Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
August-2018 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report

  • Authors:
    • Yutaka Okagawa
    • Tetsuya Sumiyoshi
    • Hideyuki Ihara
    • Shutaro Oiwa
    • Kaho Tokuchi
    • Masahiro Yoshida
    • Ryoji Fujii
    • Takeyoshi Minagawa
    • Kohtaro Morita
    • Michiaki Hirayama
    • Hitoshi Kondo
    • Yumiko Oyamada
    • Yo Kawarada
    • Shuji Kitashiro
    • Shunichi Okushiba
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Tonan Hospital, Sapporo, Hokkaido 060-0004, Japan, Department of Pathology, Tonan Hospital, Sapporo, Hokkaido 060-0004, Japan, Department of Surgery, Tonan Hospital, Sapporo, Hokkaido 060-0004, Japan
    Copyright: © Okagawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 168-172
    |
    Published online on: May 25, 2018
       https://doi.org/10.3892/mco.2018.1639
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastrointestinal stromal tumors (GIST) typically appear as solid masses, and cystic formation is uncommon. Most stomach GISTs with cystic formation progress outside the gastric wall and are frequently misdiagnosed as epigastric cystic tumors derived from pancreas or liver. An asymptomatic 72-year-old male underwent esophagogastroduodenoscopy, which revealed a submucosal tumor (SMT), approximately 50 mm in diameter, at the anterior wall of the gastric angle. The SMT was very soft with positive cushion sign. Endoscopic ultrasonography and contrast-enhanced computed tomography revealed that the SMT was a cystic tumor with solid component. Laparoscopic and endoscopic cooperative surgery were performed to remove the tumor. Histopathological analysis revealed that the tumor was a GIST with cystic formation. To the best of our knowledge, this the first documented case of a cushion sign-positive stomach GIST with cystic formation, which had mainly developed inside the stomach. This case suggests that we should keep in mind the possibility of cystic formation of GIST when the tumor has a solid component, even if it appears as a cushion sign-positive SMT.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Joensuu H, Hohenberger P and Corless CL: Gastrointestinal stromal tumour. Lancet. 382:973–983. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Nowain A, Bhakta H, Pais S, Kanel G and Verma S: Gastrointestinal stromal tumors: Clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol. 20:818–824. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Nishida T, Goto O, Raut CP and Yahagi N: Diagnostic and treatment strategy for small gastrointestinal stromal tumors. Cancer. 122:3110–3118. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Joensuu H: Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 39:1411–1419. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, et al: Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol. 33:459–465. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Miettinen M and Lasota J: Gastrointestinal stromal tumors: Pathology and prognosis at different sites. Semin Diagn Pathol. 23:70–83. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Joensuu H, Vehtari A, Riihimäki J, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Cirilli C, Braconi C, et al: Risk of recurrence of gastrointestinal stromal tumour after surgery: An analysis of pooled population-based cohorts. Lancet Oncol. 13:265–274. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Park J, Rubinas TC, Fordham LA and Phillips JD: Multifocal gastrointestinal stromal tumor (GIST) of the stomach in an 11-year-old girl. Pediatr Radiol. 36:1212–1214. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Osada T, Nagahara A, Kodani T, Namihisa A, Kawabe M, Yoshizawa T, Ohkusa T and Watanabe S: Gastrointestinal stromal tumor of the stomach with a giant abscess penetrating the gastric lumen. World J Gastroenterol. 13:2385–2387. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Cruz RJ Jr, Vincenzi R, Ketzer BM, Cecilio AL and Cepeda LA: Spontaneous intratumoral bleeding and rupture of giant gastric stromal tumor (> 30 cm) in a young patient. World J Surg Oncol. 6:762008. View Article : Google Scholar : PubMed/NCBI

11 

Yu CC, Wu CC, Hwang JI, Wang J and Chang CS: Thick calcification from a GIST of the stomach penetrating into pericolic soft tissue-report of a case. World J Surg Oncol. 9:452011. View Article : Google Scholar : PubMed/NCBI

12 

Notani H, Kawamura T, Sato T, Hoshino A, Sato Y and Nakajima A: A case of a giant gastrointestinal stromal tumor of the stomach with extramural growth. Gan To Kagaku Ryoho. 40:2179–2181. 2013.(In Japanese). PubMed/NCBI

13 

Zhu CC, Liu Y and Zhao G: Exophytic gastrointestinal stromal tumor with cystic changes: A case report. Oncol Lett. 7:1427–1429. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Okano H, Tochio T, Suga D, Kumazawa H, Isono Y, Tanaka H, Matsusaki S, Sase T, Saito T, Mukai K, et al: A case of a stomach gastrointestinal stromal tumor with extremely predominant cystic formation. Clin J Gastroenterol. 8:197–201. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Hamza AM, Ayyash EH, Alzafiri R, Francis I and Asfar S: Gastrointestinal stromal tumour masquerading as a cyst in the lesser sac. BMJ Case Rep. 2016:bcr20162154792016. View Article : Google Scholar : PubMed/NCBI

