Double cancer comprising malignant pleural mesothelioma and squamous cell carcinoma of the lung treated with radiotherapy: A case report

Negi,Yoshiki; Kuribayashi,Kozo; Doi,Hiroshi; Funaguchi,Norihiko; Koda,Yuichi; Fujimoto,Eriko; Mikami,Koji; Minami,Toshiyuki; Yokoi,Takashi; Kijima,Takashi

doi:10.3892/mco.2018.1650

August-2018 Volume 9 Issue 2

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August-2018 Volume 9 Issue 2

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Case Report

Double cancer comprising malignant pleural mesothelioma and squamous cell carcinoma of the lung treated with radiotherapy: A case report

Authors:
- Yoshiki Negi
- Kozo Kuribayashi
- Hiroshi Doi
- Norihiko Funaguchi
- Yuichi Koda
- Eriko Fujimoto
- Koji Mikami
- Toshiyuki Minami
- Takashi Yokoi
- Takashi Kijima
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Radiology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Respiratory Medicine, Murakami Memorial Hospital, Asahi University, Mizuho, Gifu 500‑8523, Japan
Pages: 181-186
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Published online on: June 11, 2018

https://doi.org/10.3892/mco.2018.1650
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Abstract

Pleurectomy/decortication (P/D) is the surgical treatment of choice for early malignant mesothelioma, but it remains unclear whether radiotherapy along with P/D should be used as multimodal treatment for this disease. We herein present the case of a 76‑year‑old man with a history of asbestos exposure who was diagnosed with left‑sided malignant pleural mesothelioma in February 2010. The patient underwent chemotherapy with a combination of cisplatin and pemetrexed and achieved stable disease, after which time he was kept under observation. A positron emission tomography/computed tomography scan performed in February 2011 revealed nodular shadows with fluorodeoxyglucose uptake in S3 of the left lung; using bronchoscopy, the patient was diagnosed with stage IIB (cT3N0M0) primary squamous cell carcinoma. Chemoradiotherapy with vinorelbine and 60 Gy/20 fr radiotherapy was performed, and a partial response was obtained, suggesting that the radiotherapy used to treat the carcinoma of the lung may have also helped control the disease activity of the pre‑existing mesothelioma. The present case indicates the value of radiotherapy in the treatment of malignant mesothelioma. The aim of the present study was to examine the possibility of new multimodal treatments for mesothelioma, along with a discussion of the relevant literature.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Double cancer comprising malignant pleural mesothelioma and squamous cell carcinoma of the lung treated with radiotherapy: A case report

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