Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma

Nakamura,Kohei; Nakayama,Kentaro; Tatsumi,Nagisa; Minamoto,Toshiko; Ishibashi,Tomoka; Ohnishi,Kaori; Yamashita,Hitomi; Ono,Ruriko; Sasamori,Hiroki; Razia,Sultana; Kamrunnahar,Shanta; Ishikawa,Masako; Kyo,Satoru

doi:10.3892/mco.2018.1646

August-2018 Volume 9 Issue 2

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August-2018 Volume 9 Issue 2

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Article Open Access

Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma

Authors:
- Kohei Nakamura
- Kentaro Nakayama
- Nagisa Tatsumi
- Toshiko Minamoto
- Tomoka Ishibashi
- Kaori Ohnishi
- Hitomi Yamashita
- Ruriko Ono
- Hiroki Sasamori
- Sultana Razia
- Shanta Kamrunnahar
- Masako Ishikawa
- Satoru Kyo
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 690‑8504, Japan

Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 138-144
|
Published online on: June 5, 2018

https://doi.org/10.3892/mco.2018.1646
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Abstract

The aim of the present study was to assess the prognostic significance of the pre‑treatment neutrophil‑to‑lymphocyte ratio (NLR), the platelet‑to‑lymphocyte ratio (PLR) and other clinicopathological characteristics in patients with non‑surgically treated uterine cervical carcinoma. The correlations of clinicopathological characteristics with overall and progression‑free survival were determined in 98 Japanese patients who received non‑surgical treatment for uterine cervical carcinoma between January 1997 and July 2013. Survival rates were calculated using the Kaplan‑Meier method and potential prognostic indicators were assessed using a Cox proportional hazards model. A total of 68 patients (69.4%) had a high pre‑treatment NLR (≥3.5) and 34 patients (34.7%) had a high pre‑treatment PLR (≥212). Both NLR and PLR were found to be positively correlated with pre‑treatment platelet counts. Multivariate analysis identified NLR and carcinoembryonic antigen level, but not PLR, as independent predictors of overall and progression‑free survival. In conclusion, the present study identified two prognostic indicators for uterine cervical carcinoma, both of which can be easily and cost‑effectively monitored via blood testing.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prognostic significance of pre‑treatment neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios in non‑surgically treated uterine cervical carcinoma

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Abstract

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