigard X, Vaulont S and Koulmann N: Interleukin-6 contributes to hepcidin mRNA increase in response to exercise. Cytokine. 58:158–161. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Sun CC, Vaja V, Babitt JL and Lin HY: Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol. 87:392–400. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wu Y, Antony S, Meitzler JL and Doroshow JH: Molecular mechanisms underlying chronic inflammation-associated cancers. Cancer Lett. 345:164–173. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Aapro M, Jelkmann W, Constantinescu SN and Leyland-Jones B: Effects of erythropoietin receptors and erythropoiesis-stimulating agents on disease progression in cancer. Br J Cancer. 106:1249–1258. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Tefferi A, Hudgens S, Mesa R, Gale RP, Verstovsek S, Passamonti F, Cervantes F, Rivera C, Tencer T and Khan ZM: Use of the functional assessment of cancer therapy-anemia in persons with myeloproliferative neoplasm-associated myelofibrosis and anemia. Clin Ther. 36:560–566. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC and Seagroves TN: Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res. 14:R62012. View Article : Google Scholar : PubMed/NCBI

26 

Li S, Meng W, Guan Z, Guo Y and Han X: The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment. Biomed Pharmacother. 80:127–135. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Milane L, Duan Z and Amiji M: Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning. Cancer Cell Int. 11:32011. View Article : Google Scholar : PubMed/NCBI

28 

Ost D, Goldberg J, Rolnitzky L and Rom WN: Survival after surgery in stage IA and IB non-small cell lung cancer. Am J Respir Crit Care Med. 177:516–523. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Tanaka F, Yanagihara K, Otake Y, Miyahara R, Kawano Y, Nakagawa T, Shoji T and Wada H: Surgery for non-small cell lung cancer: Postoperative survival based on the revised tumor-node-metastasis classification and its time trend. Eur J Cardiothorac Surg. 18:147–155. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang YH, Lu Y, Lu H, Zhang MW, Zhou YM, Li XL, Lv P and Zhao XY: Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer. Mol Clin Oncol 9: 44-49, 2018.
APA
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X. ... Zhao, X. (2018). Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer. Molecular and Clinical Oncology, 9, 44-49. https://doi.org/10.3892/mco.2018.1628
MLA
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X., Lv, P., Zhao, X."Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 44-49.
Chicago
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X., Lv, P., Zhao, X."Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 44-49. https://doi.org/10.3892/mco.2018.1628
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang YH, Lu Y, Lu H, Zhang MW, Zhou YM, Li XL, Lv P and Zhao XY: Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer. Mol Clin Oncol 9: 44-49, 2018.
APA
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X. ... Zhao, X. (2018). Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer. Molecular and Clinical Oncology, 9, 44-49. https://doi.org/10.3892/mco.2018.1628
MLA
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X., Lv, P., Zhao, X."Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer". Molecular and Clinical Oncology 9.1 (2018): 44-49.
Chicago
Zhang, Y., Lu, Y., Lu, H., Zhang, M., Zhou, Y., Li, X., Lv, P., Zhao, X."Pre‑treatment hemoglobin levels are an independent prognostic factor in patients with non‑small cell lung cancer". Molecular and Clinical Oncology 9, no. 1 (2018): 44-49. https://doi.org/10.3892/mco.2018.1628
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