Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report

  • Authors:
    • Jieyun Xia
    • Haiying Sun
    • Zhiling Yan
    • Feng Zhu
    • Kai Zhao
    • Kailin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 297-301
    |
    Published online on: June 25, 2018
       https://doi.org/10.3892/mco.2018.1661
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Philadelphia chromosome (Ph)‑positive acute lymphoblastic leukemia (ALL) complicated by bone marrow necrosis (BMN) and acute renal insufficiency (ARI) is rare in clinical practice. The aim of the present study was to summarize the clinical characteristics and treatment methods of a case of Ph+ ALL complicated by BMN and ARI. A 23‑year‑old male patient presented with pyrexia and a 2‑month history of bone pain, and was diagnosed with Ph+ ALL complicated with BMN and ARI on peripheral blood tests, blood biochemistry tests, BM smear and fluorescence in situ hybridization. The patient underwent repeated hemodialysis, imatinib combination and maintenance chemotherapy, followed by allogeneic hematopoietic stem‑cell transplantation. Some of the clinical signs and symptoms were alleviated, whereas others disappeared, and renal function was restored to normal. BM aspiration confirmed absence of necrosis and null lymphoblasts. Therefore, timely accurate diagnosis and effective treatment are crucial for patients with Ph+ ALL exhibiting potentially fatal complications.
View Figures

Figure 1

Figure 2

View References

1 

Davi F, Gocke C, Smith S and Sklar J: Lymphocytic progenitor cell origin and clonal evolution of human B-lineage acute lymphoblastic leukemia. Blood. 88:609–621. 1996.PubMed/NCBI

2 

Montemayor-Montoya JL, De León-Cantú RE, Gómez-Almaguer D and Herrera-Garza JL: 3 cases of bone marrow necrosis in acute leukemia. Rev Invest Clin. 49:295–298. 1997.(In Spanish). PubMed/NCBI

3 

Canet E, Zafrani L, Lambert J, Thieblemont C, Galicier L, Schnell D, Raffoux E, Lengline E, Chevret S, Darmon M and Azoulay E: Acute kidney injury in patients with newly diagnosed high-grade hematological malignancies: Impact on remission and survival. PLoS One. 8:e558702013. View Article : Google Scholar : PubMed/NCBI

4 

Moorman AV, Harrison CJ, Buck GA, Richards SM, Secker-Walker LM, Martineau M, Vance GH, Cherry AM, Higgins RR, Fielding AK, et al: Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial. Blood. 109:3189–3197. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Bernard C, Sick H, Boilletot A and Oberling F: Bone marrow necrosis. acute microcirculation failure in myelomonocytic leukemia. Arch Intern Med. 138:1567–1569. 1978. View Article : Google Scholar : PubMed/NCBI

6 

Paydas S, Ergin M, Baslamisli F, Yavuz S, Zorludemir S, Sahin B and Bolat FA: Bone marrow necrosis: Clinicopathologic analysis of 20 cases and review of the literature. Am J Hematol. 70:300–305. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Lackner H, Strenger V, Sovinz P, Beham-Schmid C, Pilhatsch A, Benesch M, Schwinger W, Ulreich R, Schmidt S and Urban C: Bone marrow necrosis in a girl with Hodgkin's disease. Support Care Cancer. 20:2231–2234. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Moritake H, Obara M, Sameshima N, Asada Y, Komatsu H, Hyakuna N, Sugita K, Ishida Y, Kato M, Tanizawa A, et al: Analysis of the molecular mechanism underlying bone marrow necrosis with acute lymphoblastic leukemia. Int J Hematol. 102:349–356. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Seki Y, Koike T, Yano M, Aoki S, Hiratsuka M, Fuse I and Aizawa Y: Bone marrow necrosis with dyspnea in a patient with malignant lymphoma and plasma levels of thrombomodulin, tumor necrosis factor-alpha, and D-dimer. Am J Hematol. 70:250–253. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Kellum JA, Lameire N, Aspelin P, Barsoum RS, Burdmann EA, Goldstein SL, Herzog CA, Joannidis M, Kribben A, Levey AS, et al: Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2:1–138. 2012.

