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Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis

  • Authors:
    • Pei Gao
    • Liang Gong
    • Xuefeng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Otolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 155-162
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    Published online on: June 5, 2018
       https://doi.org/10.3892/mco.2018.1645
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Abstract

Head and neck squamous cell carcinoma (SCC) ranks 6th among the most frequently diagnosed carcinomas globally. Laryngeal carcinoma is quite common, and 95% of the cases are SCCs. Since the introduction of larynx-preserving surgery, induction chemotherapy (IC) has played a substantial role. The aim of IC is to shrink or downstage primary laryngeal carcinomas, increasing the chances of complete surgical removal, particularly in cases with advanced but potentially resectable lesions. The aim of the present study was to investigate the value of IC in patients with resectable laryngeal cancer. A meta-analysis was performed of randomized controlled trials (1985-2017) investigating the effect of IC on survival, disease control, larynx-preserving surgery and disease-free survival. Engauge-Digitizer software was used to construct Kaplan-Meier curves and RevMan software was used for the analysis of the data. A total of 12 trials (4,320 patients) were included. There was no significant difference in local recurrence or locoregional control between patients receiving and those not receiving IC (P>0.05). However, the experimental group (IC) exhibited a lower propensity for distant metastasis by 11.7% (95% confidence interval: 10.3‑13.3%, P=0.02) compared with the control group (no IC). Among patients with laryngeal cancer, larynx preservation was possible in those who responded well to IC, without a significant decrease in survival compared with radical surgery (P<0.05). Taking into consideration these findings, IC confers an advantage in terms of lowering the risk of distant metastasis in patients with resectable laryngeal carcinoma, and enables laryngeal preservation in responders. Moreover, IC increases the overall survival rate in patients with locally advanced but resectable LC.
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Copy and paste a formatted citation
Spandidos Publications style
Gao P, Gong L and Wang X: Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis. Mol Clin Oncol 9: 155-162, 2018.
APA
Gao, P., Gong, L., & Wang, X. (2018). Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis. Molecular and Clinical Oncology, 9, 155-162. https://doi.org/10.3892/mco.2018.1645
MLA
Gao, P., Gong, L., Wang, X."Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis". Molecular and Clinical Oncology 9.2 (2018): 155-162.
Chicago
Gao, P., Gong, L., Wang, X."Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis". Molecular and Clinical Oncology 9, no. 2 (2018): 155-162. https://doi.org/10.3892/mco.2018.1645
Copy and paste a formatted citation
x
Spandidos Publications style
Gao P, Gong L and Wang X: Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis. Mol Clin Oncol 9: 155-162, 2018.
APA
Gao, P., Gong, L., & Wang, X. (2018). Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis. Molecular and Clinical Oncology, 9, 155-162. https://doi.org/10.3892/mco.2018.1645
MLA
Gao, P., Gong, L., Wang, X."Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis". Molecular and Clinical Oncology 9.2 (2018): 155-162.
Chicago
Gao, P., Gong, L., Wang, X."Induction chemotherapy in patients with resectable laryngeal cancer: A meta-analysis". Molecular and Clinical Oncology 9, no. 2 (2018): 155-162. https://doi.org/10.3892/mco.2018.1645
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