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Article

Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition

  • Authors:
    • Carlo Capalbo
    • Francesca Belardinilli
    • Marco Filetti
    • Claudia Parisi
    • Marialaura Petroni
    • Valeria Colicchia
    • Alessandra Tessitore
    • Matteo Santoni
    • Anna Coppa
    • Giuseppe Giannini
    • Paolo Marchetti
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine, Sapienza University of Rome, I‑00161 Rome, Italy, Medical Oncology Sant'Andrea Hospital, I‑00189 Rome, Italy, Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, I‑00161 Rome, Italy, Oncology Unit, Macerata Hospital, I‑62100 Macerata, Italy, Department of Experimental Medicine, Sapienza University of Rome, I‑00161 Rome, Italy
  • Pages: 30-34
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/mco.2018.1634
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Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non‑melanoma skin cancer. Platinum‑based regimens have been an integral part of palliative care for patients with locally advanced or metastatic disease. There is no evidence of efficacy for later lines of chemotherapy and no targeted therapy has been introduced as ‘standard of care’. Here we report on the case of an elderly cSCC patient, resistant to conventional therapy, however successfully treated with anti‑epidermal growth factor receptor (EGFR) agent (Cetuximab) in addition to a daily dose of Curcumin phospholipid. The patient responded to treatment and experienced no recurrence for 11 months with only minor skin‑related toxicity. To our knowledge, this is the first report of clinical evidence that an anti EGFR targeted therapy with a daily oral dose of Curcumin phospholipid is well tolerated and results in a highly effective disease control in a heavily pretreated cSCC patient.
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1 

Green AC and Olsen CM: Cutaneous squamous cell carcinoma: An epidemiological review. Br J Dermatol. 177:373–381. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Behan JW, Sutton A and Wysong A: Management of skin cancer in the high-risk patient. Curr Treat Options Oncol. 17:602016. View Article : Google Scholar : PubMed/NCBI

3 

Swick AD, Prabakaran PJ, Miller MC, Javaid AM, Fisher MM, Sampene E, Ong IM, Hu R, Iida M, Nickel KP, et al: Cotargeting mTORC and EGFR signaling as a therapeutic strategy in HNSCC. Mol Cancer Ther. 16:1257–1268. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Iglesias-Bartolome R, Martin D and Gutkind JS: Exploiting the head and neck cancer oncogenome: Widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov. 3:722–725. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Al-Rohil RN, Tarasen AJ, Carlson JA, Wang K, Johnson A, Yelensky R, Lipson D, Elvin JA, Vergilio JA, Ali SM, et al: Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies. Cancer. 122:249–257. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Suen JK, Bressler L, Shord SS, Warso M and Villano JL: Cutaneous squamous cell carcinoma responding serially to single-agent cetuximab. Anticancer Drugs. 18:827–829. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Yang X, Li Z, Wang N, Li L, Song L, He T, Sun L, Wang Z, Wu Q, Luo N, et al: Curcumin-encapsulated polymeric micelles suppress the development of colon cancer in vitro and in vivo. Sci Rep. 5:103222015. View Article : Google Scholar : PubMed/NCBI

8 

Starok M, Preira P, Vayssade M, Haupt K, Salomé L and Rossi C: EGFR inhibition by curcumin in cancer cells: A dual mode of action. Biomacromolecules. 16:1634–1642. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wada K, Lee JY, Hung HY, Shi Q, Lin L, Zhao Y, Goto M, Yang PC, Kuo SC, Chen HW and Lee KH: Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Bioorg Med Chem. 23:1507–1514. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Kasi PD, Tamilselvam R, Skalicka-Woźniak K, Nabavi SF, Daglia M, Bishayee A, Pazoki-Toroudi H and Nabavi SM: Molecular targets of curcumin for cancer therapy: An updated review. Tumour Biol. 37:13017–13028. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Wu J, Lu WY and Cui LL: Inhibitory effect of curcumin on invasion of skin squamous cell carcinoma A431 cells. Asian Pac J Cancer Prev. 16:2813–2818. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Phillips JM, Clark C, Herman-Ferdinandez L, Moore-Medlin T, Rong X, Gill JR, Clifford JL, Abreo F and Nathan CO: Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. Otolaryngol Head Neck Surg. 145:58–63. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Giannini G, Capalbo C, Ottini L, Buffone A, de Marchis L, Margaria E, Vitolo D, Ricevuto E, Rinaldi C, Zani M, et al: Clinical classification of BRCA1 DNA missense variants: H1686Q is a novel pathogenic mutation occurring in the ontogenetically invariant THV motif of the N-terminal BRCT domain. J Clin Oncol. 26:4212–4214; author reply, 4214–4215. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Maubec E, Petrow P, Scheer-Senyarich I, Duvillard P, Lacroix L, Gelly J, Certain A, Duval X, Crickx B, Buffard V, et al: Phase II study of cetuximab as first-line single-drug therapy in patients with unresectable squamous cell carcinoma of the skin. J Clin Oncol. 29:3419–3426. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Belardinilli F, Capalbo C, Buffone A, Petroni M, Colicchia V, Ferraro S, Zani M, Nicolussi A, D'Inzeo S, Coppa A, et al: Validation of the Ion Torrent PGM sequencing for the prospective routine molecular diagnostic of colorectal cancer. Clin Biochem. 48:908–910. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Capalbo C, Marchetti P, Coppa A, Calogero A, Anastasi E, Buffone A, Belardinilli F, Gulino M, Frati P, Catalano C, et al: Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer: A case report. Cancer Biol Ther. 15:826–831. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Toll A, Salgado R, Yébenes M, Martín-Ezquerra G, Gilaberte M, Baró T, Solé F, Alameda F, Espinet B and Pujol RM: Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas. Exp Dermatol. 19:151–153. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Schwaederle M, Elkin SK, Tomson BN, Carter JL and Kurzrock R: Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types. Cell Cycle. 14:2355–2361. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, et al: Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 20:6582–6592. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Shimizu T, Izumi H, Oga A, Furumoto H, Murakami T, Ofuji R, Muto M and Sasaki K: Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology. 202:203–206. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Wollina U: Cetuximab in non-melanoma skin cancer. Expert Opin Biol Ther. 12:949–956. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Seber S, Gonultas A, Ozturk O and Yetisyigit T: Recurrent squamous cell carcinoma of the skin treated successfully with single agent cetuximab therapy. Onco Targets Ther. 9:945–948. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Takagi M, Kouwaki M, Kawase K, Shinohara H, Hasegawa Y, Yamada T, Fujiwara I, Sawai H, Nishimura G and Hasegawa T: A novel mutation Ser344Cys in FGFR3 causes achondroplasia with severe platyspondyly. Am J Med Genet A. 167A:2851–2854. 2015. View Article : Google Scholar : PubMed/NCBI