11 

Abu-Alfa AK and Younes A: Tumor lysis syndrome and acute kidney injury: Evaluation, prevention, and management. Am J Kidney Dis. 55 5 Suppl 3:S1–S13; quiz S14-S19. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Soares M, Salluh JI, Carvalho MS, Darmon M, Rocco JR and Spector N: Prognosis of critically ill patients with cancer and acute renal dysfunction. J Clin Oncol. 24:4003–4010. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Canet E, Vincent F, Darmon M and Soares M: Acute kidney injury in hematological patients. Curr Opin Crit Care. 21:549–558. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Cairo MS and Bishop M: Tumour lysis syndrome: New therapeutic strategies and classification. Br J Haematol. 127:3–11. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Stapleton FB, Strother DR, Roy S III, Wyatt RJ, McKay CP and Murphy SB: Acute renal failure at onset of therapy for advanced stage Burkitt lymphoma and B cell acute lymphoblastic lymphoma. Pediatrics. 82:863–869. 1988.PubMed/NCBI

16 

Annemans L, Moeremans K, Lamotte M, Conde Garcia J, van den Berg H, Myint H, Pieters R and Uyttebroeck A: Incidence, medical resource utilisation and costs of hyperuricemia and tumour lysis syndrome in patients with acute leukaemia and non-Hodgkin's lymphoma in four European countries. Leuk Lymphoma. 44:77–83. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Coiffier B, Altman A, Pui CH, Younes A and Cairo MS: Guidelines for the management of pediatric and adult tumor lysis syndrome: An evidence-based review. J Clin Oncol. 26:2767–2778. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Oiwa K, Morita M, Kishi S, Okura M, Tasaki T, Matsuda Y, Tai K, Hosono N, Ueda T and Yamauchi T: High risk of tumor lysis syndrome in symptomatic patients with multiple myeloma with renal dysfunction treated with bortezomib. Anticancer Res. 36:6655–6662. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kjellstrand CM, Cambell DC II, von Hartitzsch B and Buselmeier TJ: Hyperuricemic acute renal failure. Arch Intern Med. 133:349–359. 1974. View Article : Google Scholar : PubMed/NCBI

20 

Tsokos GC, Balow JE, Spiegel RJ and Magrath IT: Renal and metabolic complications of undifferentiated and lymphoblastic lymphomas. Medicine (Baltimore). 60:218–229. 1981. View Article : Google Scholar : PubMed/NCBI

21 

Shimada M, Johnson RJ, May WS Jr, Lingegowda V, Sood P, Nakagawa T, Van QC, Dass B and Ejaz AA: A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant. 24:2960–2964. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Prasada H: Sevelamer hydrochloride for tumor lysis syndrome-related hyperphosphatemia. Indian Pediatr. 52:613–615. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Uprety D, Peterson A and Shah BK: Renal failure secondary to leukemic infiltration of kidneys in CLL-a case report and review of literature. Ann Hematol. 92:271–273. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Spapen J, Fostier K, De Raeve H, Janssens P and Spapen H: An unexpected complication of chronic myelomonocytic leukemia: Severe renal failure due to malignant tubulo-interstitial cell infiltration. Int J Nephrol Renovasc Dis. 9:1–4. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Lim SN, Joo YD, Lee KH, Kim DY, Lee JH, Lee JH, Chi HS, Yun SC, Lee WS, Lee SM, et al: Long-term follow-up of imatinib plus combination chemotherapy in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. Am J Hematol. 90:1013–1020. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xia J, Sun H, Yan Z, Zhu F, Zhao K and Xu K: Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Mol Clin Oncol 9: 297-301, 2018.
APA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., & Xu, K. (2018). Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Molecular and Clinical Oncology, 9, 297-301. https://doi.org/10.3892/mco.2018.1661
MLA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9.3 (2018): 297-301.
Chicago
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9, no. 3 (2018): 297-301. https://doi.org/10.3892/mco.2018.1661
Copy and paste a formatted citation
x
Spandidos Publications style
Xia J, Sun H, Yan Z, Zhu F, Zhao K and Xu K: Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Mol Clin Oncol 9: 297-301, 2018.
APA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., & Xu, K. (2018). Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. Molecular and Clinical Oncology, 9, 297-301. https://doi.org/10.3892/mco.2018.1661
MLA
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9.3 (2018): 297-301.
Chicago
Xia, J., Sun, H., Yan, Z., Zhu, F., Zhao, K., Xu, K."Successful treatment of a patient with Philadelphia chromosome‑positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report". Molecular and Clinical Oncology 9, no. 3 (2018): 297-301. https://doi.org/10.3892/mco.2018.1661
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team