16 

Sun KK, Xu S, Chen J, Liu G, Shen X and Wu X: Atypical presentation of a gastric stromal tumor masquerading as a giant intraabdominal cyst: A case report. Oncol Lett. 12:3018–3020. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Levy AD, Remotti HE, Thompson WM, Sobin LH and Miettinen M: Gastrointestinal stromal tumors: Radiologic features with pathologic correlation. Radiographics. 23:283–304, 456, quiz 532. 2003. View Article : Google Scholar : PubMed/NCBI

18 

de Beer RA and Shinya H: Colonic lipomas. An endoscopic analysis. Gastrointest Endosc. 22:90–91. 1975. View Article : Google Scholar

19 

Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH and Lasota J: Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: A clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol. 25:1121–1133. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Andea AA and Klimstra DS: Adenocarcinoma arising in a tailgut cyst with prominent meningothelial proliferation and thyroid tissue: Case report and review of the literature. Virchows Arch. 446:316–321. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Nishida T, Hirota S, Yanagisawa A, Sugino Y, Minami M, Yamamura Y, Otani Y, Shimada Y, Takahashi F and Kubota T; GIST Guideline Subcommittee: Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version. Int J Clin Oncol. 13:416–430. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Matsuda T, Nunobe S, Kosuga T, Kawahira H, Inaki N, Kitashiro S, Abe N, Miyashiro I, Nagao S, Nishizaki M, et al: Society for the Study of Laparoscopy and Endoscopy Cooperative Surgery: Laparoscopic and luminal endoscopic cooperative surgery can be a standard treatment for submucosal tumors of the stomach: A retrospective multicenter study. Endoscopy. 49:476–483. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, et al: One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial. JAMA. 307:1265–1272. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schütte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, et al: One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: A randomized trial. JAMA. 307:1265–1272. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Frolov A, Chahwan S, Ochs M, Arnoletti JP, Pan ZZ, Favorova O, Fletcher J, von Mehren M, Eisenberg B and Godwin AK: Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors. Mol Cancer Ther. 2:699–709. 2003.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Okagawa Y, Sumiyoshi T, Ihara H, Oiwa S, Tokuchi K, Yoshida M, Fujii R, Minagawa T, Morita K, Hirayama M, Hirayama M, et al: Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report. Mol Clin Oncol 9: 168-172, 2018.
APA
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M. ... Okushiba, S. (2018). Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report. Molecular and Clinical Oncology, 9, 168-172. https://doi.org/10.3892/mco.2018.1639
MLA
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M., Fujii, R., Minagawa, T., Morita, K., Hirayama, M., Kondo, H., Oyamada, Y., Kawarada, Y., Kitashiro, S., Okushiba, S."Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report". Molecular and Clinical Oncology 9.2 (2018): 168-172.
Chicago
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M., Fujii, R., Minagawa, T., Morita, K., Hirayama, M., Kondo, H., Oyamada, Y., Kawarada, Y., Kitashiro, S., Okushiba, S."Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report". Molecular and Clinical Oncology 9, no. 2 (2018): 168-172. https://doi.org/10.3892/mco.2018.1639
Copy and paste a formatted citation
x
Spandidos Publications style
Okagawa Y, Sumiyoshi T, Ihara H, Oiwa S, Tokuchi K, Yoshida M, Fujii R, Minagawa T, Morita K, Hirayama M, Hirayama M, et al: Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report. Mol Clin Oncol 9: 168-172, 2018.
APA
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M. ... Okushiba, S. (2018). Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report. Molecular and Clinical Oncology, 9, 168-172. https://doi.org/10.3892/mco.2018.1639
MLA
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M., Fujii, R., Minagawa, T., Morita, K., Hirayama, M., Kondo, H., Oyamada, Y., Kawarada, Y., Kitashiro, S., Okushiba, S."Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report". Molecular and Clinical Oncology 9.2 (2018): 168-172.
Chicago
Okagawa, Y., Sumiyoshi, T., Ihara, H., Oiwa, S., Tokuchi, K., Yoshida, M., Fujii, R., Minagawa, T., Morita, K., Hirayama, M., Kondo, H., Oyamada, Y., Kawarada, Y., Kitashiro, S., Okushiba, S."Atypical presentation of a cushion sign-positive stomach gastrointestinal stromal tumor with cystic formation: A case report". Molecular and Clinical Oncology 9, no. 2 (2018): 168-172. https://doi.org/10.3892/mco.2018.1639
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team