24 

L'Hôte CG and Knowles MA: Cell responses to FGFR3 signalling: Growth, differentiation and apoptosis. Exp Cell Res. 304:417–431. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Shtraizent N, Matsui H, Polotskaia A and Bargonetti J: Hot spot mutation in TP53 (R248Q) causes oncogenic gain-of-function phenotypes in a breast cancer cell line derived from an African American patient. Int J Environ Res Public Health. 13:ijerph130100222015. View Article : Google Scholar : PubMed/NCBI

26 

Muller PA and Vousden KH: Mutant p53 in cancer: New functions and therapeutic opportunities. Cancer Cell. 25:304–317. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Xu J, Wang J, Hu Y, Qian J, Xu B, Chen H, Zou W and Fang JY: Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity. Cell Death Dis. 5:e11082014. View Article : Google Scholar : PubMed/NCBI

28 

Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA and Sartor RB: Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 163:3474–3483. 1999.PubMed/NCBI

29 

Li S, Liu Z, Zhu F, Fan X, Wu X, Zhao H and Jiang L: Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Oncol Res. 21:137–144. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Olivier M, Hollstein M and Hainaut P: TP53 mutations in human cancers: Origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2:a0010082010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Capalbo C, Belardinilli F, Filetti M, Parisi C, Petroni M, Colicchia V, Tessitore A, Santoni M, Coppa A, Giannini G, Giannini G, et al: Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition. Mol Clin Oncol 9: 30-34, 2018.
APA
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V. ... Marchetti, P. (2018). Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition. Molecular and Clinical Oncology, 9, 30-34. https://doi.org/10.3892/mco.2018.1634
MLA
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V., Tessitore, A., Santoni, M., Coppa, A., Giannini, G., Marchetti, P."Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition". Molecular and Clinical Oncology 9.1 (2018): 30-34.
Chicago
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V., Tessitore, A., Santoni, M., Coppa, A., Giannini, G., Marchetti, P."Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition". Molecular and Clinical Oncology 9, no. 1 (2018): 30-34. https://doi.org/10.3892/mco.2018.1634
Copy and paste a formatted citation
x
Spandidos Publications style
Capalbo C, Belardinilli F, Filetti M, Parisi C, Petroni M, Colicchia V, Tessitore A, Santoni M, Coppa A, Giannini G, Giannini G, et al: Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition. Mol Clin Oncol 9: 30-34, 2018.
APA
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V. ... Marchetti, P. (2018). Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition. Molecular and Clinical Oncology, 9, 30-34. https://doi.org/10.3892/mco.2018.1634
MLA
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V., Tessitore, A., Santoni, M., Coppa, A., Giannini, G., Marchetti, P."Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition". Molecular and Clinical Oncology 9.1 (2018): 30-34.
Chicago
Capalbo, C., Belardinilli, F., Filetti, M., Parisi, C., Petroni, M., Colicchia, V., Tessitore, A., Santoni, M., Coppa, A., Giannini, G., Marchetti, P."Effective treatment of a platinum‑resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition". Molecular and Clinical Oncology 9, no. 1 (2018): 30-34. https://doi.org/10.3892/mco.2018.1634
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